ConversionofCD4+CD25–cellsintoCD4+CD25+regulatoryTcellsinvivorequiresB7costimulation,butnotthethymus
...ology,UniversityofLouisvilleHealthScienceCenter,Louisville,KY40202TheCD4+CD25+regulatoryTcellsplayacriticalroleincontrollingautoimmunity,butlittleisknownabouttheirdevelopmentandmaintenance.Inthisstudy,weinvestigatedwhetherCD4+CD25–cellscanconverttoCD4+CD25+regulatoryTcellsinvivoundernaturalconditi...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第1期VitaminDstatus:effectsonparathyroidhormoneand1,25-dihydroxyvitaminDinpostmenopausalwomen
...0,Australia.E-mail:allan.need{at}imvs.sa.gov.au.ABSTRACTBackground:Lowserum25-hydroxyvitaminD[25(OH)D]concentrationsarecommonlyfoundintheelderlyandareassociatedwithhipfracture.TreatmentwithvitaminDandcalciumcanreducetheriskoffracture.Therelationbetweentheriseinparathyroidhormone(PTH)withageandthedec...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第6期CD4+CD25+RegulatoryTLymphocytesinMalignantPleuralEffusion
...angxi,People‘sRepublicofChinaABSTRACTBackground:ActivesuppressionbyCD4+CD25+regulatoryTlymphocytesplaysanimportantroleinthedownregulationofT-cellresponsestoforeignandself-antigens.Objective:ToanalyzewhethertheCD4+CD25+regulatoryTlymphocytesexistandfunctionnormallyinmalignantpleuraleffusion.Methods...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第12期IndependentMechanisticInhibitionofCdc25PhosphatasesbyaNaturalProductCaulibugulone
...ermis.WenowreportthatthecaulibugulonesareselectiveinvitroinhibitorsoftheCdc25familyofcellcycle-controllingproteinphosphatasescomparedwitheitherhumanvacciniaH1-relatedphosphatase(VHR)ortyrosinephosphatase1B(PTP1B).TheinvitroinhibitionofCdc25BbycaulibuguloneAwasirreversibleandattenuatedbyreducingagent...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期OV系列色谱柱资料(1)
OV-225通用型毛细管色谱柱OV-225柱是由25%氰丙基,25%苯基的聚硅氧烷交联柱。Tmax≤265℃,本产品类似于:DB-225,SP-2300,HP-225,CPSIL43CB,BP-225,Rxt-225等国外柱子,广泛应用于多环苯烃、硝基苯烃、酚、醇、多氯联苯、吡啶联苯胺、酯、氯代...
药品天地;专业药学;实验技术;色谱技术;仪器介绍与操作VitaminD
...minDitselfisaprohormonethatismetabolicallyconvertedtotheactivemetabolite,1,25-dihydroxyvitaminD[1,25(OH)2D].ThisvitaminDhormoneactivatesitscellularreceptor(vitaminDreceptororVDR),whichaltersthetranscriptionratesoftargetgenesresponsibleforthebiologicalresponses.Thisreviewfocusesonseveralrecentdevelop...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第7期Theeffectsofseasonalvariationof25-hydroxyvitaminDandfatmassonadiagnosisofvitaminDsufficiency
...inicalpractice.Objectives:Weaimedtodeterminetheeffectsofseasonalvariationof25-hydroxyvitaminD[25(OH)D]onapreviouslyselectedminimumconcentrationforvitaminDsufficiency(50nmol/L)andtodeterminewhetherfatmassmodifiestheseeffects.Design:Across-sectionalstudyevaluated1606healthypostmenopausalwomenand378old...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第4期Virus-induceddysfunctionofCD4+CD25+TcellsinpatientswithHTLV-I–associatedneuroimmunologicaldisease
...teofNeurologicalDisordersandStroke,NIH,Bethesda,Maryland,USA.AbstractCD4+CD25+Tregsareimportantinthemaintenanceofimmunologicalselftoleranceandinthepreventionofautoimmunediseases.AstheCD4+CD25+TcellpopulationinpatientswithhumanTcelllymphotropicvirustypeI–associated(HTLV-I–associated)myelopathy/tr...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期Serum25-hydroxyvitaminDconcentrationsandrelateddietaryfactorsinperi-andpostmenopausalJapanesewomen
...ritioninAsianpopulationshavebeenconducted.Objective:Theobjectivewastoassess25-hydroxyvitaminD[25(OH)D]concentrationsinhealthyelderlyJapanesewomenduringthewinterandtodeterminewhether25(OH)Dconcentrationsareassociatedwithlifestyle.Design:Weinvestigated151womenaged66.5±6.7y(Results:Themean(±S...
医源资料库;在线期刊;美国临床营养学杂志;2000年71卷第5期NFATc2andNFATc3transcriptionfactorsplayacrucialroleinsuppressionofCD4+TlymphocytesbyCD4+CD25+regulatoryTcells
...mphadenopathy,splenomegaly,andautoaggressivephenomena.ThepopulationofCD4+CD25+TcellsfromDKOmicelacksregulatorycapacity,exceptasmallsubpopulationthathighlyexpressesglucocorticoid-inducedtumornecrosisfactorreceptorfamily–relatedgene(GITR)andCD25.However,neitherwild-typenorDKOCD4+CD25+regulatoryTcell...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第2期