ThePoxvirusProteinA52RTargetsToll-likeReceptorSignalingComplexestoSuppressHostDefense
...ranscriptionfactornuclearfactorB(NF-B)bymultipleTLRs,includingTLR3,arecentlyidentifiedreceptorforviralRNA.A52Rassociateswithbothinterleukin1receptor–associatedkinase2(IRAK2)andtumornecrosisfactorreceptor–associatedfactor6(TRAF6),twokeyproteinsimportantinTLRsignaltransduction.Further,A52Rcoulddis...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第3期Trehalose‘-DimycolateandLipidinthePathogenesisofCaseatingGranulomasofTuberculosisinMice
...e,asinhumans,tuberculosisdevelopmentstimulatesaccumulationoflipidselectivelyinalveoli.MTBpreferentiallyassociatedwithlipiddropletsindevelopingnecroticfociinlate-stagemurinetuberculosis.ThissupportsthehypothesisthatpulmonarytuberculosissequestersMTBinaprotectedenvironmentthataccumulateslipiduntilitis...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期CytosolicrecognitionofflagellinbymousemacrophagesrestrictsLegionellapneumophilainfection
...antsreplicatedfreely.Likewise,afterintratrachealinoculationofNaip5+mice,theyieldofL.pneumophilainthelungsdeclined,whereastheburdenofflagellinmutantsincreased.Accordingly,macrophagesrespondtocytosolicflagellinbyamechanismthatrequiresNaip5andcaspase1torestrictbacterialreplicationandreleaseproinflammat...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第4期MultilocusDNASequenceComparisonsRapidlyIdentifyPathogenicMolds
...served.WehypothesizedthatDNAsequenceanalysisofmultiplelociisusefulforrapidlyidentifyingmedicallyimportantmolds.OurstudyincludedtheanalysisoftheD1/D2hypervariableregionofthe28Sribosomalgeneandtheinternaltranscribedspacer(ITS)regions1and2oftherRNAoperon.Twohundredonestrains,including143clinicalisolate...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第7期SuppressionoftumorformationinlymphnodesbyL-selectin–mediatednaturalkillercellrecruitment
...thelialcellsareessentialforNKcellrecruitmenttolymphnodes.Furthermore,freshlyisolatedresidentlymphnodeNKcellslysedtumorsefficiently,andmetastasisofB16melanomacellstodraininglymphnodeswassuppressedinwild-typeorRag-1–deficientmice,butnotwhenNKcellsweredepleted.AlthoughL-selectin–deficientNKcellseff...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第12期SynergyofIL-21andIL-15inregulatingCD8+Tcellexpansionandfunction
...ealthatIL-21potentlyregulatesCD8+Tcellexpansionandeffectorfunction,primarilyinasynergisticcontextwithIL-15.Abbreviationsused:CFSE,5,6-carboxyfluoresceindiacetatesuccinimidylester;rFPVhgp100,recombinantfowlpoxvirusencodinghgp100;vPE16,vacciniavirus–expressingHIVgp160.Thecommoncytokinereceptor-chain...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第1期阻塞性睡眠呼吸暂停低通气综合征的治疗
...UPPP,中度患者改良UPPP联合鼻部手术可提高有效率。阻塞性睡眠呼吸暂停低通气综合征(OSAHS)临床最为常见,主要表现为睡眠打鼾并伴有呼吸暂停和呼吸表浅,夜间反复发生低氧血症、高碳酸血症和睡眠结构紊乱,导致白天嗜睡、...
行业资讯;临床快报;呼吸系统相关中小学生伤害干预效果的Meta分析
...与发生伤害的人次数(或人数)之差。利用公式Q=∑wi(yi-y)2对资料进行一致性检验。若资料同质,用固定效应模型(Peto法)计算上述OR值及其95%可信区间;若资料不同质,则采用随机效应模型(D-L法)。1.4伤害干预效果评价指...
医源资料库;在线期刊;中国学校卫生;2007年第27卷第6期AutocrinePDGFRsignalingpromotesmammarycancermetastasis
...duringcancerprogression,suggestinganovelapplicationofSTI571totherapeuticallyinterferewithmetastasis.IntroductionCarcinomasaccountformorethan80%ofhumancancers,generatedthroughamultistepprocess(1)eventuallyleadingtometastasis,themajorcauseofcancermorbidity.Innormalepithelia,homeostasis,differentiation...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期丙泊酚瑞芬太尼靶控全静脉麻醉用于眶内手术
...ilintotalintravenousanesthesiainophthalmicorbitalsurgeryZHANGCai-xia,LVGuo-yi.DepartmentofAnesthesiology,TheSecondHospitalofTianjinMedicalUniversity,Tianjin300211,China[Abstract]ObjectiveToinvestigatethefeasibilityandsafetyoftargetcontrolledinfusion(TCI)withpropofolandremifentanilintotalin...
医源资料库;在线期刊;中华现代眼耳鼻喉杂志;2009年第6卷第2期