Urokinase-TypePlasminogenActivator,anEndogenousAntibiotic
...namurineinfectionmodel,uPAtreatmentalleviatedstaphylococcalsepsisbyinhibitingbacterialgrowth.TofurtherevaluatethechangesinuPAlevelsduringthecourseofstaphylococcalinfection,totaluPAandactiveuPAlevelswereanalyzedinplasmaandinkidneyhomogenates.ExpressionoftotaluPAwasconstant,butPAI-1levelsweredramatica...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第15期HumanScalpHairFolliclesAreBothaTargetandaSourceofProlactinwhichServesasanAutocrineand/orParacrinePromoterofApoptosis-DrivenHairFollicl
...yofbioregulatoryeffectsinmammalsandisalsofoundinextrapituitarysites,includingmurineskin.Here,weshowbyreversetranscriptase-polymerasechainreactionandimmunohistologythat,contrarytoapreviousreport,humanskinandnormalhumanscalphairfollicles(HFs),inparticular,expressbothPRLandPRLreceptors(PRL-R)atthemRNAa...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第3期ControlleddeliveryofPDGF-BBformyocardialprotectionusinginjectableself-assemblingpeptidenanofibers
...thatprotectionofcardiomyocytesbyendothelialcellsoccursthroughPDGF-BBsignaling.PDGF-BBinducedcardiomyocyteAktphosphorylationinatime-anddose-dependentmannerandpreventedapoptosisviaPI3K/Aktsignaling.Usinginjectableself-assemblingpeptidenanofibers,whichboundPDGF-BBinvitro,sustaineddeliveryofPDGF-BBtothe...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第1期Hypogonadism,QuadricepsWeakness,andExerciseIntoleranceinChronicObstructivePulmonaryDisease
...cine,KatholiekeUniversiteitLeuven,Leuven,BelgiumABSTRACTRationale:Circulatinglevelsoftestosteroneandgonadotrophinsofpatientswithchronicobstructivepulmonarydisease(COPD)haveneverbeencomparedwiththoseofelderlymenwithnormalpulmonaryfunction.Moreover,therelationshipofhypogonadismwithquadricepsmuscleweak...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第11期Cyclooxygenases,microsomalprostaglandinEsynthase-1,andcardiovascularfunction
...sylvania,USA.2DepartmentsofPhysiologyandBiochemistry,Queen’sUniversity,Kingston,Ontario,Canada.AbstractWeinvestigatedthemechanismsbywhichinhibitorsofprostaglandinG/Hsynthase-2(PGHS-2;knowncolloquiallyasCOX-2)increasetheincidenceofmyocardialinfarctionandstroke.Theseinhibitorsarebelievedtoexertbotht...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期高效液相色谱法测定血浆中氟哌啶醇浓度
...248nm处检测。结果:血浆中氟哌啶醇的最低检测浓度为0.5ng/ml,平均提取回收率为86.6%±4.9%,线性范围1~50ng/ml(r=0.9998),日内和日间RSD分别小于8%和9%。结论:方法灵敏、快速、准确,可满足临床治疗药物的监测工作。关键词 氟哌啶...
药品天地;专业药学;实验技术;色谱技术;色谱论文Controloftightjunctionalsealing:roleofepidermalgrowthfactor
...tophysiologicalrequirements,pathologicalconditions,andpharmacologicalchallenges.Thisisreflectedbyatransepithelialelectricalresistance(TER)rangingfromafewtenthtoseveralthousands·cm2,dependingonthedegreeofsealingofthetightjunction(TJ).Thepresentworkispartofanefforttounderstandthecausesandmechan...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期Identificationofeosinophillineage–committedprogenitorsinthemurinebonemarrow
...rogenitors(GMPs)gaverisetoeosinophilsaswellasneutrophilsandmonocytesatthesinglecelllevel.Withintheshort-termcultureofGMPs,theeosinophilpotentialwasfoundexclusivelyincellsactivatingthetransgenicreporterforGATA-1,atranscriptionfactorcapableofinstructingeosinophillineagecommitment.TheseGATA-1–activat...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第12期粒细胞集落刺激因子调节Th1Th2的体外实验研究
...因子的表达及Th1/Th2细胞表面AnnexinV的表达。结果G-CSF(100ng/ml)作用于PBMC后,CD4+细胞IL-4表达明显增高,IFN-γ表达下降;Th1和Th2细胞表面AnnexinV的表达差异无显著性。结论G-CSF能够调节Th1/Th2之间的平衡,使Th1向Th2转化,这可能在外...
合作平台;在线期刊;中华中西医杂志;2004年第5卷第1期;论著生长抑素与肿瘤血管关系的研究
...织和血液所释放的肽酶迅速灭活,半衰期短,只有3min,因而临床受很大的限制,因此人们在确定了其功能基团结构的基础上,系统地设计并合成了多种生长抑素类似物,探索和使用的有6肽、7肽、8肽和14肽等多个系列。具有代表...
医源资料库;在线期刊;中华现代内科学杂志;2006年第3卷第2期