IdentificationofHypertension-RelatedGenesThroughanIntegratedGenomic-TranscriptomicApproach
...ofSBH/yandSBN/yratsthathadbeenfedregulardietorsalt-loaded.WeusedtheAffymetrixRatGenomeRAE230GeneChipandprobed30000transcripts.Theresearchalgorithmcalledforaninitialgenome-widescreenfordifferentiallyexpressedtranscriptsbetweenthestudygroups.Thisstepwasfollowedbyclusteranalysisbasedon2x2ANOVAtoidentif...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第4期Thealchemyoftendonrepair:aprimerforthe(S)madscientist
...ndetome,demarcatedattheearlieststagesofdevelopmentbyexpressionofthebasichelix-loop-helixtranscriptionfactorgeneScleraxis.Inadditiontopromotingtenocyte“birth,“themyoprogenitorsofthemyotomeappeartopreventchondrogenicdifferentiationoftenocyteprogenitors.Theparacrinesignalsthatfine-tunemultipotentme...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期神经肽Y与妊娠高血压综合征
...皮功能紊乱,缩血管物质增加,舒血管物质释放减少,促凝血因子生成增加,抗凝血因子生成减少,血管通透性增加,出现妊高征的病理生理表现。随着妊高征病情的加重,NPY的水平逐渐升高。ON-UOHA[8]研究显示,在全身小动...
医源资料库;在线期刊;齐鲁医学杂志;2006年第21卷第4期Species-SpecificFibroblastsRequiredforTriggeringInvasivenessofPartiallyTransformedOralKeratinocytes
...asion:Dinv,Ainv)andimmunohistochemistry.PresenceofhumanfibroblastsinthematrixinducedalocalinvasionofDOK(Dinv=95.6??7.1µm,Ainv=45.8??3.5%).Minimalinvasion(P<0.05)wasobservedwhenDOKgrewonsimplecollagenmatrix(Dinv=14.1??2.1µm,Ainv=3.7??0.8%)ormatricescontainingfibroblastsfrommouse(Dinv=11.5...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第6期Caffeydisease:anunlikelycollagenopathy
...inperiosteum,ligaments,dermis,andtendon.Itismadeofalong,continuoustriplehelixthatassemblesinhighlyorganizedcollagenfibrils.Thefibrilshavehightensilestrength,whichiscriticalforthefunctionofboneandothertissues(7).Glycineoccursateverythirdresidueofthetriple-helicaldomain.Becauseofitssmallsize,itpacksti...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期AntithromboticEffectofaProtein-TypeIClassSnakeVenomMetalloproteinase,Kistomin,IsMediatedbyAffectingGlycoproteinIb-vonWillebrandFactorIntera
...ntithromboticBindingofvonWillebrandfactor(vWF)toplateletglycoprotein(GP)Ib-IX-Vmediatesplateletactivationintheearlystageofthrombusformation.Kistomin,asnakevenommetalloproteinase(SVMP)purifiedfromvenomofCalloselasmarhodostoma,hasbeenshowntoinhibitvWF-inducedplateletaggregation.However,itsactionmechan...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期凝血功能异常在老年缺血性脑血管病的临床意义
【摘要】 目的探讨凝血功能异常在老年缺血性脑血管病中的临床意义。方法测定老年缺血性脑血管病患者血浆纤维蛋白原(Fbg)、D-二聚体(D-Dimer,DD)、抗凝血酶-Ⅲ抗原(AT-Ⅲ:Ag)和抗凝血酶-III活性(AT-Ⅲ:C)的水平...
医源资料库;在线期刊;中国热带医学杂志;2007年第7卷第8期凝血酶致大鼠脑出血后脑水肿的研究
【摘要】目的探讨凝血酶与大鼠脑出血后脑水肿的关系。方法以SD大鼠为研究对象,随机将大鼠分为生理盐水组、脑出血组、凝血酶组。以自体血、凝血酶注入大鼠尾状核,建立脑出血模型,采用干湿重法观察脑水肿情况。每组...
合作平台;在线期刊;中华实用医药杂志;2005年第5卷第7期;论著Whatisknownaboutthesafetyofmultivitamin-multimineralsupplementsforthegenerallyhealthypopulation?Theoreticalbasisforharm
...tisconsumedinaconcentratedform,thatis,asasupplement,orwithinanormalfoodmatrix.Large,singledosesofmanynutrientscanresultingastrointestinaleffects,forexample,vitaminCinlargedosesisassociatedwithdiarrhea,asismagnesium,whereasironisgenerallyassociatedwithconstipationbutalsowithnausea,vomiting,andepigast...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第1期止血及凝血障碍的检查
【关键词】止血凝血障碍检查人体血液中存在着止血系统、抗凝血系统及纤溶系统,三者互相对立统一,保持平衡,人们才能保持正常生活。1血小板的生成及结构和功能1.1血小板生成血小板由骨髓巨核细胞系统,由产板型巨核...
医源资料库;在线期刊;中华中西医杂志;2009年第10卷第5期