Twistingtailsexposed:theevidenceforTCRconformationalchange
...cturalstudiesargueagainstaconformationalchange,recentstudiessupportthepossibilityforsuchachangewithintheCD3componentsoftheTCRcomplex.Inthiscommentary,theevidenceforTCRconformationalchangeisreviewedandpotentialmechanismsforitsinitiationareexplored.AlthoughagreatdealisknownaboutthedetailsofTCRsignalin...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期SuspensionMicroarraywithDendrimerSignalAmplificationAllowsDirectandHigh-ThroughputSubtypingofListeriamonocytogenesfromGenomicDNA
...naryMedicine,WashingtonStateUniversity,Pullman,Washington99164USDA-ARSMicrobialGenomicsandBioprocessingResearchUnit,Peoria,Illinois61604Genisphere,Inc.,Hatfield,Pennsylvania19440ABSTRACTListeriamonocytogenesisasignificantcauseoffood-bornediseaseandmortality;therefore,epidemiologicalinvestigationsoft...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期Organ-specificrolesfortranscriptionfactorNF-Binreovirus-inducedapoptosisanddisease
...tofPediatrics,2ElizabethB.LambCenterforPediatricResearch,3DepartmentofMicrobiologyandImmunology,4DepartmentofPathology,5DepartmentofSurgery,and6DepartmentofMedicine,VanderbiltUniversitySchoolofMedicine,Nashville,Tennessee,USA.7DepartmentofMolecularBiomedicalSciences,NorthCarolinaStateUniversity,Rale...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期ImprovingTrialPowerThroughUseofPrognosis-AdjustedEndPoints
...(F.B.Y.,K.R.L.),GardinerInstitute,WesternInfirmary,andtheRobertsonCentreforBiostatistics(C.J.W.),BoydOrrBuilding,UniversityofGlasgow,UniversityAvenue,UK.AbstractBackgroundandPurpose—Thestrokepatientpopulationisheterogeneous,leadingtowidevariationinoutcomecausedbydifferencesinage,initialseverity,an...
医源资料库;在线期刊;中风学杂志;2005年第36卷第3期NaturalKillerCellInhibitoryReceptorsBlockActinCytoskeleton-dependentRecruitmentof2B4(CD244)toLipidRafts
...ler(NK)cellsuponengagementofavarietyofdifferentactivationreceptorsandofinhibitoryreceptorsthatrecruitthetyrosinephosphataseSHP-1.However,thestepatwhichactivationsignalsareblockedbySHP-1isnotknown.Wehavebeenusingactivationreceptor2B4(CD244)tostudytheinfluenceofinhibitoryreceptorsonNKcellactivation.En...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第1期NaturalKillerCellInhibitoryReceptorsBlockActinCytoskeleton-dependentRecruitmentof2B4(CD244)toLipidRafts
...ler(NK)cellsuponengagementofavarietyofdifferentactivationreceptorsandofinhibitoryreceptorsthatrecruitthetyrosinephosphataseSHP-1.However,thestepatwhichactivationsignalsareblockedbySHP-1isnotknown.Wehavebeenusingactivationreceptor2B4(CD244)tostudytheinfluenceofinhibitoryreceptorsonNKcellactivation.En...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第1期RegulatoryTcellsinhibitstablecontactsbetweenCD4+Tcellsanddendriticcellsinvivo
1MolecularPathogenesisProgram,SkirballInstituteofBiomolecularMedicine,2DepartmentofPathology,NewYorkUniversitySchoolofMedicine,NewYork,NY10016RegulatoryT(Treg)cellsexertpowerfuldown-modulatoryeffectsonimmuneresponses,butitisnotknownhowtheyactinvivo.Usingintravitaltwo-photonlaserscanningmicroscopywed...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期HDLfromCETP-deficientsubjectsshowsenhancedabilitytopromotecholesteroleffluxfrommacrophagesinanapoE-andABCG1-dependentpathway
1DivisionofMolecularMedicine,DepartmentofMedicine,ColumbiaUniversity,NewYork,NewYork,USA.2DepartmentofAnatomyandCellBiologyandScientificComputingCenter,StateUniversityofNewYork,DownstateMedicalCenter,NewYork,NewYork,USA.AbstractGeneticdeficiencyorinhibitionofcholesterylestertransferprotein(CETP)lead...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期Neutrophilsfromp40phox–/–miceexhibitseveredefectsinNADPHoxidaseregulationandoxidant-dependentbacterialkilling
...edinucleotidephosphate(NADPH)oxidasecomplexplaysacriticalroleintheantimicrobialfunctionsofthephagocyticcellsoftheimmunesystem.Thecatalyticcoreofthisoxidaseconsistsofacomplexbetweengp91phox,p22phox,p47phox,p67phox,p40phox,andrac-2.Mutationsineachofthephoxcomponents,exceptp40phox,havebeendescribedinca...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期