HPLC法测定前列腺素E2凝胶剂的含量
...生产的阴道剂,其有效成分前列腺素E2(ProstaglandinE2,简称PGE2)具有引起子宫平滑肌收缩,调节子宫、阴道对其它激素刺激的反应等一系列药理作用,临床上用于引产[1,2]。厂附检验标准采用液相色谱柱后衍生化法测定,必须...
药品天地;专业药学;实验技术;色谱技术;色谱论文HPLC法测定前列腺素E2凝胶剂的含量
...生产的阴道剂,其有效成分前列腺素E2(ProstaglandinE2,简称PGE2)具有引起子宫平滑肌收缩,调节子宫、阴道对其它激素刺激的反应等一系列药理作用,临床上用于引产[1,2]。厂附检验标准采用液相色谱柱后衍生化法测定,必须...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例ArginaseIinmyeloidsuppressorcellsisinducedbyCOX-2inlungcarcinoma
...llsconstitutivelyexpresscyclooxygenase(COX)-1andCOX-2andproducehighlevelsofPGE2.GeneticandpharmacologicalinhibitionofCOX-2,butnotCOX-1,blockedarginaseIinductioninvitroandinvivo.SignalingthroughthePGE2receptorE-prostanoid4expressedinMSCsinducedarginaseI.Furthermore,blockingarginaseIexpressionusingCOX...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期前列腺素E1治疗重症肺炎肺动脉高压的临床观察及护理
...停用PGE1后皮疹即可自行消退。极个别患儿尚可出现烦躁不安,护士应守护床边,并加用床栏或约束带,必要时可适当使用镇静剂,以防患儿坠床等意外。 4讨论 PGE1是前列腺环素的衍生物,具有代谢快、半衰期短的特性,...
资料库;在线期刊;中华现代儿科学杂志;2005年第2卷第4期ImpairedSystemicProductionofProstaglandinE2inChildrenwithCerebralMalaria
...oryresponsestoinfection.Ourrecentstudieshaveshownthatplasmalevelsofbicyclo-PGE2(astableendproductofPGE2metabolism)andleukocytecyclooxygenase(COX)2geneexpressionaresuppressedinchildrenwithmalarialanemia.SincetheroleofPGsasimmunomodulatorsofhumancerebralmalaria(CM)hasnotbeenexamined,weinvestigatedurin...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第9期CXCL1inducedbyprostaglandinE2promotesangiogenesisincolorectalcancer
...ell-knownriskfactorforcancer.ProinflammatorymediatorssuchasprostaglandinE2(PGE2)promotecolorectaltumorgrowthbystimulatingangiogenesis,cellinvasion,andcellgrowth,andinhibitingapoptosis.Moleculesthatregulatetumor-associatedangiogenesisprovidepromisingtherapeutictargetsfortreatmentofcolorectalcancer(CR...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期Grp78isessentialfor11-deoxy-16,16-dimethylPGE2-mediatedcytoprotectioninrenalepithelialcells
【摘要】11-Deoxy-16,16-dimethylPGE2(DDM-PGE2)protectsrenalproximaltubuleepithelialcells(LLC-PK1)againstthetoxicityinducedby2,3,5-tris(glutathion-S-yl)hydroquinone(TGHQ),apotentnephrotoxicandnephrocarcinogenicmetaboliteofhydroquinone.WehavenowdeterminedtheabilityofDDM-PGE2toprotectagainstotherren...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期SelectivityofcyclooxygenaseisoformactivityandprostanoidproductioninnormalanddiseasedHan:SPRD-cyratkidneys
...anoidproduction[thromboxaneB2(TXB2,stablemetaboliteofTXA2),prostaglandinE2(PGE2),and6-keto-prostaglandinF1(6-keto-PGF1,stablemetaboliteofPGI2)]innormalanddiseasedkidneys.Indiseasedkidneys,COX-1-immunoreactiveproteinandmRNAlevelswerehigherandCOX-2levelswerelowercomparedwithnormalkidneys.Incontrast,CO...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第4期SpinalinflammatoryhyperalgesiaismediatedbyprostaglandinEreceptorsoftheEP2subtype
...gesia),providesastrategyforbetter-toleratedanalgesics.Here,wehaveidentifiedPGE2receptorsoftheEP2receptorsubtypeaskeysignalingelementsinspinalinflammatoryhyperalgesia.MicedeficientinEP2receptors(EP2–/–mice)completelylackspinalPGE2-evokedhyperalgesia.Afteraperipheralinflammatorystimulus,EP2–/–...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第3期CoordinatecontrolofprostaglandinE2synthesisanduptakebyhyperosmolarityinrenalmedullaryinterstitialcells
...legeofMedicine,Bronx,NewYorkABSTRACTDuringwaterdeprivation,prostaglandinE2(PGE2),formedbyrenalmedullaryinterstitialcells(RMICs),feedbackinhibitstheactionsofantidiuretichormone.InterstitialPGE2concentrationsrepresentthenetofbothPGE2synthesisbycyclooxygenase(COX)andPGE2uptakebycarrierssuchasPGT.Weused...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第2期