VitaminDrequirements:currentandfuture
...edvaluestopreventseasonalvariationsinparathyroidhormoneconcentrations.Serum25-hydroxyvitaminDconcentrationswereconsideredthebestindicatorofvitaminDadequacy,becausetheproductionof25-hydroxyvitaminDisnotregulated.Normalrangeswereobtainedfromreferencepopulations,butthevaluesvariedwidelywithageandgeogra...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第6期SinglecellanalysisshowsdecreasingFoxP3andTGF1coexpressingCD4+CD25+regulatoryTcellsduringautoimmunediabetes
...ology,UniversityofNorthCarolinaatChapelHill,ChapelHill,NC27599NaturalCD4+CD25+regulatoryT(CD4+CD25+Treg)cellsplayakeyroleintheimmunoregulationofautoimmunity.However,littleisknownabouttheinteractionsbetweenCD4+CD25+TregcellsandautoreactiveTcells.Thisisdue,inpart,tothedifficultyofusingcellsurfacemarke...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期CD127expressioninverselycorrelateswithFoxP3andsuppressivefunctionofhumanCD4+Tregcells
...egulatorsofimmunetolerance.MostTregcellsaredefinedbasedonexpressionofCD4,CD25,andthetranscriptionfactor,FoxP3.However,thesemarkershaveprovenproblematicforuniquelydefiningthisspecializedTcellsubsetinhumans.WefoundthattheIL-7receptor(CD127)isdown-regulatedonasubsetofCD4+Tcellsinperipheralblood.Wedemon...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期OraltoleranceintheabsenceofnaturallyoccurringTregs
...nflammation.Oralexposuretoantigeninduceddevelopmentofantigen-specificCD4+CD25+Foxp3+CD45RBlowcellsthatwereanergicanddisplayedsuppressiveactivityinvivoandinvitro.OraltolerancetotheTh2allergicresponsewasinlargepartdependentonTGF-?andindependentofIL-10.Interestingly,Tregswerealsoinducedbysinglei.p.immu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期Efficacyofdailyandmonthlyhigh-dosecalciferolinvitaminDdeficientnulliparousandlactatingwomen
...randomlyassignedtoconsume2000IUvitaminD2/dor60000IUvitaminD2/mofor3mo.Serum25-hydroxyvitaminD[25(OH)D]concentrationsweremeasuredbyradioimmunoassayatbaselineandeverymonth.Results:MostwomenhadvitaminDdeficiency[ie,25(OH)D50nmol/L]atstudyentry.Mean±SD25(OH)Dconcentrationsat3moweresignificantlyhigh...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第6期VitaminD:importanceinthepreventionofcancers,type1diabetes,heartdisease,andosteoporosis
...foodsnaturallycontainvitaminD,sunlightsuppliesmostofourvitaminDrequirement.25-HydroxyvitaminD[25(OH)D]isthemetabolitethatshouldbemeasuredinthebloodtodeterminevitaminDstatus.VitaminDdeficiencyisprevalentininfantswhoaresolelybreastfedandwhodonotreceivevitaminDsupplementationandinadultsofallageswhohave...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第3期HypovitaminosisDinBritishadultsatage45y:nationwidecohortstudyofdietaryandlifestylepredictors
...toevaluatetheinfluenceofkeydietaryandlifestyleriskfactors.Design:Wemeasured25-hydroxyvitaminD[25(OH)D]in7437whitesfromthe1958Britishbirthcohortwhentheywere45yold.Results:TheprevalenceofhypovitaminosisDwashighestduringthewinterandspring,when25(OH)Dconcentrations25,40,and75nmol/Lwerefoundin15.5%,46.6%...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第3期FunctionalindicesofvitaminDstatusandramificationsofvitaminDdeficiency
...treet,Suite4841,Omaha,NE68131.E-mail:rheaney{at}creighton.edu.ABSTRACTSerum25-hydroxyvitaminD3[25(OH)D3]concentrationsarecurrentlyrecognizedasthefunctionalstatusindicatorforvitaminD.Evidenceisreviewedthatshowsthatserum25(OH)D3concentrationsof80nmol/Lareassociatedwithreducedcalciumabsorption,osteopor...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第6期Higher25-hydroxyvitaminDconcentrationsareassociatedwithbetterlower-extremityfunctioninbothactiveandinactivepersonsaged60y
...rinmuscletissue.Objectives:Weinvestigatedwhetherthereisanassociationbetween25-hydroxyvitaminD[25(OH)D]concentrationsandlower-extremityfunctioninambulatoryolderpersons,whetherthatassociationdiffersbyactivitylevel,and,ifso,whetherthereisanidentifiablethresholdintheassociation.Design:Thestudywasapopula...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第3期ResurrectionofvitaminDdeficiencyandrickets
...taminD(whereDrepresentsD2orD3)isbiologicallyinertandmetabolizedintheliverto25-hydroxyvitaminD[25(OH)D],themajorcirculatingformofvitaminDthatisusedtodeterminevitaminDstatus.25(OH)Disactivatedinthekidneysto1,25-dihydroxyvitaminD[1,25(OH)2D],whichregulatescalcium,phosphorus,andbonemetabolism.VitaminDde...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期