糖尿病大鼠逼尿肌线粒体超微结构及基质的改变
...EYWORDS:bladder;mitochondrion;diabetes;detrusor 摘要:目的观察2型糖尿病(T2DM)大鼠逼尿肌细胞线粒体超微结构的改变。方法建立T2DM大鼠动物模型,利用透射电镜观察其逼尿肌细胞内线粒体结构并应用BI2000序列图像分析软件检测线粒体密...
医源资料库;在线期刊;现代泌尿外科杂志;2006年第10卷第1期GInterfereswithCa2+-DependentBindingofSynaptotagmintotheSolubleN-Ethylmaleimide-SensitiveFactorAttachmentProteinReceptor(SNARE)Complex
...ofGwiththeternarySNAREcomplexwithfluorescentbinding.PurifiedGwaslabeledwithMIANSenvironmentallysensitivefluorescenceprobe.Thefluorescencechangewasmonitoredbyspectrofluorometryusing20nMlabeledGandvariousconcentrationsofSNAREcomplex.FluorescencechangewasnormalizedbybasalleveloflabeledGfluorescenceandr...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期KnockdownexpressionandhepaticdeficiencyrevealanatheroprotectiveroleforSR-BIinliverandperipheraltissues
...atory,GenomicsDivision,Berkeley,California,USA.AbstractScavengerreceptorSR-BIhasbeenimplicatedinHDL-dependentatheroprotectivemechanisms.WereportthegenerationofanSR-BIconditionalknockoutmousemodelinwhichSR-BIgenetargetingbyloxPsiteinsertionproducedahypomorphicallele(hypomSR-BI).AttenuatedSR-BIexpress...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期当归特征组分的识别与定量对比
...化学物理研究所,辽宁大连116011) 参考文献:[1]LRui-mian,HELi-yi,FANGHong-ju.ActaPharmaceuticaSinica,1980,15:371-374吕瑞绵,何丽一,方洪钜.药学学报,1980,15:371-374[2]LUPei-zhang,ZHANGZi-zhong.JournalofShandongUniversityofTraditionalChineseMedicine,1997,21(...
药品天地;专业药学;实验技术;色谱技术;色谱论文RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages
...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第3期CholesterylEsterTransferProtein(CETP)ExpressionProtectsAgainstDietInducedAtherosclerosisinSR-BIDeficientMice
...ssionofthehumanCETPtransgeneprotectsagainstdiet-inducedatherosclerosisinSR-BIdeficientmice.MethodsandResults-SR-BIdeficient(-/-)micewerecrossedwithCETPtransgenic(CETPtg)micetoproduceacolonyofSR-BI-/-xCETPtgmiceinaC57Bl/6background.Ageandsexmatchedgroupsofgeneticallymodifiedandwild-typeC57Bl/6micewer...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第4期DifferentialAdditiveEffectsofEndothelialLipaseandScavengerReceptor-ClassBTypeIonHigh-DensityLipoproteinMetabolisminKnockoutMouseModels
...crinologyandMetabolism(K.M.,L.C.),DepartmentsofMedicineandMolecularCellularBiology,BaylorCollegeofMedicine,andSt.Luke’sEpiscopalHospital,Houston,Tex;LawrenceBerkeleyNationalLaboratory(T.F.),Berkeley,Calif;andLipoScience(J.D.O.),Raleigh,NC.CorrespondencetoLawrenceChan,DivisionofEndocrinologyMetabol...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期IncreasedOxidativeStressinScavengerReceptorBIKnockoutMiceWithDysfunctionalHDL
【摘要】Objective—InthecurrentstudytheeffectofdisruptionofSR-BI,aprominentregulatorofHDLmetabolism,ontheactivityoftheHDL-associatedantioxidantenzymesPON1andPAF-AHaswellasinvivooxidativestresswereinvestigated.MethodsandResults—SR-BIdeficiencyresultedin1.4-fold(P0.001)and1.6-fold(P0.01...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第11期HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期