HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling
...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues
...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期Shiftinggears:liverSR-BIdrivesreversecholesteroltransportinmacrophages
...ofecesisobservedinmiceoverexpressinghepaticscavengerreceptorclassBtypeI(SR-BI),whereasinSR-BI–knockoutmice,cholesterolclearanceisdiminished.ThestudydemonstratesthathepaticSR-BIisapositiveregulatorofmacrophageRCTinvivo.Seetherelatedarticlebeginningonpage2870Thetransportofexcesscholesterolfromtheper...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期Youarerighttoo!
...herelatedarticlebeginningonpage2192InthesmallvillagesofeasternEurope,therabbiwastheundisputedleaderoftheJewishpeopleofhisvillage.Notonlywashethemasterofreligiouswisdomandlaw,butheoftenservedasthearbiterofcivildisputesaswell.Thereistoldthetaleof2individualswhohadamajordisputeandagreedtogototherabbifo...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期GenotypicStudyofPneumocystisjiroveciiinHumanImmunodeficiencyVirus-PositivePatientsinThailand
DepartmentofMicrobiology,FacultyofScience,MahidolUniversityRamaVIRd.DepartmentofParasitology,PhramongkutklaoCollegeofMedicine,RatchawithiRd.,Bangkok10400CenterforBiotechnologyandDepartmentofBiotechnology,InstituteofScienceandTechnologyforResearchandDevelopment,MahidolUniversity,Salaya,Nakornpratom73...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第5期海南省2007年登革热媒介伊蚊分布调查
...)、容器指数(ContainerIndex,CI)、布雷图指数(BreteauIndex,BI)等,以房屋指数、容器指数和布雷图指数,调查媒介幼虫密度;以捞取积水容器内蚊幼,调查孳生情况。结果全省BI值最高为123,最低为13.3,全省平均BI值37.4;CI值最...
医源资料库;在线期刊;中国热带医学杂志;2008年第8卷第12期Puttingcholesterolinitsplace:apoEandreversecholesteroltransport
...atsuuraetal.revealsnewfeaturesofthispathway,includingtheimportanceoftheATP-bindingcassettetransporterG1inmacrophagesandapoEincholesteryleffluxfromcellstocholesterolester–rich(CE-rich)HDL2acceptors.OneproposalforboostingreversecholesteroltransporthasbeentoelevateplasmaHDLlevelsbyinhibitingCEtransfe...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期Saturatedfat–richdietenhancesselectiveuptakeofLDLcholesterylestersinthearterialwall
...tofPathology,InstituteofHumanNutrition,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NewYork,USA.AbstractPlasmaLDLlevelsandatherosclerosisbothincreaseonasaturatedfat–rich(SAT)diet.LDLcholesteroldeliverytotissuemayoccurviauptakeoftheLDLparticlesorviaselectiveuptake(SU),whereincholestery...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期Targetedandrestrictedcomplementactivationonacrosome-reactedspermatozoa
...ascadeefficientlythroughC3butnotbeyond.UsingFACStosimultaneouslyevaluateviability,acrosomalstatus,andcomplementdeposition,wefoundthatcomplementactivationwasinitiatedbyC-reactiveprotein(CRP)andwasC1q,C2,andfactorBdependent.Thispatternisconsistentwithengagementoftheclassicalpathwayfollowedbyamplificat...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期