医学属性特征敏感性问题的调查设计与分析
... Thedesignandanalysisonqualitativesensitiveproblem WangChunping,GuoJizhi,ZhaiQiang WeifangMedicalCollege,Shandong261041. 【Abstract】ObjectiveToresearchthedesignandanalysisonqualitativesensitiveproblem.MethodsAim-ingatdifferenttypesofqualitativesensitiveproblem,th...
合作平台;在线期刊;中华医学研究杂志;2004年第4卷第12期;论著1-HydroxylasegeneablationandPisupplementationinhibitrenalcalcificationinmicehomozygousforthedisruptedNpt2agene
【摘要】DisruptionofthemajorrenalNa-phosphate(Pi)cotransportergeneNpt2ainmiceleadstoasubstantialdecreaseinrenalbrush-bordermembraneNa-Picotransport,hypophosphatemia,andappropriateadaptiveincreasesinrenal25-hydroxyvitaminD3-1-hydroxylase(1OHase)activityandtheserumconcentrationof1,25-dihydroxyvita...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期生化所引进PI最新文章解析离子通道
来自中国科学院上海生命科学研究院生物化学与细胞生物学研究所的研究人员发现炎性因子前列腺素E2通过调节Nav1.8的细胞内转运来增加该通道在细胞膜上的表达量,从而增强该通道的功能,这一发现丰富了离子通道转运的基本...
行业资讯;临床快报;细胞分子与蛋白质组TransactivationoftheIGF-1Rbyaldosterone
【摘要】Activationofepithelialsodiumchannels(ENaC)byaldosterone,insulin,orinsulin-likegrowthfactor-1(IGF-1)inrenalepithelialcells(includingtheXenopuslaevisrenalcelllineA6)appearstosharesomecommonsignalingelementssubsequenttotheinitialinsulinorIGF-1receptoractivation.Previously,theconvergencepoin...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第4期FarnesoidXreceptorisessentialfornormalglucosehomeostasis
...acidreceptorfarnesoidXreceptor(FXR;NR1H4)isacentralregulatorofbileacidandlipidmetabolism.WeshowherethatFXRplaysakeyregulatoryroleinglucosehomeostasis.FXR-nullmicedevelopedseverefattyliverandelevatedcirculatingFFAs,whichwasassociatedwithelevatedserumglucoseandimpairedglucoseandinsulintolerance.Theiri...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第4期第三节 ATP的生成、储存和利用
...酸化合物,当ATP水解时首先将其分子的一部分,如磷酸(Pi)或腺苷酸(AMP)转移给作用物,或与催化反应的酶形成共价结合的中间产物,以提高作用物或酶的自由能,最终被转移的AMP或Pi将被取代而放出,ATP多以这种通过磷酸基团等...
医源资料库;医源图书馆;教材类;生物化学与分子生物学VascularEndothelialGrowthFactorActivatesPI3K/Akt/ForkheadSignalinginEndothelialCells
...s.Inthisstudy,weexaminedwhetherVEGFiscoupledtophosphatidylinositol3-kinase(PI3K)/Akt/forkheadinECs.MethodsandResults—WedemonstratethathumanECsexpressmembersoftheforkheadfamily(FKHR,FKHRL1,andAFX)andthatVEGFmodulatesthephosphorylation,subcellularlocalization,andtranscriptionalactivityofoneormoreoft...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第2期PostprandialresponsetoaphysiologiccaloricloadinHIV-positivepatientsreceivingproteaseinhibitorbasedornonnucleosidereversetranscriptasein
...ooseveltMedicalCenter,DivisionofInfectiousDisease(SR,RM,andWME-S),HarlemHospitalCenterandColumbiaUniversity,NewYork,NY;theDepartmentofMedicine,UniversityofCaliforniaDavis,Davis,CA(BOandLB);andtheVANorthernCaliforniaHealthCareSystem(LB)2Supportedbygrants65938(principalinvestigator:LB)and65954(princip...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第1期TrainingandcertifyingPhysicianNutritionSpecialists:theAmericanBoardofPhysicianNutritionSpecialists(ABPNS)
...ghtstothetermPhysicianNutritionSpecialist,sothatonlyitsdiplomatesmayusethistitle.PARADIGMFORPHYSICIANNUTRITIONSPECIALISTSIPNECdevelopedandpromulgatedthefollowingparadigmforPNSstoencouragegrowthinthenumberofnutritiontrainingprogramsandinthenumberofphysicianswhopursuenutritiontraining.APNSisaphysician...
医源资料库;在线期刊;美国临床营养学杂志;2006年83卷第4期吉利德抗癌药GS-9973II期CLL研究取得强劲缓解率
...实验性、高度选择性、口服有效的磷酸肌醇3-激酶delta(PI3K-delta)抑制剂。PI3K-delta信号对于B淋巴细胞的活化、增殖、生存、迁移(trafficking)至关重要,该信号在多种B细胞恶性肿瘤中过度活动。目前,idelalisib正被开发作为单一...
药品天地;专业药学;药学研究