Tcellhyperactivityinlupusasaconsequenceofhyperstimulatoryantigen-presentingcells
...itro,andinvivo,followingantigenchallenge.Indeed,continuedTcellexpansionwasnotedeveninresponsetoatolerogenicsignal.However,thesephenotypesdidnotappeartobeTcellintrinsicbutweredictatedbyhyperstimulatoryB6.Sle3APCs.Importantly,B6.Sle3-derivedDCsandmacrophagesappearedtobesignificantlymoremature/activate...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期SOCS-1regulatesIL-15–drivenhomeostaticproliferationofantigen-naiveCD8Tcells,limitingtheirautoimmunepotential
...hdiseaseonsetissubstantiallyfasterwithapolyclonalTcellrepertoire.AmajorphenotypeofSOCS-1–/–miceistheaccumulationofCD44highCD8+peripheralTcells.WeshowthatSOCS-1–deficientCD8,butnotCD4,Tcellsproliferatewhentransferredintonormal(Tcell–sufficient)mice,andthatthisisdependentontwosignals:interleuk...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第8期DurationoftheinitialTCRstimuluscontrolsthemagnitudebutnotfunctionalityoftheCD8+Tcellresponse
...gton,Seattle,WA98195CD8+Tcellsonlyrequireabriefstimulationwithantigeninvitrotodivideanddifferentiateintoeffectorandmemorycellsupontransferinvivo.Theefficiencyofclonalexpansionandthefunctionalcharacteristicsofmemorycellsderivedfrombrieflystimulatedcellsarepoorlydefined.Wedevelopedasystemthatallowedus...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期Tcellreceptorengagementbypeptide–MHCligandsinducesaconformationalchangeintheCD3complexofthymocytes
...nses.Toachievethis,thenonsignalingheterodimercommunicatesligandrecognitiontotheCD3signalingsubunitsbyanunknownmechanism.Inthymocytes,wefoundthatbothpositive-andnegative-selectingpMHCligandsexposeacrypticepitopeintheCD3complexuponTCRengagement.Thisconformationalchangeisinducedinvivoandrequirestheexpr...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期CompletedifferentiationofCD8+Tcellsactivatedlocallywithinthetransplantedliver
...enceofliverinfections,suchasmalariaandviralhepatitis.Thesephenomenahaveledtothehypothesisthatantigenpresentationwithintheliverisabortive,leadingtoTcelltoleranceorapoptosis.Herewetestthishypothesisinanoptimizedorthotopiclivertransplantationmodel.Indirectcontradictiontothismodel,theliveritselfinducesf...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期NeonatalFcreceptorforIgGregulatesmucosalimmuneresponsestoluminalbacteria
...ospital,Boston,Massachusetts,USA.5DivisionofClinicalBioregulatoryScience,KyotoUniversity,Kyoto,Japan.6TheJacksonLaboratory,BarHarbor,Maine,USA.7GastrointestinalCellBiology,DepartmentofMedicine,Children’sHospital,Boston,Massachusetts,USA.8HarvardDigestiveDiseaseCenter,Boston,Massachusetts,USA.Abstr...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第8期BLT1-mediatedTcelltraffickingiscriticalforrejectionandobliterativebronchiolitisafterlungtransplantation
...ology,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA02115LeukotrieneB4isalipidmediatorthatrecentlyhasbeenshowntohavepotentchemotacticactivityforeffectorTlymphocytesmediatedthroughitsreceptor,BLT1.Here,wedevelopedanovelmurinemodelofacutelungrejectiontodemonstratethatBLT1controlseffector...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第1期DualPotentiatingandInhibitoryActionsofaBenz[e]indeneNeurosteroidAnalogonRecombinant122GABAAReceptors
...fdesensitization.Fromsingle-channelrecordings,weestimatethattheentryrateintotheinhibitedorblockedstate,k+B,is0.50µM-1s-1.Basedonthekineticmechanismofaction,andthefindingthatthiseffectisblockedbythe1V256Smutation,weproposethatBI-2actsthroughaninhibitorysitefirstpostulatedfortheinhibitoryneurost...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期EthanolModulatestheInteractionoftheEndogenousNeurosteroidAllopregnanolonewiththe122LGABAAReceptor
...oapplicationof0.1to1%(17-170mM)ethanolinfluencedreceptormodulationby35Pbutnotthatbypregnenolonesulfateor-estradiol.Oneofthethreekineticeffectsevidentinchannelpotentiationby35P,prolongationofthelongest-livedopentimecomponent(OT3),wasaffectedbyethanolwiththemidpointofitsdose-responsecurvemovedtolowers...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第2期DynamicChangesDuringtheImmuneResponseinTCell–Antigen-presentingCellClustersIsolatedfromLymphNodes
...yinvariantregardlessoftheTcelllineage,themajorhistocompatibilitycomplexhaplotype,andtheantigendose.Interestingly,initiationofcelldivisionofTcellsspecificforasubdominantepitopeandaweakagonistwasdelayedby6h.Theresultsprovideabasisfortheanalysisofshortrange,mutualcell–cellinteractionswithinsuchconfin...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期