Reticulocyte15-Lipoxygenase-IIsImportantinAcetylcholine-InducedEndothelium-DependentVasorelaxationinRabbitAorta
【摘要】Objective-Aortic15-lipoxygenase(15-LO)metabolizesarachidonicacid(AA)to15-hydroperoxyeicosatetraenoicacid,whichisthenconvertedtothevasodilators15-hydroxy-11,12-epoxyeicosatrienoicacidand11,12,15-trihydroxyeicosatrienoicacid.Thesemetabolitescontributetoendothelium-dependentrelaxationsofrab...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期HostcontrolofMycobacteriumtuberculosisisregulatedby5-lipoxygenase–dependentlipoxinproduction
1ImmunobiologySection,LaboratoryofParasiticDiseases,NationalInstituteofAllergyandInfectiousDiseases(NIAID),NIH,Bethesda,Maryland,USA.2LaboratoriodeImunorregulacaoeMicrobiologia,CentrodePesquisasGoncaloMoniz,Funda??oOswaldoCruz,Salvador,Bahia,Brazil.3CenterforExperimentalTherapeuticsandReperfusionInj...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期蛇毒抗高凝状态酶、氟尿嘧啶对BEL-7404细胞作用的实验研究*
...嘧啶(5-FU)对人肝癌细胞BEL-7404(简称7404细胞)、正常LO2肝细胞(简称LO2细胞)作用的比较,研究AHCSE对肝癌的作用以及探讨其可能的作用机制。方法应用光学显微镜、透射电镜、MTT法、TUNEL、FCM等方法观察7404细胞、LO2细胞经过AH...
医源资料库;在线期刊;中华现代外科学杂志;2005年第2卷第21期5-LipoxygenaseDeficiencyPreventsRespiratoryFailureduringVentilator-inducedLungInjury
...reasedefficiencyofgasexchange.Hypoxicpulmonaryvasoconstriction(HPV)directsbloodflowtowell-ventilatedlungregions,preservingsystemicoxygenationduringpulmonaryinjury.Recentexperimentalstudieshaverevealedanimportantroleforleukotriene(LT)biosynthesisby5-lipoxygenase(5LO)intheimpairmentofHPVbyendotoxin.Ob...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第8期TheAminosteroidPhospholipaseCAntagonistU-73122(1-[6-[[17--3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione)PotentlyInhibitsHuma
...failedtosuppressresponsesinducedbyionomycinorthapsigargin.5-Lipoxygenase(5-LO)isaCa2+-regulatedenzymethatcanbeactivatedinleukocytesbystimulithatelevate[Ca2+]i.AttemptstoinvestigatetheinvolvementofPLCincellular5-LOactivationrevealedthatU-73122suppresses5-LOproductsynthesisregardlessofthestimulusandin...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期CD127expressioninverselycorrelateswithFoxP3andsuppressivefunctionofhumanCD4+Tregcells
...cisco,SanFrancisco,CA941432DepartmentofPediatricsandMedicine,UniversityofColoradoHealthSciencesCenter,Denver,CO802623Affymetrix,Inc.,SantaClara,CA950514CentenaryInstituteofCancerMedicineandCellBiology,FacultyofMedicine,UniversityofSydney,NewSouthWales2042Australia5DepartmentofPediatrics,StanfordUniv...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期MCB:高脂饮食是诱发糖尿病的罪魁祸首
...来自美国印第安纳大学医学院研究人员最近研究发现:12-LO酶是促进胰腺细胞发生肥胖诱导的氧化应激,导致糖尿病前期和糖尿病的罪魁祸首。这一发现将有助开发可以干扰这种酶的药物,防止甚至逆转糖尿病的发展。这项研究...
行业资讯;临床快报;糖尿病相关白酒气相色谱分析法
...以防挥发) ●混标的配制: 分别用移液管吸取标样lOmL和内标5mL,用55%-60%(V/V)的乙醇定容到1OOmL,混匀后(可分装)待用。 混标中各组分i及内标含量计算公式: mi=ci×Vi×di×lO00 ms=cs×Vs×ds×lO00 式中:mi/ms—混...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例12/15LipoxygenaseMediatesMonocyteAdhesiontoAorticEndotheliuminApolipoproteinE-DeficientMiceThroughActivationofRhoAandNF-B
【摘要】Objectives-12/15lipoxygenase(12/15LO)hasbeenimplicatedasamediatorofinflammationandatherosclerosis.Inthecurrentstudy,weidentifiedmechanismsthroughwhich12/15LOmediatesmonocyte:endothelialinteractionsinvivoinapolipoproteinE-deficientmice(apoEKO),awell-characterizedmousemodelofatherosclerosi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第6期AssociationBetween5-LipoxygenaseExpressionandPlaqueInstabilityinHumans
FromtheAtherosclerosisPreventionCenter(F.Cipollone,A.M.,M.L.F.,C.C.,A.I.,S.U.,F.S.,M.B.,F.Cuccurullo),“G.d’Annunzio“UniversityofChieti,andtheClinicalResearchCenter,“G.d’Annunzio“UniversityFoundation,Chieti,Italy;andtheHuntsmanCancerInstitute(S.M.P.,D.M.S.),UniversityofUtah,SaltLakeCity.C...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第8期