pUbiquitinBinding-AssociatedDomainMediatedtheReceptorActivatorofNuclearFactor-BLigand-InducedOsteoclastFormation
...struction,andirregularboneformation.Recently,mutationsinSQSTM1(alsoknownasp62)havebeendetectedinPDBsufferers,withallmutationsresultingineitherlossoffunctionortruncation/deletionoftheubiquitinbinding-associated(UBA)domain.Wehypothesizedthatmutationinthep62generesultingineitherdeletionorprematuretermi...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期Cu-PTSM:一种用于PET显像的药物
...其相对分子量约为63.546,其放射性同位素包括,60Cu,61Cu,62Cu和64Cu。60Cu和62Cu的半衰期为23.4min和9.8min,而61Cu和64Cu半衰期是204.5min和761.9min,由于上述特征,用64Cu标记PTSM(丙酮醛双N4-2甲基缩氨基硫脲)后适合做细胞和多肽的生物学...
医源资料库;在线期刊;中华医药杂志;2007年第7卷第11期CD44与CD62P在肾脏疾病中的表达及意义
CD44与CD62P在肾脏疾病中的表达及意义免疫学杂志2000年第1期第16卷临床免疫学作者:孙晓明 罗南萍 杨道理单位:孙晓明(济南军区总医院免疫科,山东济南250031);罗南萍(济南军区总医院免疫科,山东济南250031);杨道理...
合作平台;医学论文;临床医学与专科论文;检验医学SinglecellanalysisshowsdecreasingFoxP3andTGF1coexpressingCD4+CD25+regulatoryTcellsduringautoimmunediabetes
...)mouse,amurinemodelfortype1diabetes(T1D).ThesuppressorfunctionofCD4+CD25+CD62LhiTcells,mediatedbyTGF,declinedinanage-dependentmanner.ThislossoffunctioncoincidedwithatemporaldecreaseinthepercentageofFoxP3andTGF1coexpressingTcellswithinpancreaticlymphnodeandisletinfiltratingCD4+CD25+CD62LhiTcells,andw...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期系统性红斑狼疮患者CD62P、CD63表达与SLEDAI相关性分析
...:观察系统性红斑狼疮(SLE)患者外周血血小板膜蛋白CD62P,CD63的表达,并探讨CD62P、CD63与SLE疾病活动指数(SLEDAI)之间的相关性。方法:采用流式细胞术对10例SLE患者外周血CD62P、CD63进行检测分忻,以20例正常人作为对照。同...
合作平台;医学论文;临床医学与专科论文;检验医学DifferentialcontributionsofcentralandeffectormemoryTcellstorecallresponses
...onsetosecondarypathogenchallenge.ThistemporalincreaseinefficacyoccurredinCD62Llo(effectormemory)andCD62Lhi(centralmemory)subpopulations,butwasmostprominentintheCD62Lhisubpopulation.ThesedataindicatethatthecontributionofeffectormemoryandcentralmemoryTcellstotherecallresponsechangessubstantiallyoverti...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第1期RoleofProteinKinaseCandItsAdaptorProteinp62inVoltage-GatedPotassiumChannelModulationinPulmonaryArteries
...nnels.Inthecurrentstudy,weaimedtoelucidatetheroleofPKCanditsadaptorproteinp62inthemodulationofKVchannels.WereportthatthethromboxaneA2analog9,11-dideoxy-11,9-epoxymethano-prostaglandinF2methylacetate(U46619[GenBank])inhibitedKVcurrentsinisolatedmicepulmonaryarterymyocytesandtheKVcurrentcarriedbyhuman...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期粘附分子CD11a、CD11b、CD62L在恶性淋巴增殖性疾病的表达
粘附分子CD11a、CD11b、CD62L在恶性淋巴增殖性疾病的表达中国免疫学杂志2000年第11期第16卷肿瘤免疫学作者:童秀珍 罗绍凯 洪文德 彭爱华单位:中山医科大学附属第一医院血液科,广州510080 关键词:淋巴肉瘤白血病;急性...
合作平台;医学论文;临床医学与专科论文;检验医学AcquisitionoffulleffectorfunctioninvitroparadoxicallyimpairstheinvivoantitumorefficacyofadoptivelytransferredCD8+Tcells
...fullymatureeffectorCD8+Tcells,asindicatedbytheprogressivedownregulationofCD62L,chemokinereceptor7(CCR7),?7integrin,andCD27andtheconcurrentincreaseinthelevelsofCD44,CD69,CD25,andgranzyme-B(Figure1A).TheacquisitionofaneffectorphenotypewasassociatedwithanincreaseincytolyticactivityandIFN-releasebutadec...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期Lineagerelationships,homeostasis,andrecallcapacitiesofcentral–andeffector–memoryCD8Tcellsinvivo
...horttimeintheabsenceofantigenand,althoughafractionofthemwereabletoexpressCD62L,theywereunabletomountaproliferativeresponseuponsecondarychallengeinthismodel.Abbreviationsused:TCM,central–memoryTcells;TEM,effector–memoryTcells.DuetothepersistenceofmemoryTandBlymphocytesandlong-livedplasmacells,the...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期