TheIL-23/IL-17axisininflammation
...ducesthedifferentiationofnaiveCD4+TcellsintohighlypathogenichelperTcells(Th17/ThIL-17)thatproduceIL-17,IL-17F,IL-6,andTNF-,butnotIFN-andIL-4.TwostudiesinthisissueoftheJCIdemonstratethatblockingIL-23oritsdownstreamfactorsIL-17andIL-6,butnottheIL-12/IFN-pathways,cansignificantlysuppressdiseasedevelopm...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期Interleukin-17FInducesPulmonaryNeutrophiliaandAmplifiesAntigen-inducedAllergicResponse
...ltimoreFoodandDrugAdministration,Rockville,MarylandABSTRACTInterleukin(IL)-17FisarecentlydescribedhumancytokinebelongingtotheIL-17genefamily,butitsinvivofunctionremainstobedetermined.Tothisend,afull-lengthmouseIL-17FcDNAsequencewitha483-bpcodingregionsequencewasfirstidentified.Pulmonarygenetransfero...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第1期宿主抗感染免疫的最新研究成果
...oGenetics公司(现属于施贵宝)的研究人员发表了题为“IL-17REisthefunctionalreceptorforIL-17Candmediatesmucosalimmunitytoinfectionwithintestinalpathogens”的文章,介绍了关于宿主抗感染免疫的最新研究成果,相关论文发表在《NatureImmunology》杂志上...
行业资讯;临床快报;免疫系统Th17细胞的分化调控因素及在自身免疫性疾病中的作用*
【摘要】Th17细胞是在近来受到广泛关注的一类CD4+T细胞亚群,在诸如牛皮癣、类风湿性关节炎、移植排斥等病理过程中发挥着重要的作用。近年来众多研究发现,其在体内外的分化调节受到包括IL-6、IL-21、IL-23、TGF-β和诸如全反...
医源资料库;在线期刊;中华现代临床医学杂志;2012年第10卷第10期DevelopmentalcontrolofCD8+Tcell–aviditymaturationinautoimmunediabetes
...dingreactionandthestructuralrigidityofthereceptors’antigen-bindingsite(9,17).Tcellresponsesusuallyundergoananalogousprocessofaviditymaturation.Althoughthereissomecontroversyastotheunderlyingkineticmechanisms(i.e.,aviditymaturationproceedingthroughoronlyuptocertainaviditythresholds),moststudiesconc...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期Cystine-GlutamateTransporterSLC7A11MediatesResistancetoGeldanamycinbutNotto17-(Allylamino)-17-demethoxygeldanamycin
...tivecorrelationwithgrowthinhibitorypotencyofgeldanamycinbutnotwithitsanalog17-(allylamino)-17-demethoxygeldanamycin(17-AAG),whichdiffersintheC-17substituentinthatthethemethoxymoietyofgeldanamycinisreplacedbyanaminogroup.Structureandpotencyanalysisclassified18geldanamycinanalogsintotwosubgroups,“17...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期Acrucialroleforinterleukin(IL)-1intheinductionofIL-17–producingTcellsthatmediateautoimmuneencephalomyelitis
...,Dublin2,IrelandItwasrecentlydemonstratedthatinterleukin(IL)-23–drivenIL-17–producing(ThIL-17)Tcellsmediateinflammatorypathologyincertainautoimmunediseases.Weshowthattheinductionofantigen-specificThIL-17cells,butnotThelper(Th)1orTh2cells,byimmunizationwithantigensandadjuvantsisabrogatedinIL-1rec...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期InteractionofMAP17withNHERF3/4inducestranslocationoftherenalNa/PiIIatransportertothetrans-Golgi
...ontainingproteinsinteractwithitsCOOHterminuswhilethesmallmembraneproteinMAP17interactswithitsNH2end.ToelucidatethefunctionofMAP17,weidentifieditsinteractingproteinsusingbothbacterialandmammaliantwo-hybridsystems.SeveralPDZdomain-containingproteins,includingthefourNHERFproteins,aswellasNaPiIIaandNHE3...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期访董晨:癌症疫苗曙光乍现
编者按,2005年Th17概念提出,由于其表达的细胞因子和生物学功能、分化过程完全不同于Th1、Th2细胞,且Th17在慢性感染和自体免疫疾病过程中发挥重要的作用,因此,一经发现Th17就引起了研究者们浓厚的兴趣。最近,来自M.DAnder...
医学教育;人物专访Rai1duplicationcausesphysicalandbehavioralphenotypesinamousemodelofdup(17)(p11.2p11.2)
...behavioralphenotypes.Smith-Magenissyndromeisassociatedwitha3.7-Mbdeletionin17p11.2,anditsclinicalpresentationiscausedbyretinoicacidinducible1(RAI1)haploinsufficiency.Thereciprocalmicroduplicationsyndrome,dup(17)(p11.2p11.2),manifestsseveralneurobehavioralabnormalities,buttheresponsibledosage-sensiti...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第11期