VSIG4,aB7family–relatedprotein,isanegativeregulatorofTcellactivation
...aveidentifiedapreviouslyunknownfunctionforB7family–relatedproteinV-setandIgdomain–containing4(VSIG4).InvitroexperimentsusingVSIG4-IgfusionmoleculesshowedthatVSIG4isastrongnegativeregulatorofmurineandhumanTcellproliferationandIL-2production.AdministrationtomiceofsolubleVSIG4-Igfusionmoleculesredu...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期Tim-2regulatesThelpertype2responsesandautoimmunity
1DepartmentofNeurology,CenterforNeurologicDiseases,BrighamandWomen‘sHospitalandHarvardMedicalSchool,Boston,MA021152VAHealthCareSystem,PaloAlto,CA943043DepartmentofPathology,StanfordUniversitySchoolofMedicine,Stanford,CA953054DivisionofImmunology,BethIsraelDeaconessMedicalCenter,HarvardMedicalSchoo...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第3期TargetedcomplementinhibitionbyC3drecognitionamelioratestissueinjurywithoutapparentincreaseinsusceptibilitytoinfection
...wereportontheuseofamousemodelofintestinalischemia/reperfusioninjurytoinvestigatethestrategyoftargetingcomplementinhibitiontositesofcomplementactivationbylinkinganiC3b/C3dg-bindingfragmentofmousecomplementreceptor2(CR2)toamousecomplement-inhibitoryprotein,Crry.WeshowthatthenovelCR2-Crryfusionproteint...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期SimilaritiesanddifferencesbetweenselectiveandnonselectiveBAFFblockadeinmurineSLE
...heircapacitytoproduceantibodies.Bcelldepletioniscurrentlyunderintenseinvestigationasatherapeuticstrategyforautoimmunediseases.TheTNFfamilymembersBcell–activatingfactoroftheTNFfamily(BAFF)anditshomologAproliferation-inducingligand(APRIL)areBcellsurvivalanddifferentiationfactorsandarethereforeration...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期TobeornottobeB7
...nddevelopmentofadaptiveimmuneresponsesisinitiatedbytheengagementofTCRsbyantigenicpeptide–MHCcomplexesandshapedattheclonallevelbybothpositiveandnegativecostimulatorysignals.TheB7familymembersareinvolvedatseveralstagesinthisprocess.InthisissueoftheJCI,Vogtetal.showthattheB7family–relatedproteinV-s...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期T-independenttypeIIimmuneresponsesgeneratememoryBcells
...University,NewYork,NY10021UnlikeT-dependentimmuneresponsesagainstproteinantigens,T-independentresponsesagainstpolysaccharidesconferlong-lastinghumoralimmunityintheabsenceofrecallresponsesandarenotknowntogeneratememoryBcells.HerewereportthatpolysaccharideantigenselicitmemoryBcellsthatarephenotypicall...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第2期LymphangiogenicGrowthFactorResponsivenessIsModulatedbyPostnatalLymphaticVesselMaturation
...arecombinantadenovirusencodingasolubleformoftheirreceptorVEGFR-3(AdVEGFR-3-Ig),westudiedlymphaticvesseldependencyonVEGF-CandVEGF-DinducedVEGFR-3signalinginpostnatalandadultmice.TransductionwithAdVEGFR-3-Igledtoregressionoflymphaticcapillariesandmedium-sizedlymphaticvesselsinmiceunder2weeksofagewitho...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期IgtyrosineresiduescontributetothecontrolofBcellreceptorsignalingbyregulatingreceptorinternalization
...ofNeonatology,NewYorkUniversityMedicalSchool,NewYork,NY10016Immunoglobulin(Ig)andIginitiateBcellreceptor(BCR)signalingthroughimmunereceptortyrosineactivationmotifs(ITAMs)thataretargetsofSH2domain–containingkinases.ToexaminethefunctionofIgITAMtyrosineresidesinmatureBcellsinvivo,weexchangedtheseresi...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期Lossoftheproapoptoticprotein,Bim,breaksBcellanergy
...ofColoradoHealthSciencesCenter,Denver,CO80206AlthoughBcellsthatrespondwithhighaviditytoself-antigenareeliminatedearlyintheirdevelopment,manyautoreactiveBcellsescapeeliminationandaretolerizedlaterintheirlivesviaanergy.AnergicBcellsareunresponsivetoantigenanddieprematurely.Ithasbeensuggestedthatthepro...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期角质细胞生长因子及其防护作用的研究
...KGFR的配体结合区除信号肽外,还含有2个或3个免疫球蛋白(Ig)样结构域,在IgⅠ和IgⅡ结构之间含有主要由天冬氨酸和谷氨酸等8个氨基酸构成的酸性氨基酸序列。在第三个Ig样结构中有一部分呈突起状。第一个被克隆出来的KGFR含有Ig...
医源资料库;在线期刊;滨州医学院学报;2007年第30卷第3期