InvivoexpansionofCD4+CD45RO–CD25+TcellsexpressingfoxP3inIL-2-treatedHIV-infectedpatients
...fIL-2toHIV-infectedpatientsleadstoexpansionofauniquesubsetofCD4+CD45RO–CD25+cells.Inthisstudy,theorigin,clonality,andfunctionofthesecellswereinvestigated.AnalysisofTCRexcisioncirclesrevealedthattheCD4+CD45RO–CD25+cellsweretheproductofperipheralexpansionbutremainedpolyclonalasdeterminedbyTCRreper...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期VitaminDstatusaffectsserumparathyroidhormoneconcentrationsduringwinterinfemaleadolescents:associationswithforearmbonemineraldensity
...eelderly.Pubertyisanimportanttimeofbonemetabolismandgrowth.Theeffectofserum25-hydroxyvitaminD[25(OH)D]concentrationsonparathyroidhormoneconcentrationsandbonemineraldensity(BMD)hasnotbeenwellstudiedcross-sectionallyinadolescents.Objective:WestudiedtheeffectofvitaminDstatusonserumintactparathyroidhorm...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第2期Estimationofoptimalserumconcentrationsof25-hydroxyvitaminDformultiplehealthoutcomes
...matology,InstituteofPhysicalMedicine,UniversityHospitalZurich,Gloriastrasse25,8091Zurich,Switzerland.E-mail:heike.bischoff{at}usz.ch.ABSTRACTRecentevidencesuggeststhatvitaminDintakesabovecurrentrecommendationsmaybeassociatedwithbetterhealthoutcomes.However,optimalserumconcentrationsof25-hydroxyvitam...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第1期LAT-mediatedsignalinginCD4+CD25+regulatoryTcelldevelopment
...iteinLAT,leadstoasevereautoimmunediseaseinmice.Inthisstudy,weshowthatCD4+CD25+TregcellsthatexpressedFoxp3transcriptionfactorwerenearlyabsentinboththymusandperipherallymphoidorgansofLATY136Fmice.ThisdefectwasnotaresultoftheautoimmuneenvironmentasLATY136FTregcellsalsofailedtodevelopinhealthyLAT–/–...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期HomeostaticmaintenanceofnaturalFoxp3+CD25+CD4+regulatoryTcellsbyinterleukin(IL)-2andinductionofautoimmunediseasebyIL-2neutralization
...vereneuropathy.SuchtreatmentselectivelyreducesthenumberofFoxp3-expressingCD25+CD4+Tcells,butnotCD25–CD4+Tcells,inthethymusandperipheryofnormalandthymectomizedmice.IL-2neutralizationinhibitsphysiologicalproliferationofperipheralCD25+CD4+Tcellsthatarepresumablyrespondingtonormalself-antigens,whereas...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第5期p38MAPK/HSP25signalingmediatescadmium-inducedcontractionofmesangialcellsandrenalglomeruli
...merularfiltration,acharacteristicofcadmiumnephrotoxicity.Becausep38MAPK/HSP25signalinghasbeenimplicatedinsmoothmusclecontraction,weexamineditsroleincadmium-inducedcontractionofmesangialcells.Wereportthatexposureofmesangialcellstocadmiumresultedin1)cellcontraction,2)activationofMAPkinases,3)increased...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第6期Cholecalciferolsignificantlyincreases25-hydroxyvitaminDconcentrationsinadultswithcysticfibrosis
...tionsisuntested.Objectives:Theaimsofthisstudyweretodeterminetheprevalenceof25-hydroxyvitaminD[25(OH)D]deficiencyinalargecohortofadultswithcysticfibrosisandtoevaluatetheeffectivenessofsupplementationwithcholecalciferol.Design:Inthisretrospectivecohortdesign,baseline25(OH)Dconcentrationsweremeasured,a...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第5期RoleofIFN-ininductionofFoxp3andconversionofCD4+CD25–TcellstoCD4+Tregs
...isnewevidenceindicatingthatIFN-iscriticallyrequiredfortheconversionofCD4+CD25–TcellstoCD4+TregsduringEAE.Inourstudy,theaddedseverityofEAEinIFN-knockoutmicewasdirectlyassociatedwithalteredencephalitogenicTcellresponses,whichcorrelatedwithreducedfrequencyandfunctionofCD4+CD25+Foxp3+Tregswhencompared...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第9期DefinitionoftargetantigensfornaturallyoccurringCD4+CD25+regulatoryTcells
...nter,NewYork,NY10021TheantigenictargetsrecognizedbynaturallyoccurringCD4+CD25+regulatoryTcells(Tregcells)havebeenelusive.Wehaveserologicallydefinedaseriesofbroadlyexpressedself-antigensderivedfromchemicallyinducedmousesarcomasbyserologicalidentificationofantigensbyrecombinantexpressioncloning(SEREX)...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第5期Expressionofinterleukin(IL)-2andIL-7receptorsdiscriminatesbetweenhumanregulatoryandactivatedTcells
...ia7TheChildren‘sHospitalatWestmead,NSW2145,AustraliaAbnormalitiesinCD4+CD25+Foxp3+regulatoryT(Treg)cellshavebeenimplicatedinsusceptibilitytoallergic,autoimmune,andimmunoinflammatoryconditions.However,phenotypicandfunctionalassessmentofhumanTregcellshasbeenhamperedbydifficultyindistinguishingbetwee...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期