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MyD88-dependentIL-1receptorsignalingisessentialforgoutyinflammationstimulatedbymonosodiumuratecrystals
...lsstimulatedacuteinflammation.Figure1MSUinducesperitonitisinmice.(AandB)C57BL/6micewerechallengedi.p.with3mgofMSUcrystals.MicechallengedwithPBSservedasnegativecontrols.PeritonealcellswerestainedforLy-6Gand7/4expressionandanalyzedbyflowcytometry.(A)RepresentativedotplotsofLy-6Gand7/4expressiononperit...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第8期 -
二、种系
...系特征。例如DBA/2小鼠100%的可发生听源性癫痫发作；而C57BL小鼠根本不出现这种反应。BALB/cAnN小鼠对放射线极敏感；而C57BR/CdJN小鼠放射线却具有抗力。C57L/N小鼠对疟原虫易感，而C58/LwN、DBA/1JN小鼠对疟原虫感染有抗力。STR/N小鼠...
医源资料库；医源图书馆；教材类；医用实验动物学 -
BlockadeoftheFas/FasLSystemImprovesPneumococcalClearancefromtheLungswithoutPreventingDisseminationofBacteriatotheSpleen
...or3(DcR3),anaturallyoccurringdecoyreceptor.WedeterminedtheeffectsofsystemicblockadeoftheFas/FasLsystembyaDcR3analog(DcR3-a)inmicewithpneumococcalpneumonia.Methods.Streptococcuspneumoniae(7.2×105or1.9×107cfu/mL)wasinstilledintratracheallyintountreatedC57Bl/6mice,C57Bl/6micetreatedwithDcR3-a,orFas-d...
医源资料库；在线期刊；传染病学杂志；2005年第191卷第4期 -
Therelativecontributionsofeachsubsetofocularinfiltratedcellsinexperimentalchoroidalneovascularisation
...isco,CA94143,USAABSTRACTAim:Choroidalneovascularisation(CNV)isamajorcauseofblindnessinadults.TheaimofthisstudywastoinvestigatetheroleofinfiltratingcellsinthedevelopmentofexperimentalCNV.Methods:CNVwasinducedinC57BL/6(B6)micebylaserphotocoagulation(PC).AfterPC,thenumbersofeachsubsetofinfiltratedcells...
医源资料库；在线期刊；英国眼科学杂志；2004年第88卷第9期 -
CD+TCellsPromoteInflammationandApoptosisintheLiverafterSepsis
【摘要】AlthoughstudiesblockingtheFaspathwayindicateitcandecreaseorgandamagewhileimprovingseptic(cecalligationandpuncture,CLP)mousesurvival,littleisknownabouthowFas-Fasligand(FasL)interactionsmediatethisprotectionatthetissuelevel.Here,wereportthatalthoughFasexpressiononsplenocytesandhepatocytesi...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第7期 -
成人大脑也有创造新神经通路能力
...同事们研究了一名中风患者的大脑，他们把患者简称为“BL”。丹尼尔·迪尔克斯是约翰·霍普金斯大学攻读研究生时完成这项研究的。BL中风损害了把信息从眼睛传送到初级视觉皮层的神经纤维。初级视觉皮层是大脑后面灰质中...
行业资讯；临床快报；神经科 -
主要组织相容性复合物单体型与小鼠疱疹后疼痛相关
...生中的作用。研究中使用BALB/c小鼠（MHC单体型：H-2）、C57BL/6小鼠（MHC单体型：H-2）和BALB/b小鼠（单体型为H-2的BALB/c同类株）。I型单纯疱疹病毒经皮接种至小鼠后爪，造成单侧带状疱疹样皮肤病损和疼痛相关反应（急性疱疹痛）...
行业资讯；临床快报；神经科 -
Platelet,NotEndothelial,P-SelectinIsRequiredforNeointimalFormationAfterVascularInjury
...lidAve,Cleveland,OH44195.E-mailwangk@ccf.orgAbstractBackground—P-selectinblockadesignificantlyinhibitsinflammationandneointimalformationafterarterialinjury;however,theindependentrolesofplateletandendothelialP-selectinsinthisprocessareunknown.Inatherosclerosis,bothplateletandendothelialcellP-select...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第8期 -
ACannabinoidQuinoneInhibitsAngiogenesisbyTargetingVascularEndothelialCells
...potentialasanewantiangiogenicandanticancerdrug.Angiogenesis,theprocessofnewbloodvesselformation,iscrucialforthedevelopmentandprogressionofpathogenicprocessesofavarietyofdisorders,includingtumorgrowth(Folkman,1995).Muchefforthasbeeninvestedintothedevelopmentofcompoundswithantiangiogenicactivity.Thefi...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第7期 -
TheRoleofInterstitialMacrophagesinNephropathyofTypeDiabeticdb/dbMice
...buttheircontributiontodiseaseprogressionisunclear.Weaddressedthisquestionbyblockadeofchemokinereceptor(CCR)1becauseCCR1mediatesthemacrophagerecruitmenttotherenalinterstitium.Infact,whenCCR1wasblockedwithBL5923,anovelorallyavailableCCR1antagonist,theinterstitialrecruitmentofexvivolabeledmacrophageswa...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第4期