ModelingtheInfluenceofAPOC3,APOE,andTNFPolymorphismsontheRiskofAntiretroviralTherapyAssociatedLipidDisorders

...totalcholesterol.PatientswhohadaCentersforDiseaseControlandPreventionstageCAIDS-definingeventinthepreceding3monthsoraCD4Tcellcount100cells/Lwereexcluded,tolimitconfoundingbyHIV-associatedwastingandopportunisticillness.Lipoatrophywasdefinedbythepatient-reportedpresenceoffatlossat1bodysite(face,neck,a...

HIVSuperinfection

...ectionwithwild-typevirusafterprimaryinfectionwithdrug-resistantcladeBvirus.AIDS2003;17:F116.Firstcitationinarticle6.BaleJF,PetheramSJ,SouzaIE,MurphJR.Cytomegalovirusreinfectioninyoungchildren.JPediatr1996;128:34752.Firstcitationinarticle7.BissingerAL,OettleH,JahnG,NeuhausP,SinzgerC.Cytomegalovirusin...

MagneticresonancespectroscopyrevealsthatactivatedmonocytescontributetoneuronalinjuryinSIVneuroAIDS

...dicalCenter,Atlanta,Georgia,USA.6GileadSciences,FosterCity,California,USA.7AIDSVaccineProgram,ScienceApplicationsInternationalCorporationFrederickInc.,NationalCancerInstituteatFrederick,Frederick,Maryland,USA.8NeurosciencesDepartment,UCSD,LaJolla,California,USA.AbstractDifficultiesinunderstandingthe...

LowAccumulationofL90MinProteasefromSubtypeFHIV-1withResistancetoProteaseInhibitorsIsCausedbytheL89MPolymorphism

...etroviraltherapy(orhighlyactiveantiretroviraltherapy[HAART])forpatientswithAIDS[14].SevendifferentPIshavebeenapprovedbytheUnitedStatesFoodandDrugAdministration(FDA)andareavailableforclinicaluse:saquinavir(SQV),ritonavir(RTV),indinavir(IDV),nelfinavir(NFV),amprenavir(APV),lopinavir(LPV),and,morerecen...

艾滋病合并结核感染状况的临床分析———附7例临床病例

...防疫站确诊阳性（蛋白印迹法）。（2）肺结核的诊断:①痰结核菌检阳性;②有明显的结核中毒症状;③结核菌素实验中强度阳性;④胸片有较典型的结核影像改变;⑤抗结核治疗有效。具备以上第1项或2～5项中的3项者，可诊断为结...

PersistentGBVirusCInfectionIsAssociatedwithDecreasedHIV-1DiseaseProgressionintheAmsterdamCohortStudy

...etimeofHIV-1seroconversionwithin18monthsin100%ofthesubjectsintheMulticenterAIDSCohortStudy(MACS)[4].Second,thedatabaseusedinVanderBijetal.‘sstudyisincompleterelativetothatusedinWilliamsetal.‘sstudy;intheACS,HIV-1loadsweretestedbeforeJune1996onlyinseroconverters[1],andbothCD4+cellcountsandHIV-1lo...

HIV-1ProteaseandReverse-TranscriptaseMutations:CorrelationswithAntiretroviralTherapyinSubtypeBIsolatesandImplicationsforDrug-ResistanceSurvei

...mutationsweredefinedbyuseof2reviewsonHIV-1drugresistanceandtheInternationalAIDSSocietyUSAexpertpanelmutationlist[1,2,7].Onthebasisofthislistofmutations,proteasepositions10,20,24,30,32,33,36,46,47,48,50,53,54,63,71,73,77,82,84,88,and90werecategorizedasestablishedPI-resistancepositions.RTpositions41,4...

五种人免疫缺陷病毒（HIV）蛋白酶抑制剂在体外对细胞色素P4503A4,3A5和3A7的分化抑制

2006年04月19日BasicClinPharmacolToxicol.2006Jan;98(1):79-8511通过重组CYP3A4,CYP3A5和CYP3A7酶的睾丸素6-β羟化作用在体外研究五种HIV蛋白酶抑制剂（安泼那韦（amprenavir）、印地那韦（indinavir）、那非那韦（nelfinavir）、利托那韦（ritonavir）和沙...

德国研究发现：绿茶成分可降低艾滋病毒传染性

新华网德国病毒学家最近证实，绿茶中的一种活性成分在高浓度状态下能明显降低I型艾滋病病毒的传染性，研究者对这种活性成分的防病毒机理提出了解释。　　据德国媒体18日报道，德国乌尔姆大学医院的研究人员曾于两年前...

使用免疫抑制剂后烟曲霉菌感染的诊治（附7例报告）

...，7例全部有效，其中3例治愈出院；其余4例曾治疗有效，痰培养烟曲霉菌转阴，以后再次感染复发，其中3例死亡，1例自动出院，后果不详。结论伊曲康唑为治疗烟曲霉菌的有效药物；合理使用免疫抑制剂在防治烟曲霉菌等感染...