Enhancementofvaccine-mediatedantitumorimmunityincancerpatientsafterdepletionofregulatoryTcells
...hCarolina,USA.AbstractInthisstudy,weinvestigatedwhethereliminationofCD4+/CD25+TregsusingtherecombinantIL-2diphtheriatoxinconjugateDAB389IL-2(alsoknownasdenileukindiftitoxandONTAK)iscapableofenhancingtheimmunostimulatoryefficacyoftumorRNA-transfectedDCvaccines.WeshowthatDAB389IL-2iscapableofselective...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期OverviewofgeneralphysiologicfeaturesandfunctionsofvitaminD
...radiationof7-dehydrocholesterol.Itisbiologicallyinertandmustbemetabolizedto25-hydroxyvitaminD3intheliverandthento1,25-dihydroxyvitaminD3inthekidneybeforefunction.ThehormonalformofvitaminD3,ie,1,25-dihydroxyvitaminD3,actsthroughanuclearreceptortocarryoutitsmanyfunctions,includingcalciumabsorption,pho...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第6期Serum25-hydroxyvitaminDinaWestAfricanpopulationoftuberculosispatientsandunmatchedhealthycontrols
...controlstudywasperformedataDemographicSurveillanceSiteinGuinea-Bissau.Serum25-hydroxyvitaminD3[25(OH)D3]concentrationsweremeasuredin362TBpatientsandin494controls.Results:HypovitaminosisD[25(OH)D375nmol/L]wasmorecommoninTBpatients,butVDD[25(OH)D350nmol/L]wasmorecommonandmoresevereincontrols.Weobserve...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第5期VitaminDrequirementsduringlactation:high-dosematernalsupplementationastherapytopreventhypovitaminosisDforboththemotherandthenursinginfant
...oBWHollis,MedicalUniversityofSouthCarolina,173AshleyAvenue,Charleston,SC29425.E-mail:hollisb{at}musc.edu.ABSTRACTScientificdatapertainingtovitaminDsupplementationduringlactationarescarce.ThedailyrecommendedintakeforvitaminDduringlactationhasbeenarbitrarilysetat400IU/d(10µg/d).Thisrecommendation...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第6期VitaminDrequirementsduringpregnancy
...egnancy,toprovidethecalciumneededforfetalbonemineralaccretion.Approximately25-30gofcalciumaretransferredtothefetalskeletonbytheendofpregnancy,mostofwhichistransferredduringthelasttrimester.Ithasbeenestimatedthatthefetusaccumulatesupto250mg/dcalciumduringthethirdtrimester(1).The3possiblecalciumsource...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第6期VitaminDstatusinadolescentsandyoungadultswithHIVinfection
...minewhetherHIVinfectionwasassociatedwithvitaminDinsufficiency.Design:Plasma25-hydroxyvitaminD[25(OH)D]concentrationsandvitaminDintakeweremeasuredinacross-sectionalstudyofmembersoftheReachingforExcellenceinAdolescentHealth(REACH)cohort.Results:Thesubjectswereaged1423y;74%werefemale,and72%werebl...
医源资料库;在线期刊;美国临床营养学杂志;2006年83卷第5期Diminishedanderraticabsorptionofergocalciferolinadultcysticfibrosispatients
...jective:Absorptionoforalergocalciferol(vitaminD2)andtheconsequentresponseof25-hydroxyvitaminDin10adultswithCFandexocrinepancreaticinsufficiencywascomparedwiththatof10healthycontrolsubjects.Design:Inthispharmacokineticstudy,CFpatientsandcontrolsubjectswerepair-matchedonage,sex,andrace.Eachsubjectcons...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第3期IFN-productionbyalloantigen-reactiveregulatoryTcellsisimportantfortheirregulatoryfunctioninvivo
...activeTregcells,pretreatedmicewererechallengedwithdonoralloantigeninvivo.CD25+CD4+Tcells,butnotCD25–CD4+Tcells,showedafivefoldincreaseinIFN-mRNAexpressionwithin24hofreencounteringalloantigeninvivo.Thisexpressionkineticwashighlyantigen-specificandwasoffunctionalsignificance.NeutralizingIFN-atthetim...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第12期Infectedsite-restrictedFoxp3+naturalregulatoryTcellsarespecificformicrobialantigens
...ecognitionisnecessaryfortheirfunctionandsurvival.RESULTSThemajorityofCD4+CD25hiTcellsfromtheregionalLNofchronicallyinfectedmiceproliferateinresponsetoL.major–infectedDCsWehavepreviouslyshownthatnaturallyoccurringTregcellsaccumulateatdermalsitesofLeishmaniainfectionandproduceIL-10inresponsetoL.majo...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期16.7维生素D的临床应用
...要是由于机体内在原因,维生素D的代谢不能正常进行,25-(OH)D、1,25-(OH)2D等活性代谢物的生成减少。所以,在食物维生素D能满足正常生理需要的情况下,也可以发生维生素D缺乏的症状。并有这种维生素D缺乏病需要使用大...
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