InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK
...inflammatoryinterleukin1receptor(IL-1R)familyaredependentonthepresenceofMyD88forefficientsignaltransduction.ThebipartitenatureofMyD88(N-terminaldeathdomain[DD]andCOOH-terminalToll/IL-1receptor[TIR]domain)allowsittolinktheTIRdomainofIL-1R/TLRwiththeDDoftheSer/ThrkinasetermedIL-1R–associatedkinase(I...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK
...inflammatoryinterleukin1receptor(IL-1R)familyaredependentonthepresenceofMyD88forefficientsignaltransduction.ThebipartitenatureofMyD88(N-terminaldeathdomain[DD]andCOOH-terminalToll/IL-1receptor[TIR]domain)allowsittolinktheTIRdomainofIL-1R/TLRwiththeDDoftheSer/ThrkinasetermedIL-1R–associatedkinase(I...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第2期MyD88-dependentinductionofallergicTh2responsestointranasalantigen
...atology,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,USA.AbstractMyD88isacommonToll-likereceptor(TLR)adaptormoleculefoundtobeessentialforinductionofadaptiveTh1immunity.Conversely,innatecontrolofadaptiveTh2immunityhasbeenshowntooccurinaMyD88-independentmanner.Inthisstudy,weshowthatMyD88isaness...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第2期WoundHealingIsImpairedinMyD-DeficientMice
...(VEGF).WeshowinthisstudythatthisswitchcriticallyrequiressignalingthroughMyD88,IRAK4,andTRAF6.MacrophagesfrommicelackingMyD88(MyD88C/C)orIRAK4(IRAK4C/C)lackedresponsivenesstoTLRagonistsanddidnotrespondtoA2ARagonistsbyexpressingVEGF.SuppressionofTRAF6expressionwithsiRNAinRAW264.7macrophagesalsoblocked...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第12期InnateimmunitymediatedbyTLR9modulatespathogenicityinananimalmodelofmultiplesclerosis
...unity,westudiedtheroleofdifferentTLRsaswellastheircommonsignalingadaptorMyD88inthedevelopmentofEAE.WefoundthatMyD88–/–micewerecompletelyEAEresistant.Surprisingly,thisprotectionispartlyduetoengagementoftheCpGreceptorTLR9.RestrictingtheMyD88orTLR9mutationtohostradio-resistantcells,includingthecell...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期MyD88-dependentIL-1receptorsignalingisessentialforgoutyinflammationstimulatedbymonosodiumuratecrystals
...R(TIR)signaltransductionadaptormyeloiddifferentiationprimaryresponseprotein88(MyD88)isrequiredforacutegoutyinflammation.Incontrast,otherTIRadaptormolecules,TIRAP/Mal,TRIF,andTRAM,arenotrequiredforthisprocess.TheMyD88-dependentTLR1,-2,-4,-6,-7,-9,and-11andIL-18receptor(IL-18R)arenotessentialforMSU-in...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期AcuteBrainInjuryTriggersMyD-DependentTLR/-IndependentInflammatoryResponses
...swellasinneutrophilaccumulationinmicelackingthecommonTLRsignalingadaptorMyD88comparedwithwild-typemice.Notably,attenuationoftheimmuneresponsewasparalleledbyareductioninlesionsize.Neutrophildepletionofwild-typemiceandtransplantationofMyD88-deficientbonemarrowintolethallyirradiatedwild-typerecipientsh...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第7期TLR9/MyD88signalingisrequiredforclassswitchingtopathogenicIgG2aand2bautoantibodiesinSLE
...genicsubclassesrequirestheinnateimmunereceptorToll-likereceptor(TLR)9andMyD88signaling.Intheirabsence,switchingofautoreactiveBcellstotheIgG2aand2bsubclassesisblocked,resultinginreducedpathologyandmortality.Incontrast,switchingofanti-selfBcellstoIgG1isnotperturbedandgenerationofnonautoreactiveIgG2aan...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期Applicationofβ-LactamaseEnzymeComplementationtotheHigh-ThroughputScreeningofToll-LikeReceptorSignalingInhibitors
...LR4)signalinginhibitors.Wedevelopedastablecellline,HeLa/CL3-4,expressingMyD88/Bla(a)andTLR4/Bla(b),inwhichthetwoβ-lactamasefragmentscomplementwitheachotherbyvirtueofspontaneousMyD88-TLR4bindingviatheirToll/IL-1R(TIR)domains.InhibitionoftheMyD88-TLR4bindingleadstothedisruptionoftheenzymecompleme...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期PROGEN公司第二期肝癌试验结果即将发表
...号:PGL,NASDAQ代号:PGLA)2007年4月16日宣布其抗癌药物PI-88适用于手术切除后肝癌患者第二期临床试验总结报告,试验48周的数据显示,PI-88可以有效降低25%的肝癌复发率,且可延长78%肝癌复发时间(27周延长到48周)。PI-88是Progen...
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