DifferentialRolesofPhosphoinositide-DependentProteinKinase-1andAkt1ExpressionandPhosphorylationinBreastCancerCellResistancetoPaclitaxel,Doxo
...DK1)andAkt1aretwocloselyrelatedcomponentsofthephosphatidylinositol-3kinase(PI3K)pathway,whichisaberrantlyregulatedinbreastcancer.DespitetheimportanceofPDK1,fewstudieshaveevaluateditasapotentialtargetforcancertherapycomparedwithstudiesofAkt1.WehypothesizedthatPDK1isasuperiortargetinthePI3Kpathway.Tot...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期FASL–844Cpolymorphismisassociatedwithincreasedactivation-inducedTcelldeathandriskofcervicalcancer
1DepartmentofEtiologyandCarcinogenesis,CancerInstituteandHospital2DepartmentofGynecologicOncology,CancerInstituteandHospital3DepartmentofMedicalOncology,CancerInstituteandHospital4DepartmentofEpidemiology,InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Bei...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期CardiacSarcoplasmicReticulumCalciumReleaseandLoadAreEnhancedbySubcellularcAMPElevationsinPI3K-DeficientMice
...,Austria.AbstractWerecentlyshowedthatphosphoinositide-3-kinase-eCdeficient(PI3KeC/eC)micehaveincreasedcardiaccontractilitywithoutchangesinheartsizecomparedwithcontrolmice(ie,PI3K+/+orPI3K+/eC).Inthisstudy,weshowthatPI3KeC/eCcardiomyocyteshaveelevatedCa2+transientamplitudeswithabbreviateddecaykinetic...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第5期SubstrateinteractionsinthehumantypeIIasodium-phosphatecotransporter(NaPi-IIa)
...sofsubstratetransportintherenaltypeIIahumansodium-phosphatecotransporter(NaPi-IIa).ThetransporterwasexpressedinXenopuslaevisoocytes,andsteady-stateandpre-steady-statecurrentsandsubstrateuptakeswerecharacterizedbyvoltage-clampandisotopeflux.First,bymeasuringsimultaneousuptakeofasubstrate(32Pi,22Na)an...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第5期黎族三个支系DYS390、DYS393、DYS395基因座的遗传学研究
...析 等位基因频率用直接记数法,以公式GD=n/(n-1)(1-∑Pi2)计算基因多样性,单倍型多样性,用公式HD=1-∑Pi2,与其他人群比较用Fisher’s精确检验。 2结果 2.1等位基因多样性 在3个基因座检测黎族3个支系人群共...
医源资料库;在线期刊;中国热带医学杂志;2008年第8卷第1期基于VTK的鼻咽部三维重建
...类圆柱表面,每一三角形片的顶点来自P和Q。其形式为(Pi,Pk,Qj)或(Qi,Qk,Pj),这种形式的三角形片有许多,其组合方式数为T=[(m-1)+(n+1)]!(m-1)!(n+1)!为了简化讨论,考虑满足下面条件的三角形片:(1)三角形片中至...
医源资料库;在线期刊;中华现代影像学杂志;2006年第3卷第9期硒对Ox-LDL诱导牛内皮细胞Caspase-3酶的作用
...helialcells.CHENShi-xiong,CHENSheng.(DanzhouMunicipalLandReclamationHospital,Danzhou571700,Hainan,P.R.China) Abstract:ObjectiveToinvestigatetheeffectsofantioxidantseleniumontheoxLDL-inducedapoptosisofbovineaorticen-dothelialcells(BAECs)andrelevantmechanism.MethodsBAECswereisolat...
医源资料库;在线期刊;中国热带医学杂志;2005年第5卷第4期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...theCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailstorecruitGrb2.Toverifythishypothesis,we...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第2期ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...theCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailstorecruitGrb2.Toverifythishypothesis,we...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第2期PostprandialresponsetoaphysiologiccaloricloadinHIV-positivepatientsreceivingproteaseinhibitorbasedornonnucleosidereversetranscriptasein
...ooseveltMedicalCenter,DivisionofInfectiousDisease(SR,RM,andWME-S),HarlemHospitalCenterandColumbiaUniversity,NewYork,NY;theDepartmentofMedicine,UniversityofCaliforniaDavis,Davis,CA(BOandLB);andtheVANorthernCaliforniaHealthCareSystem(LB)2Supportedbygrants65938(principalinvestigator:LB)and65954(princip...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第1期