Prevalenceandfunctionalsignificanceof25-hydroxyvitaminDdeficiencyandvitaminDreceptorgenepolymorphismsinAsianIndians
...inAsianIndians.Objective:Theobjectivewastoassessthefunctionalsignificanceof25-hydroxyvitaminD[25(OH)D]deficiency,vitaminDreceptor(VDR)gene,andparathyroidhormone(PTH)genepolymorphismsinrelationtobonemineraldensity(BMD)inurbanAsianIndians.Design:Serumtotalcalcium,inorganicphosphorus,alkalinephosphatas...
医源资料库;在线期刊;美国临床营养学杂志;2006年83卷第6期1,25-(OH)2D3及其类似物在自身免疫性疾病中的免疫调节作用
【摘要】1,25-二羟基维生素D3是维生素D的生物学活化形式,它经维生素D受体介导,除了调节钙磷代谢外,还能影响多种细胞生长分化,在调节免疫系统功能中具有重要作用。1,25-二羟基维生素D3及其类似物通过调节树突状细胞...
合作平台;在线期刊;中华实用医药杂志;2004年第4卷第11期;综述EndogenousIRBPcanbedispensableforgenerationofnaturalCD4+CD25+regulatoryTcellsthatprotectfromIRBP-inducedretinalautoimmunity
...hotoreceptorretinoid-bindingprotein(IRBP),iscontrolledby“natural“CD4+CD25+regulatoryT(Treg)cells.ToexaminewhetherendogenousexpressionofIRBPisnecessarytogeneratetheseTregcells,westudiedresponsesofIRBPknockout(KO)versuswild-type(WT)mice.Unexpectedly,notonlyWTbutalsoIRBPKOmiceimmunizedwithauveitoge...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期DecreasedbioavailabilityofvitaminDinobesity
...,white,obese[bodymassindex(BMI;inkg/m2)30]andmatchedleancontrolsubjects(BMI25)receivedeitherwhole-bodyultravioletradiationorapharmacologicdoseofvitaminD2orally.Results:Obesesubjectshadsignificantlylowerbasal25-hydroxyvitaminDconcentrationsandhigherparathyroidhormoneconcentrationsthandidage-matchedco...
医源资料库;在线期刊;美国临床营养学杂志;2000年72卷第3期CoactivationoftheHumanVitaminDReceptorbythePeroxisomeProliferator-ActivatedReceptorCoactivator-1
...belongstothesuperfamilyofsteroid/thyroidhormonereceptorsthatisactivatedby1,25-dihydroxyvitaminD3.Traditionaltargetsfor1,25-dihydroxyvitaminD3actionincludetissuesinvolvedinthemaintenanceofcalciumhomeostasisandbonedevelopmentandremodeling.Peroxisomeproliferator-activatedreceptorcoactivator-1(PGC-1),at...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期Novel5-Flucytosine-ResistantCladeofCandidadubliniensisfromSaudiArabiaandEgyptIdentifiedbyCd25Fingerprinting
...AfingerprintingofCandidadubliniensisisolatesusingthespecies-specificprobeCd25previouslyshowedthatthisspeciesconsistsoftwodistinctgroups,termedCd25groupIandCd25groupII.Thepresentstudyinvestigatedthepopulationstructureof30C.dubliniensisoralisolatesfromSaudiArabiaandEgyptusingCd25fingerprintingandrRNAg...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期过敏性紫癜病儿急性期免疫细胞功能变化
...组外周血CD3+细胞、CD4+细胞、CD8+细胞、CD4+/CD8+比值、CD4+CD25+细胞、NK细胞(CD16+CD56+)和B淋巴细胞(CD19+)水平。结果HSPN组和NHSPN组外周血CD3+细胞、CD4+细胞、CD4+/CD8+比值、CD4+CD25+细胞和NK细胞水平较对照组显著降低,CD8+细胞和B淋...
医源资料库;在线期刊;齐鲁医学杂志;2010年第25卷第2期Nutrition,mildhyperparathyroidism,andbonemineraldensityinyoungJapanesewomen
...eMinistryofEducation,Culture,Sports,ScienceandTechnologyofJapan.Thestandard25(OH)D3wasagiftfromFHoffmann-LaRocheLtd(Basel,Switzerland).3AddressreprintrequeststoKNakamura,DivisionofSocialandEnvironmentalMedicine,DepartmentofCommunityPreventiveMedicine,NiigataUniversityGraduateSchoolofMedicalandDental...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第5期PotentiallymodifiabledeterminantsofvitaminDstatusinanolderpopulationintheNetherlands:theHoornStudy
...g538whiteDutchmenandwomenaged60–87y.VitaminDstatuswasassessedbyplasma25-hydroxyvitaminD[25(OH)D]concentrations.Results:Inthewinterperiod,51%ofthesubjectshad25(OH)Dconcentrations50.0nmol/L.GreaterbodyfatnessandlesstimespentonoutdoorphysicalactivitywereassociatedwithworsevitaminDstatus.Regularus...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第3期PossibleinvolvementofpregnaneXreceptor–enhancedCYP24expressionindrug-inducedosteomalacia
...anismofthisprocessisunknown.Hereweshowthatthesedrugsleadtotheupregulationof25-hydroxyvitaminD3-24-hydroxylase(CYP24)geneexpressionthroughtheactivationofthenuclearreceptorpregnaneXreceptor(PXR;NR1I2).CYP24isamitochondrialenzymeresponsibleforinactivatingvitaminDmetabolites.CYP24mRNAisupregulatedinvivo...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第1期