18Years’experiencewithhighdoseratestrontium-90brachytherapyofsmalltomediumsizedposterioruvealmelanoma
...fsmalltomediumsizedchoroidalmelanoma(CM)withahighdoserate(HDR)strontium-90(Sr-90)applicator.Methods:From1983until2000,98eyeswithCMweretreatedwithSr-90brachytherapy.Themainoutcomemeasureswereactuarialratesofthepatients’survival,ocularconservationrate,tumourregression,complicationrates,andpreservati...
医源资料库;在线期刊;英国眼科学杂志;2005年第89卷第10期Ligand-DirectedSignalingatthe3-AdrenoceptorProducedby3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanoloxalate(SR59230A)Re
...MPaccumulationandECARinCHO3HandCHO3Lcells.ForcAMPaccumulation,the3-ARligandSR59230AwasapartialagonistinCHO3HandanantagonistinCHO3LcellsbutforECARwasanagonistatbothexpressionlevels.ThissuggestedthatSR59230A,whichisnormallyregardedasanantagonist,canselectivelyactivatepathwaysleadingtoECAR.Examinationo...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第11期美研究人员发现维甲酸相关孤核受体激动剂
...物对于RORαandRORγ的效应。研究人员发现其中一个化合物SR1078具有非常显著的效应。“SR1078显示了独特的药理特征表明它具有较高的潜力作为一种化学标记检测ROR受体功能。此外,我们还意外地发现SR1078具有ROR激活剂的效应,”Bu...
行业资讯;临床快报;免疫系统武汉大学Cell文章揭示转录的奥秘
...学、加州大学圣地亚哥分校的研究人员在新研究中证实,SR蛋白与7SK和启动子相关新生(Nascent)RNA协同作用,促进了转录过程中停顿的聚合酶释放。这一研究发现为阐明真核基因中的转录调控机制,深入了解相关疾病提供了重要...
医药经济;生物技术;技术要闻南京古生物所埃迪卡拉纪古海洋环境变化研究获进展
...负漂移(最低值达到−26.7‰,VPDB),锶同位素比值(87Sr/86Sr)也发生了显著的升高。王伟等将极低的氧同位素值解释为冰川融水的信号,表明碳酸盐岩沉积于冰川融水(或与海水的混合水体)环境,从而证实该时期发生了冰...
医药经济;生物技术;技术要闻免试剂离子色谱测定阳离子中的离子抑制器应用研究
...淋洗液发生器,Chromeleon色谱工作站,DS-5型电导检测器,CSRS-I(4mm)抑制器,色谱柱为IonPacCG16保护柱(3mm×50mm)。2.2实验条件淋洗液:采用RFC产生的高纯甲基磺酸溶液(18mmol/L);流速:0.55mL/min;自动再生抑制电流根据实验要求所...
药品天地;专业药学;实验技术;色谱技术;色谱入门Low-DensityLipoproteinFromApolipoproteinE-DeficientMiceInducesMacrophageLipidAccumulationinaCD36andScavengerReceptorClassA-DependentManner
...dfoamcellformation.ExperimentsusingMPMslackingCD36,scavengerreceptorclassA(SR-A),orboth,indicatedamajorcontributionofCD36(50%),andtoalesserextent,SR-A(24%to30%),toE–/–LDLuptake.Conclusions—Becauseofitsincreasedstateofoxidationandhighcholesterolcontent,LDLinapoE-deficientmiceactsinaproatherogen...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期SphingosineandItsAnalog,theImmunosuppressant2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol,InteractwiththeCB1CannabinoidReceptor
...hlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide([3H]SR141716A)andthecannabinoidagonist[3H](-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol([3H]CP55,940)inaconcentration-dependentmannerinbothCB1-expressingcelllinesandmousecerebellum.Howev...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期DrugResistanceandFitnessinMycobacteriumtuberculosisInfection
...ersusdrug-susceptiblestrains,tocalculatetherelativesecondarycase-rateratio(SR).Theyconcludedthat,inthecontextofaneffectivetuberculosiscontrolprogram,strainsthatwereresistanttoisoniazideitheraloneorincombinationwithotherdrugswerelesslikelytoresultinsecondarycasesthanweredrug-susceptiblestrains.Howeve...
医源资料库;在线期刊;传染病学杂志;2005年第191卷第5期CXCL16/SR-PSOXIsanInterferon-–RegulatedChemokineandScavengerReceptorExpressedinAtheroscleroticLesions
...ndguidesmigrationofactivatedTh1andTc1cells.ItisidenticaltoscavengerreceptorSR-PSOX,whichmediatesuptakeofoxidizedlow-densitylipoprotein.WeinvestigatedwhetherCXCL16expressioniscontrolledbyinterferon-(IFN-)-cytokineabundantinatheroscleroticlesions.MethodsandResults—CXCL16andCXCR6expressionwasidentifi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第4期