Maternalmethylenetetrahydrofolatereductasedeficiencyandlowdietaryfolateleadtoadversereproductiveoutcomesandcongenitalheartdefectsinmice
...thdelay,andcongenitalheartdefects.Results:PlasmahomocysteineinMthfr+/damsandinFADD-treateddamswassignificantlyhigherthanthatinMthfr+/+damsandCD-treateddams,respectively.AsignificantlyhigherrateofresorptionandgreaterdevelopmentaldelaywereobservedinhyperhomocysteinemicmicethaninCD-treated+/+dams...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第1期表观遗传学热点酶的作用机制
加州大学圣芭芭拉分校的研究人员发现大肠杆菌的Dam酶在DNA上移动进行修饰时会发生“跳跃”,并对其物理特性和行为进行了分析,这一研究成果能为生物医学研究和其他科学应用提供帮助。该文章发表在JournalofBiologicalChemistry...
行业资讯;临床快报;遗传与基因组TransgenicOverexpressionofADAMSuppressesMuscleRegenerationandAggravatesDystrophyinAgedmdxMice
...storationandgradualreplacementoftheskeletalmusclebyfatandconnectivetissue.ADAM12haspreviouslybeenshowntoalleviatethepathologyofyoungdystrophin-deficientmdxmice,amodelforDuchennemusculardystrophy.TheobservedeffectofADAM12wassuggestedtobemediatedviaamembrane-stabilizingup-regulationofutrophin,7Bintegr...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第11期ChemokinesinChildrenWithHeterozygousFamiliarHypercholesterolemia
...wentyhealthysubjectsofthesamesexandage,withouthypercholesterolemia,recruitedamongfriendsoftheFHchildren,wereaskedtotakepartinthestudyasacontrolgroup(Table).AlloftheFHchildrenwereclinicallyhealthywithoutanydiagnosisofCVD,andnonewereusingstatins.Notalloftheanalyseswereperformedinallofthechildrenbecaus...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期预防性颅内放疗应是对化疗有反应之SCLC的标准治疗
...示,预防性颅内放射线治疗应该是所有对起始化学治疗有反应之小细胞肺癌(SCLC)病患的标准治疗;该项试验结果显示,预防性颅内放疗显著降低脑部转移发生率、与延长免于疾病与整体存活时间。 这项研究由荷兰阿...
行业资讯;临床快报;肿瘤相关2015年诺贝尔化学奖揭晓
...性内切酶EcoRI开展研究。1970年代末,Paul的研究兴趣转向Dam甲基化酶时,一不小心又再次撞进了另外一个DNA相关研究。Dam甲基化酶负责DNA与甲基成分结合。Paul的研究展示,这些甲基成分可以充当指示牌作用,帮助特定限制性内切...
医药经济;生物技术;技术要闻ADisintegrinandMetalloprotease33PolymorphismsandLungFunctionDeclineintheGeneralPopulation
...roningen,TheNetherlandsABSTRACTRationale:Adisintegrinandmetalloprotease33(ADAM33)hasbeenidentifiedasasusceptibilitygeneforasthmaandsinglenucleotidepolymorphisms(SNPs)inthisgenehavebeenassociatedwithexcessivedeclineoflungfunctioninindividualswithasthma.Objectives:ToassesswhetherSNPsinADAM33areassocia...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第8期ADAM33ExpressioninAsthmaticAirwaysandHumanEmbryonicLungs
...Hospital,Southampton,UnitedKingdomABSTRACTRationale:PolymorphicvariationinADAM33(ADisintegrinAndMetalloprotease)isstronglyassociatedwithasthmaandbronchialhyperresponsivenessindifferentpopulations.ObjectiveandMethods:TostudytheroleofADAM33inasthma,weinvestigateditsexpressioninnormal,asthmatic,andembr...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第5期恩丹西酮治疗化疗药所致呕吐疗效观察
...。【关键词】恩丹西酮;止呕效果呕吐是化疗最常见的副反应,不同的化疗药物引起的呕吐程度不同,如DAM、CTX等强刺激性化疗药物易导致严重的呕吐,可引起水、电解质平衡失调和代谢性碱中毒,亦可引血钾、低血钙症,给病...
医源资料库;在线期刊;中华医药杂志;2006年第6卷第9期SupplementationofCHROMagarCandidaMediumwithPal‘sMediumforRapidIdentificationofCandidadubliniensis
...delPaísVasco,Apartado699,E-48080Bilbao,Vizcaya,SpainABSTRACTCHROMagarCandidamediumisusedfortheisolationandidentificationofCandidaspecies,butitdoesnotdifferentiateCandidaalbicansfromCandidadubliniensis.ThisdifferentiationcanbeachievedbyusingPal‘sagar,whichcannotbeusedinprimaryisolation.Wehavecombi...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第11期