YM-244769,aNovelNa+/Ca2+ExchangeInhibitorThatPreferentiallyInhibitsNCX3,EfficientlyProtectsagainstHypoxia/Reoxygenation-InducedSH-SY5YNeuronal
...R7943),protectedagainsthypoxia/reoxygenation-inducedcelldamageinneuronalSH-SY5Ycells,whichexpressNCX1andNCX3,moreefficientlythanthatinrenalLLC-PK1cells,whichexclusivelyexpressNCX1,whereas2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylicacidethylester(SN-6)suppressedrenalcelldamagetoagreaterdeg...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期Long-TermMorphineTreatmentEnhancesProteasome-DependentDegradationofGinHumanNeuroblastomaSH-SY5YCells:CorrelationwithOnsetofAdenylateCyclase
...associatedwithlong-termmorphinetreatmentinarecombinanthumanneuroblastomaSH-SY5Yclone(sc2)stablyoverexpressingthehumane?opioid(MOP)receptor.InMOPreceptor-overexpressingsc2cells,short-termmorphineexposurewasfoundtobemuchmorepotentandefficaciousininhibitingforskolin-elicitedproductionofcAMP,andlong-ter...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第2期PerturbationofDopamineMetabolismby3-Amino-2-(4‘-halophenyl)propenesLeadstoIncreasedOxidativeStressandApoptoticSH-SY5YCellDeath
...tuent.Moreimportantly,thesederivativesarehighlytoxictohumanneuroblastomaSH-SY5YbutnottoxictoM-1,HepG2,orhumanembryonickidney293non-neuronalcellsatsimilarconcentrations.Theydrasticallyperturbdopamine(DA)uptakeandmetabolisminSH-SY5Ycellsundersublethalconditionsandareabletodepletebothvesicularandcytoso...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期CriticalRoleforSphingosineKinase-1inRegulatingSurvivalofNeuroblastomaCellsExposedtoAmyloid-βPeptide
...e/sphingosine1-phosphate(S1P)biostat,intheregulationofdeathandsurvivalofSH-SY5Yneuroblastomacellsinresponsetoamyloidβ(Aβ)peptide(25-35).UponincubationwithAβ,SH-SY5Ycellsdisplayedamarkeddown-regulationofSphK1activitycoupledwithanincreaseintheceramide/S1Pratiofollowedbycelldeath.Thismec...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期NovelAntibody-LectinEnzyme-LinkedImmunosorbentAssayThatDistinguishesPrionProteinsinSporadicandVariantCasesofCreutzfeldt-JakobDisease
...ybelievedthatinthehumanbrain,PrPCspeciesarepresentinthreeglycoforms:diglycosylated,monoglycosylated,andunglycosylated.Morerecently,usingapanelofanti-PrPCmonoclonalantibodies(MAbs)thatreactwithdifferentregionsofthePrPC,wefoundthattheexpressionofPrPCinnormalbrainisfarmorecomplexthanthethree-bandpatter...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期AdiponectinSNP276isassociatedwithobesity,themetabolicsyndrome,anddiabetesintheelderly
...linicalMedicine,CollegeofMedicine,NationalTaiwanUniversity,Taipei,Taiwan(W-SY,C-LC,andJ-YL);theDepartmentsofInternalMedicine(W-SY,I-LW,J-YL,andT-YT)andLaboratoryMedicine(J-YL),NationalTaiwanUniversityHospital,Taipei,Taiwan;theInstituteofBiomedicalSciences,AcademiaSinica,Taipei,Taiwan(W-SY);andtheDep...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第2期NeuropeptideFF(NPFF)AnalogsFunctionallyAntagonizeOpioidActivitiesinNPFF2Receptor-TransfectedSH-SY5YNeuroblastomaCells
...thecellularantiopioidactivityofneuropeptideFF(NPFF),wehavetransfectedtheSH-SY5Yneuroblastomacellline,whichexpressese?and-opioidreceptors,withthehumanNPFF2receptor.Theselectedclone,SH2-D9,expressedhigh-affinityNPFF2receptorsinthesamerangeorderase?and-opioidreceptors(100eC300fmol/mgofprotein).TheNPFFa...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第3期RegulationofAutophagybyExtracellularSignal-RegulatedProteinKinasesDuring-Methyl--Phenylpyridinium-InducedCellDeath
...pyridineinmammals.Here,wedemonstratethatMPP+elicitedincreasedautophagyinSH-SY5Ycells,asassessedbyelectronmicroscopy,immunofluorescencefortheautophagyproteinLC3/Atg8,LC3electrophoreticmobilityshift,mitochondrialdegradation,andmonodansylcadaverinestainingforlateAVs/autolysosomes.Duringnutrientdeprivat...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期ActivityandSubcellularTraffickingoftheSodium-CoupledCholineTransporterCHTIsRegulatedAcutelybyPeroxynitrite
...HC-3)-sensitivecholinetransporter(CHT)thatprovidessubstrateforacetylcholinesynthesis.Theperoxynitritegenerator3-morpholinosydnonimine(SIN-1)acutelyinhibitedcholineuptakeincellsstablyexpressingFLAG-taggedratCHTinadose-andtime-dependentmanner,withanIC50=0.9±0.14mMandt=4min.SIN-1significantlyred...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期DefectiveFasexpressionexacerbatesneurotoxicityinamodelofParkinson‘sdisease
...orsuperfamily,hasbeenstudiedextensivelyasadeath-inducingreceptorintheimmunesystem.However,Fasisalsowidelyexpressedinanumberofothertissues,includinginneurons.Here,wereportthatdefectsintheFas/FasligandsystemunexpectedlyrendermicehighlysusceptibletoneuraldegenerationinamodelofParkinson‘sdisease.Wefou...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第5期