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吉利德抗癌药GS-9973II期CLL研究取得强劲缓解率
...实验性、高度选择性、口服有效的磷酸肌醇3-激酶delta（PI3K-delta）抑制剂。PI3K-delta信号对于B淋巴细胞的活化、增殖、生存、迁移（trafficking）至关重要，该信号在多种B细胞恶性肿瘤中过度活动。目前，idelalisib正被开发作为单一...
药品天地；专业药学；药学研究 -
OrphaninFQ/NociceptinPotentiates[D-Ala2,N-Me-Phe4,Gly5-ol]-EnkephalineCInducedeOpioidReceptorPhosphorylation
...hanismsbywhichacuteorphaninFQ/nociceptin(OFQ/N),actingthroughthenociceptinopioidpeptide(NOP)receptor,desensitizesthee?opioidreceptor.WedescribedpreviouslytheinvolvementofproteinkinaseCandG-protein-coupledreceptorkinases(GRK)2and3inOFQ/N-inducede?receptordesensitization.Becausephosphorylationofthee?r...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第2期 -
Phosphatidylinositol-3-KinaseRegulatesScavengerReceptorClassBTypeISubcellularLocalizationandSelectiveLipidUptakeinHepatocytes
...examinedthepossibleregulationofhepaticSR-BIbyphosphatidylinositol-3-kinase(PI3K),awellknownregulatorofendocytosisandmembraneproteintrafficking.MethodsandResults-SR-BI-dependentHDLselectivecholesterolesteruptakeinhumanHepG2hepatomacellswasdecreased(50%)bythePI3KinhibitorswortmanninandLY294002.Insulin...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第9期 -
美欧农药残留检测技术介绍
...。 所有在美国市场上销售的农产品必须满足联邦法典Title40Part180的要求。Part180规定了食品中农药残留的最大允许限量。每次残留限量的修改都在联邦登记公告上，联邦法典可以从以下网站得到：http://www.access.gpo.gov/cgi-bin/cfras...
药品天地；专业药学；实验技术；色谱技术；色谱分析实例 -
人参四物汤对成瘾动物胸腺T细胞亚群增殖及IL-2R的作用研究
...ferationofcellinmorphinedependentmiceandpotentialeffectofChinesemedicineLIUPing,LIBin,WANGShu-Minetal.DepartmentofClinicalPharmacologyof301Hospital,Beijing100853 Abstract Objective:ToobservetheaffectofmorphineonproliferationofcycliccellsandIL-2Rinmice,andeffectofGinsengSiWudecoction.Method:Ku...
合作平台；医学论文；临床医学与专科论文；检验医学 -
Endothelinstimulatesendothelialnitricoxidesynthaseexpressioninthethickascendinglimb
...eNOSexpressionviatheETBreceptorandactivationofphosphatidylinositol3-kinase(PI3K).WehypothesizedthatET-1increaseseNOSexpressionintheTHALbybindingtoETBreceptorsandstimulatingPI3K.InprimaryculturesofmedullaryTHALstreatedfor24h,eNOSexpressionincreasedby36±18%with0.01nMET-1,123±30%with0.1nM...
医源资料库；在线期刊；美国生理学杂志；2004年第287卷第8期 -
ClinicalandMolecularAnalysisofExtended-Spectrum-Lactamase-ProducingEnterobacteriaintheCommunitySetting
...Pharmacie,UniversitedeBordeaux2,Bordeaux,FranceLaboratoiredeBacteriologie,HpitalHaut-Levêque,Pessac,FranceLaboratoiresd‘AnalysesMedicalesduReseauAquitaine,Bordeaux,FranceABSTRACTDuringaprevioussurvey,fiveextended-spectrum-lactamase(ESBL)-producingenterobacteria(ESBLE)(twoEnterobacteraerogenesisol...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第10期 -
RegulationofVascularEndothelialGrowthFactorExpressionandVascularizationintheMyocardiumbyInsulinReceptorandPI3K/AktPathwaysinInsulinResista
...owthfactor(IGF)-1increasedVEGFmRNAandproteinexpressionby2-fold.InhibitionofPI3K/Akt,especiallyAkt2-mediatedcascadesbutnottheRas/MEK/Erkpathway,usingchemicalinhibitors,dominantnegativeadenoviralconstructs,orsiRNAapproachessuppressedVEGFmRNAexpressionbyinsulin.Ventriculartissuesfrommuscleinsulinrecept...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第4期 -
弥漫性颅内压升高TCD频谱和参数的变化
...anialhypertensionLIQing，ZHAOJing-tao，ZENGQun，etal. TheCentralHospitalofXiangtanCity，Hunan411100，China 【Abstract】ObjectiveToobservethechangesoftranscranialDopplerflowpatternsandparametersindiffusein-tracranialhypertension.Methods66patientswithintracranialhypertensioncausedbydi...
医源资料库；在线期刊；中华医学研究杂志；2005年第5卷第9期 -
Down-RegulationofUbiquitinLigaseCblInducedbyTwistHaploinsufficiencyinSaethre-ChotzenSyndromeResultsinIncreasedPIK/AktSignalingandOsteoblast
...tedwithdecreasedubiquitin-mediateddegradationofphosphatidylinositol3kinase(PI3K)andincreasedPI3KexpressionandPI3K/Aktsignaling.IncreasedPI3KimmunoreactivitywasalsofoundinosteoblastsinhistologicalsectionsofaffectedcranialsuturesfromSCSpatients.TransfectionwithTwistorCblabolishedtheincreasedPI3K/Aktsi...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第10期