VitaminDdeficiencyandassociatedfactorsinadolescentgirlsinBeijing
...istics,physicalactivity,signsandsymptomsofrickets,andplasmaconcentrationsof25-hydroxyvitaminD,1,25-dihydroxyvitaminD,andcalciumweremeasuredandX-raysofthehandandwristweretaken.Results:TheprevalenceofclinicalvitaminDandcalciumdeficiency(plasma25-hydroxyvitaminD12.5nmol/L,plasmacalcium2.25mmol/L,andmus...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第4期SuperagonisticActionof14-epi-Analogsof1,25-DihydroxyvitaminDExplainedbyVitaminDReceptor-CoactivatorInteraction
...mie,UniversiteitGent,Gent,Belgium(P.D.C.,M.V.)AbstractTwo14-epi-analogsof1,25-dihydroxyvitaminD3[1,25-(OH)2D3],19-nor-14-epi-23-yne-1,25-(OH)2D3(TX522)and19-nor-14,20-bisepi-23-yne-1,25-(OH)2D3(TX527),showenhancedantiproliferative(atleast10-fold)andmarkedlylowercalcemiceffectsbothinvitroandinvivo,co...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期Nonneutralizingantibodiesbindingtothesurfaceglycoproteinoflymphocyticchoriomeningitisvirusreduceearlyvirusspread
...onevirusesisunclear.WedemonstratethatcytotoxicTlymphocyte–deficientTgH(KL25)mice,whicharetransgenicfortheheavychainofthelymphocyticchoriomeningitisvirus(LCMV)–neutralizingmonoclonalantibodyKL25,mountafocusedneutralizingantibodyresponsefollowingLCMVinfection,andthatthisresultsintheemergenceofneut...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期VitaminDinsufficiencyinchildren,adolescents,andyoungadultswithcysticfibrosisdespiteroutineoralsupplementation
...asimilargeographicarea.Design:Growth,dietaryintake,andserumconcentrationsof25-hydroxyvitaminD[25(OH)D],1,25-dihydroxyvitaminD[1,25(OH)2D],andparathyroidhormone(PTH)weremeasuredin101whitesubjectswithCFandareferencegroupof177whitesubjects.Results:ThemediandailyvitaminDsupplementationintheCFgroupwas800...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第6期5.3维生素D
...生素D运到肝脏中,在微粒体中经单氧酶系统作用,将其25位羟基化形成25(OH)D(25-hydroxyvitaminD3)(图5-7),肝外的其他组织也可吸取维生素D及25-(OH)D3,因此组织中维生素D及25(OH)D3及其总量比血浆中多,如果靶组织需要,可将...
医源资料库;医源图书馆;教材类;临床营养学EffectsofvitaminDmetabolitesonintestinalcalciumabsorptionandboneturnoverinelderlywomen
...measurementofmarkersofboneturnoverandcalciummetabolism.Results:Themeanserum25-hydroxyvitaminD[25(OH)D]concentrationatthetimeofthecalciumabsorptiontestwas68±29nmol/L.Gutcalciumabsorptionwascorrelatedwith25(OH)Dbutnot1,25-dihydroxyvitaminD(calcitriol),thefreecalcitriolindex,ordietarycalciumintake...
医源资料库;在线期刊;美国临床营养学杂志;2002年75卷第2期RegulatoryTcellsandIL-10inallergicinflammation
...ellsdescribedtodate.Thefirstisthenaturallyoccurring,thymicallyderivedCD4+CD25+TregcellsthatexpresshighlevelsofthetranscriptionfactorFoxp3,whichisessentialfortheirdevelopmentandfunction(3–6).Theothercategoryistheantigen-specificTregcells,whichcanbeinducedinvitroandinvivounderparticularconditionsofa...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期Bodymassindexhistoryandriskoftype2diabetes:resultsfromtheEuropeanProspectiveInvestigationintoCancerandNutrition(EPIC)PotsdamStudy
...essionmodelswereusedtoestimatetherelativerisk(RR)ofweightchangesbetweenages25and40yandages40and55y.Results:RRestimatesinmenandwomenwereslightlyhigherforeachunitofBMIgainbetweenages25and40y[men:1.25(95%CI:1.21,1.30);women:1.24(1.20,1.27)]thanbetweenages40and55y[men:1.13(1.10,1.16);women:1.11(1.08,1.1...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第2期Highprevalenceoflowdietarycalcium,highphytateconsumption,andvitaminDdeficiencyinhealthysouthIndians
...e:Theobjectivewastodocumentthedietaryhabitsandconcentrationsofserumcalcium,25-hydroxyvitaminD[25(OH)D],andparathyroidhormoneofIndianurbanandruralpopulations.Design:Healthyurban(n=943)andrural(n=205)subjectswerestudiedfortheirdietarypatternandconcentrationsofserumcalcium,phosphorus,alkalinephosphatas...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第4期维生素D的免疫功能及肾脏疾病中的应用
【关键词】维生素D;免疫功能;临床应用 1,25-二羟维生素D [1,25(OH)2D]是一种具有多种生物活性的类固醇激素。它不仅在钙和骨的代谢中发挥重要作用,同时主要通过维生素D受体介导其免疫调节作用。临床上各种原因导致的肾...
医源资料库;在线期刊;中华现代内科学杂志;2010年第7卷第1期