TheBRAF–MAPKsignalingpathwayisessentialforcancer-immuneevasioninhumanmelanomacells
...ymelanomacellswiththemutationofBRAF,whichencodesaMAPKKs,(BRAFV600E).MEKinhibitorU0126orRNAinterference(RNAi)forBRAFV600Edecreasedproductionoftheimmunosuppressivesolublefactorsinterleukin(IL)-10,VEGF,orIL-6frommelanomacellstolevelscomparabletothoseaftersignaltransducerandactivatoroftranscription(STAT...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期AmolecularchaperoneformitochondrialcomplexIassemblyismutatedinaprogressiveencephalopathy
...tmentofHumanGenetics,McGillUniversity,Montreal,Quebec,Canada.AbstractNADH:ubiquinoneoxidoreductase(complexI)deficiencyisacommoncauseofmitochondrialoxidativephosphorylationdisease.Itisassociatedwithawiderangeofclinicalphenotypesininfants,includingLeighsyndrome,cardiomyopathy,andencephalomyopathy.Inat...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期ValidationofapXO2-APCRAssayToExploreDiversityamongItalianIsolatesofBacillusanthracisStrainsCloselyRelatedtotheLive,AttenuatedCarbosapVa
...bertandemrepeatanalysis.Wedescribeheretheuseofaninthlocusabletoexplorevariabilityamongstrainsthathavethesamegenotype.ItisimportanttobeabletogenotypethewildisolateofB.anthracisstrainsfromoutbreaksofanthraxinareaswhereCarbosapvaccinationofcattleandsheepiscommonpractice.Atotalof27representativefieldstr...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期StimulationofLiver-DirectedCholesterolFluxinMicebyNovelN-Acetylgalactosamine-TerminatedGlycolipidsWithHighAffinityfortheAsialoglycoproteinRec
...olesterolfluxcansuppressatherosclerosis,asdemonstratedforscavengerreceptor-BIoverexpressioninhypercholesterolemicmice.Inanalogy,wespeculatethatincreasinglipoproteinfluxtotheliverviatheasialoglycoproteinreceptor(ASGPr)maybeoftherapeuticvalueinhypercholesterolemia.MethodsandResults-Abifunctionalglycol...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期Schitz与Goldmann眼压计对眼压测量的比较研究
【摘要】+2.0D或<-2.0D,眼压>30mmHg;应用Goldmann眼压计进行眼压测量,5min后应用Schitz眼压计进行眼压测量。结果Schitz眼压计与Goldmann眼压计测量的眼压平均值分别为(16.88±4.17)mmHg和(16.97±4.15)mmHg,ST与GT测量值中位数...
医源资料库;在线期刊;滨州医学院学报;2008年第31卷第3期一种评价中药色谱指纹谱相似性的新方法:向量夹角法
...YBETWEENTWOCHROMATOGRAPHICFINGERPRINTSOFCHINESEHERBWANGLong-xing1,XIAOHong-bin1,LIANGXin-miao1,BIKai-shun2(1DalianInstituteofChemicalPhysics,ChineseAcademyofSciences,Dalian116012,China2ShenyangPharmaceuticalUniversity,Shenyang110015,China)ABSTRACT:AIMToCalculatethesimilaritybetweentwochromatographic...
药品天地;专业药学;中药大全;中药指纹图谱Dlgh1coordinatesactinpolymerization,synapticTcellreceptorandlipidraftaggregation,andeffectorfunctioninTcells
1DepartmentofMicrobiology,Immunology,andMolecularGenetics2MolecularBiologyInstitute,UniversityofCalifornia,LosAngeles,LosAngeles,CA900953LaJollaInstituteforAllergyandImmunology,SanDiego,CA92121Lipidraftmembranecompartmentalizationandmembrane-associatedguanylatekinase(MAGUK)familymolecularscaffoldsfu...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期SelectivedysregulationoftheFcIIBreceptoronmemoryBcellsinSLE
1DepartmentofMedicine,ColumbiaUniversityMedicalCenter,NewYork,NY100322DepartmentofMedicine,AlbertEinsteinCollegeofMedicine,Bronx,NY104613MacroGenicsInc.,Rockville,MD208504TheRockefellerUniversity,NewYork,NY10021TheinappropriateexpansionandactivationofautoreactivememoryBcellsandplasmablastscontribute...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第9期Staphylococcusaureusgoldenpigmentimpairsneutrophilkillingandpromotesvirulencethroughitsantioxidantactivity
...omparedwiththewild-type(WT)bacterium,aS.aureusmutantwithdisruptedcarotenoidbiosynthesisismoresusceptibletooxidantkilling,hasimpairedneutrophilsurvival,andislesspathogenicinamousesubcutaneousabscessmodel.ThesurvivaladvantageofWTS.aureusoverthecarotenoid-deficientmutantislostuponinhibitionofneutrophil...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第2期Long-TermMolecularAnalysisofTuberculosisStrainsinAlabama,aStateCharacterizedbyaLargelyIndigenous,Low-RiskPopulation
DivisionofPulmonaryandCriticalCareMedicineDepartmentofMicrobiologyDepartmentofPathologyDivisionofGeneralInternalMedicineDepartmentofEpidemiology,UniversityofAlabamaatBirminghamAlabamaDepartmentofPublicHealth,Montgomery,AlabamaABSTRACTWithatuberculosiscasedetectionrateof5.9per100,000populationin2001,...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期