第二节 突变和选择
...因频率将保持不变,维持了遗传平衡状态。即:(1-q)u=qvu=qu=qvu=qu+qvu=q(u+v)q=μ/u+vp=v/u+v 在此情况下,突变频率完全由u和v来决定。突变有时导致一个基因功能的丧失或变化。大多数可检测的突变是有害的,因此有突变就会面临选...
医源资料库;医源图书馆;教材类;医学遗传学基础Findingschizophreniagenes
...tment,thetypicalcourseisoneofrelapsesfollowedbyonlypartialremissionaswellasamarkedreductioninsocialandoccupationalfunctionsuchthatsufferersareoftenthemostvulnerable,isolated,anddisadvantagedindividualsinsociety.Inarecentmetaanalysisthemedianincidenceratewas15.2per100,000,withthe10%to90%quantilesbetw...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期SyntheticRetinoidAm80ReducesScavengerReceptorExpressionandAtherosclerosisinMicebyInhibitingIL-
...ptorsfacilitatetheuptakeofmodifiedlow-densitylipoprotein(LDL),formationoffoamcells,anddevelopmentofatherosclerosis.Giventhatproinflammatorycytokines,includingIL-6,canmodulatethemacrophagefoamingprocess,theaimofthepresentstudywastodeterminewhetherthesyntheticretinoicacidreceptor-/ß-specificagon...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第5期Dynamicchangesinfatoxidationinhumanprimarymyocytesmirrormetaboliccharacteristicsofthedonor
...ityof16healthy,youngmalesubjectswasdeterminedbyeuglycemichyperinsulinemicclamp.Musclesampleswereobtainedfromvastuslateralis,cultured,anddifferentiatedintomyotubes.Inhumanmyotubesinvitro,wemeasuredsuppressibility(glucosesuppressionofFOx)andadaptability(anincreaseinFOxinthepresenceofhighpalmitateconce...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期严重烧伤早期大鼠肺泡巨噬细胞CD14的表达及调控*
【摘要】目的探讨严重烧伤对大鼠肺泡巨噬细胞(AM)CD14膜蛋白(CD14)和mRNA基因表达变化的影响,以及抗CD14抗体对AM产生肿瘤坏死因子α(TNF-α)和白介素6(IL-6)的调控作用。方法20%Ⅲ度烧伤大鼠检测早期外周血内毒素(LPS)...
医源资料库;在线期刊;中华实用医药杂志;2008年第8卷第3期MorphologicFindingsofCoronaryAtheroscleroticPlaquesinDiabetics
...yMedicalCenter,Washington,DC.ABSTRACTObjective—Coronaryatheroscleroticplaquecompositionofdiabeticsubjectsandlocalizationofreceptorforadvancedglycationendproducts(RAGE)anditsligandshavenotbeenextensivelystudied.MethodsandResults—Heartsfromdiabeticsubjectsandage,race,andsex-matchednondiabeticsubje...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第7期InvolvementofPPARnuclearreceptorsintissueinjuryandwoundrepair
...iersinGenetics,“UniversityofLausanne,Lausanne,Switzerland.AbstractTissuedamageresultingfromchemical,mechanical,andbiologicalinjury,orfrominterruptedbloodflowandreperfusion,isoftenlifethreatening.Thesubsequenttissueresponseinvolvesanintricateseriesofeventsincludinginflammation,oxidativestress,immun...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期Kidneystonedisease
...tmentofAnatomy,IndianaUniversity,Indianapolis,Indiana,USA.AbstractAbout5%ofAmericanwomenand12%ofmenwilldevelopakidneystoneatsometimeintheirlife,andprevalencehasbeenrisinginbothsexes.Approximately80%ofstonesarecomposedofcalciumoxalate(CaOx)andcalciumphosphate(CaP);10%ofstruvite(magnesiumammoniumphosp...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第10期组织多普勒超声心动图对糖尿病患者左室功能的评价
...舒张早期峰值运动速度(Em)与舒张晚期峰值运动速度(Am)以及Em/Am;计算E/Em值。结果(1)两组糖尿病患者Sm显著低于正常对照组(P<0.01),DM+LVH组Sm又显著低于DM组(P<0.05);(2)两组糖尿病患者E/A≤1与Em/Am≤1检出率显著...
医源资料库;在线期刊;中华现代影像学杂志;2007年第4卷第2期BradycardiaStimulatesVascularGrowthDuringGradualCoronaryOcclusion
...fVeteransAffairs(K.G.L.,D.X.,J.M.),IowaCity,Iowa.CorrespondencetoKathrynG.Lamping,PhD,VAMedicalCenter,601Highway6W,IowaCity,IA52246.E-mailkathryn-lamping@uiowa.eduAbstractObjective—Inculturedendothelium,stretchinducesreleaseofgrowthfactorsthatcontributetoangiogenesis.Wetestedthehypothesisthatbrady...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第10期