RateandIncidenceEstimatesofRecentHumanImmunodeficiencyVirusType1InfectionsamongPregnantWomeninSoPaulo,Brazil,from1991to2002
...Services,Berkeley,CaliforniaABSTRACTTheserologicaltestingalgorithmforrecenthumanimmunodeficiencyvirus(HIV)seroconversion(STARHS)wasemployedtoestimateHIVincidenceamongpregnantwomenfromSoPaulo,Brazil.Across-sectionalstudy(1999to2002)showedanincidenceofinfectionof0.2per100pregnantwomenperyear(95%confid...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第3期GeneticPathwaystoPrimaryandSecondaryGlioblastoma
...ffectmainlytheelderlyandaregeneticallycharacterizedbylossofheterozygosity10q(70%ofcases),EGFRamplification(36%),p16INK4adeletion(31%),andPTENmutations(25%).Secondaryglioblastomasdevelopthroughprogressionfromlow-gradediffuseastrocytomaoranaplasticastrocytomaandmanifestinyoungerpatients.Inthepathwayto...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第5期Aninterstitialdeletion-insertioninvolvingchromosomes2p25.3andXq27.1,nearSOX3,causesX-linkedrecessivehypoparathyroidism
...versityofOxford,OxfordCentreforDiabetes,EndocrinologyandMetabolism(OCDEM),ChurchillHospital,Oxford,UnitedKingdom.2MolecularCytogeneticsandMicroscopy,WellcomeTrustCentreforHumanGenetics,UniversityofOxford,Oxford,UnitedKingdom.3DivisionofDevelopmentalGenetics,MedicalResearchCouncil(MRC)NationalInstitu...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期AneuploidyArisesatEarlyStagesofApc-DrivenIntestinalTumorigenesisandPinpointsConservedChromosomalLociofAllelicImbalancebetweenMouseandHuman
...resenceofachromosomalinstabilitydefectatearlystagesoftheadenoma-carcinomasequence.Moreover,lossoftheTp53tumorsuppressorgene,butnotKRASoncogenicactivation,resultsinanincreaseofgainsandlossesofwholechromosomesintheApc-mutantgeneticbackground.Comparativeanalysisoftheoverallgenomicalterationsfoundinmous...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第1期生物丁醇合成关键酶的新型开关机制的解析
...和产溶剂紊乱使产丁醇减少,而不能形成二硫键的CaTHLV77Q/N153Y/A286K酶活性提高,且过表达能产更多的丁醇。结果表明CaTHL是调控丙酮丁醇梭菌主代谢的关键酶,其活性受到新型机制的调控。丁醇是一种四碳直链饱和醇,有广泛化...
医药经济;生物技术;技术要闻Abdominalobesityandcoronaryarterycalcificationinyoungadults:theCoronaryArteryRiskDevelopmentinYoungAdults(CARDIA)Study
...umberinthefocus.Thecoefficientrangedfrom1to4[1=131200Hounsfieldunits(HU),2=201300HU,3=301400HU,and4=401HU].Totalcalciumscoreswereobtainedbysummingalllesionswithinagivenarteryandacrossallarteries(leftmain,leftanteriordescending,leftcircumflex,andrightcoronaryarteries).Eachscansetwit...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第1期细胞因子受体的信号传导
...tractHaemolyticassaysforthesecondcomponentofcomplementwasestablishedbyusinghumanfreshserumandfunctionallypureC1gppreparedbyeuglobulinprecipitatoin.FunctionallypureC2withoutC1andC3~C9activitywaspreparedbyion-exchangechromatographyonCM-SephadexC50.AssemblyoftheclassicalpathwayC3convertaseinvitro...
合作平台;医学论文;临床医学与专科论文;检验医学IdentificationofVibrioparahaemolyticusPandemicGroup-SpecificDNASequencebyGenomicSubtraction
...nsshowedalmostidenticalfragmentpatterns,suggestingthemtobeclonallyrelated,thusformingthe“pandemicgroup.“Nevertheless,westilldonothaveanysubstantialevidencetoexplainthe“pandemicity“ofthesestrains.Inthiscontext,Matsumotoetal.(6)reportedthatthepandemicgroupexhibitedauniquesequence(ToxR/new)with...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期AbnormalitiesofGermCellMaturationandSertoliCellCytoskeletoninAndrogenReceptorCAGKnock-InMiceRevealToxicEffectsoftheMutantProtein
【摘要】Anunresolvedquestioninthestudyofthepolyglutamineneurodegenerativedisordersistheextenttowhichpartiallossofnormalfunctionofthemutantproteincontributestothediseasephenotype.Toaddressthis,westudiedKennedydisease,adegenerativedisorderoflowermotorneuronscausedbyaCAG/glutamineexpansionintheandr...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期Geneticepidemiologyofdiabetes
...ch,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,USA.2DepartmentofHumanGenetics,TheUniversityofChicago,Chicago,Illinois,USA.AbstractConventionalgeneticanalysisfocusesonthegenesthataccountforspecificphenotypes,whiletraditionalepidemiologyismoreconcernedwiththeenvironmentalcausesandriskfactor...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期