HighprevalenceofvitaminDdeficiencyamongpregnantwomenandtheirnewbornsinnorthernIndia
...eomalaciaandhypovitaminosisDinpregnancyandincordbloodandtocorrelatematernal25-hydroxyvitaminD[25(OH)D]statuswithsunexposure,dailycalciumintake(dietaryplussupplemental),andintactparathyroidhormone(PTH)concentrations.Design:Serumcalcium,inorganicphosphorus,25(OH)D,heat-labilealkalinephosphatase,andPTH...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第5期Effectofageoncalciumabsorptioninpostmenopausalwomen
....Results:Radiocalciumabsorptiondecreasedwithage(P=0.018);itwas28%lowerinthe25womenaged75ythanintherest(P0.001).Itwassignificantlyrelatedtoserum1,25-dihydroxyvitaminD[1,25(OH)2D]inthewholesetandinboththeyoungerandoldersubsets,butitwasnotrelatedtoeither25-dihydroxyvitaminD[25(OH)D]orPTHortoanyothermea...
医源资料库;在线期刊;美国临床营养学杂志;2004年80卷第4期c-Fosproteinasatargetofanti-osteoclastogenicactionofvitaminD,andsynthesisofnewanalogs
...fNF-B(RANKL/RANK)stimulation,weshowhereinthatoraltreatmentofthesemicewith1,25-dihydroxyvitaminD3inhibitedboneresorptionandpreventedboneloss,suggestingthatVDRcountersRANKL/RANKsignaling.InM-CSF–dependentosteoclastprecursorcellsisolatedfrommousebonemarrow,1,25(OH)2D3potentlyanddose-dependentlyinhibi...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第2期Associationoflow25-hydroxyvitaminDconcentrationswithelevatedparathyroidhormoneconcentrationsandlowcorticalbonedensityinearlypubertalandpre
...BSTRACTBackground:Veryfewstudieshaveevaluatedbothparathyroidhormone(PTH)and25-hydroxyvitaminD[25(OH)D]andtheireffectsonbonemassinchildren.Objective:Westudiedtheassociationsofserum25(OH)DandintactPTH(iPTH)withbonemineralcontent(BMC)andbonemineraldensity(BMD)atdifferentbonesitesandtherelationbetweense...
医源资料库;在线期刊;美国临床营养学杂志;2003年78卷第3期Bcell–deficientNOD.H-2h4micehaveCD4+CD25+Tregulatorycellsthatinhibitthedevelopmentofspontaneousautoimmunethyroiditis
...resistanceofBcell–deficientmicetoSATwasduetotheactivityofregulatoryCD4+CD25+T(Treg)cellsactivatedifautoantigenwasinitiallypresentedonnon–Bcells,CD25+Tregcellsweretransientlydepletedinvivousinganti-CD25.Bcell–deficientNOD.H-2h4micegiventhreeweeklyinjectionsofanti-CD25developedSAT8wkafterNaIwate...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期Identificationofaninterleukin(IL)-25–dependentcellpopulationthatprovidesIL-4,IL-5,andIL-13attheonsetofhelminthexpulsion
...utmayleadtoallergyandasthmaafterinappropriateactivation.Wedemonstratethatil25–/–micedisplayinefficientNippostrongylusbrasiliensisexpulsionanddelayedcytokineproductionbyThelper2cells.Wefurtherestablishakeyroleforinterleukin(IL)-25inregulatinganovelpopulationofIL-4–,IL-5–,IL-13–producingnon...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期1,25-DihydroxyvitaminD3decreasespodocytelossandpodocytehypertrophyinthesubtotallynephrectomizedrat
【摘要】1,25(OH)2D3hasantiproliferativeeffectsandpromotescelldifferentiation.Thisconsiderationhasprovidedtherationaleforstudiesinsubtotallynephrectomizedratsshowingthat1,25(OH)2D3interferredwithglomerulosclerosis.Thecellularmechanismsinvolvedhaveremainedobscure,however.Itwasthepurposeofthepresen...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第3期Thecaseagainstergocalciferol(vitaminD2)asavitaminsupplement
...eisbasedonstudiesofricketspreventionininfantsconducted70yago.Theemergenceof25-hydroxyvitaminDasameasureofvitaminDstatusprovidesanobjective,quantitativemeasureofthebiologicalresponsetovitaminDadministration.Asaresult,vitaminD3hasproventobethemorepotentformofvitaminDinallprimatespecies,includinghumans...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第4期DefectiveregulatoryandeffectorTcellfunctionsinpatientswithFOXP3mutations
...eadboxproteinP3(FOXP3)gene.InthemousemodelofFOXP3deficiency,thelackofCD4+CD25+Tregsisresponsibleforlethalautoimmunity,indicatingthatFOXP3isrequiredforthedifferentiationofthisTregsubset.WeshowthatthenumberandphenotypeofCD4+CD25+TcellsfromIPEXpatientsarecomparabletothoseofnormaldonors.CD4+CD25highTcel...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期CD4+CD25+Tcellsprotectagainstexperimentallyinducedasthmaandalterpulmonarydendriticcellphenotypeandfunction
...iChildren‘sHospitalMedicalCenter,Cincinnati,OH45229TheroleofnaturalCD4+CD25+regulatoryT(Treg)cellsinthecontrolofallergicasthmaremainspoorlyunderstood.WeexploretheimpactofTregcelldepletionontheallergicresponseinmicesusceptible(A/J)orcomparativelyresistant(C3H)tothedevelopmentofallergen-inducedairwa...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第11期