ImpaireddegranulationbutenhancedcytokineproductionafterFcRIstimulationofdiacylglycerolkinase–deficientmastcells
...activatedproteinkinase;PA,phosphatidicacid;PCA,passivecutaneousanaphylaxis;PI5K,phosphatidylinositol4-phosphate5-kinase;PIP2,phosphatidylinositol4,5-bisphosphate;PKC,proteinkinaseC;PLC,phospholipaseC.B.A.OlenchockandR.Guocontributedequallytothiswork.Mastcellsplayimportantrolesinbothinnateandadaptive...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第6期CorrelationbetweenhyperphosphatemiaandtypeIINa-Picotransporteractivityinklothomice
...phatehomeostasis.ThegoalofthepresentstudywastoinvestigatetheregulationofNa-Picotransportersinklothomutant(kl/kl)mice.Thekl/klmicedisplayedhyperphosphatemia,highplasma1,25(OH)2D3levels,increasedactivityoftherenalandintestinalsodium-dependentPicotransporters,andincreasedlevelsofthetypeIIa,typeIIb,andt...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期数字化医学影像重建的处理程序
...werspectrumcanbeapproximatedasaconstant.Pn(ω)≈A(constant).Thetypicalformofthepowerspectrumisapproximationas:Pf(ω)=Be-αω (11)Bandaareallconstants.TheimprovedWienerfiltertransferfunctioncanbewrittenas:Meω(ω)=H*(ω)|H(ω)|2+Ceαω...
医源资料库;在线期刊;中华医学研究杂志;2007年第7卷第8期Intermittentpressureoverloadtriggershypertrophy-independentcardiacdysfunctionandvascularrarefaction
...dtherolesofdurationandnatureofthestressonthedevelopmentofcardiacfailure.Despiteamildhypertrophicresponse,preservedsystolicfunction,andafavorablefetalgeneexpressionprofile,heartsexposedtointermittentpressureoverloaddisplayedpathologicalfeatures.Importantly,intermittentpressureoverloadcauseddiastolicd...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期聚丙烯粉料中挥发性组分的项空气相色谱法测定
...得的挥发性组分i的峰面积Ai与组分i在顶空中的蒸气分压Pi成正比。Ai∝Pi (1) 写成方程式,则为:Ai=Si×Pi (2)式中 Si——单位i物质量在所用检测器上的特定响应值 组分i的蒸气压通常表达为:AiPi=P0i×Xi×Ri (3)...
药品天地;专业药学;实验技术;色谱技术;色谱论文Whole-bodyskeletalmusclemass:developmentandvalidationoftotal-bodypotassiumpredictionmodels
ZiMianWang,ShankuanZhu,JackWang,RichardNPierson,JrandStevenBHeymsfield1FromtheObesityResearchCenter,StLukes-RooseveltHospital,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork.2SupportedbyNationalInstitutesofHealthgrantPO1-DK42618.3Reprintsnotavailable.AddresscorrespondencetoZMWang,Weig...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第1期聚丙烯粉料中挥发性组分的项空气相色谱法测定
...得的挥发性组分i的峰面积Ai与组分i在顶空中的蒸气分压Pi成正比。Ai∝Pi (1) 写成方程式,则为:Ai=Si×Pi (2)式中 Si——单位i物质量在所用检测器上的特定响应值 组分i的蒸气压通常表达为:AiPi=P0i×Xi×Ri (3)...
药品天地;专业药学;实验技术;色谱技术;色谱分析实例三、SH-2结构域的调节作用
...如IP2特异的PLC、磷脂酰肌醇3激酶(phosphatidylinositol3kinase,PI-3K)的调节亚单位(P85),调节ras活性的ras-GTP酶激活蛋白(GTPaseactivatingprotein,GAP)以及crk、abl和vav原癌基因产物等。图8-8参与T细胞活化并含SH-2、SH-3结构域分子的模式图...
医源资料库;医源图书馆;教材类;细胞和分子免疫学Insulin-LikeGrowthFactor-IRegulatesProliferationandOsteoblasticDifferentiationofCalcifyingVascularCellsviaExtracellularSignal-RegulatedProtein
...acellularsignal-regulatedproteinkinase(ERK)andphosphatidylinositol3-kinase(PI3K)pathways.InhibitionofeithertheERKorPI3KpathwayreversedIGF-IeffectsonCVCproliferationandAPactivity,suggestingacommondownstreamtarget.OverexpressionofERKactivatoralsomimickedIGF-Iinhibitionoflipopolysaccharide-inducedAPact...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第3期Toll-LikeReceptor4–Dependentand–IndependentCytokineSecretionInducedbyMinimallyOxidizedLow-DensityLipoproteininMacrophages
...pressinghuman15-lipoxygenase.MmLDLstimulatedrobustphosphoinositide3-kinase(PI3K)activation,andAktandextracellularsignal-regulatedkinase1/2(ERK1/2)phosphorylation,whichexceededthatinducedbyLPS.Ontheotherhand,althoughmmLDLinducednuclearfactorB(NF-B)p65translocationtothenucleus,therewasnodetectableNF-B...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第6期