AllelicVariantsoftheHumanScavengerReceptorClassBType1andParaoxonase1onCoronaryHeartDisease
...ioncloningofSR-BI,aCD36-relatedclassBscavengerreceptor.JBiolChem.1994;269:21003–21009.CalvoD,VegaMA.Identification,primarystructure,anddistributionofCLA-1,anovelmemberoftheCD36/LIMPIIgenefamily.JBiolChem.1993;268:18929–18935.TrigattiBL,KriegerM,RigottiA.InfluenceoftheHDLReceptorSR-BIonLipoprotei...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第4期Low-DensityLipoproteinFromApolipoproteinE-DeficientMiceInducesMacrophageLipidAccumulationinaCD36andScavengerReceptorClassA-DependentManner
...06cells/12-wellplateinDMEMcompletemediumcontaining10%heat-inactivatedFCSand1000IU/mLrecombinanthumanM-colony-stimulatingfactor(CSF).Adherentcellswerewashedafterovernightincubationandused.LDLParticleIsolationandRadiolabelingApoE–/–,LDLr–/–,andC57BL/6mice(20to30each)werefasted6hoursbeforeblood...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2005年第25卷第1期Humanaldosereductaseexpressionacceleratesdiabeticatherosclerosisintransgenicmice
...AR-Ldlr+/–mice.Tworepresentativemicefromeachgroupareshown.Magnification,x100.MacrophagesfromhAR-expressingmicehaveincreasedexpressionofinflammatorymarkers.WeassessedwhetherhARexpressionwaspresentinatheroscleroticlesions.StainingoflesionsforARexpressionusingananti-hARpolyclonalantibodyshowedrobusth...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第9期婴幼儿奶粉中病原菌多重PCR检测研究
...Ying,etal. 1.CollegeofPublicHealth,ChineseMedicalUniversity,Shenyang,110001; 2.BasicCollegelofLiaoningUniversityofChineseTraditionaMedicine,Shenyang110001,Liaoning,P.R.China Abstract:ObjectiveToestablishamultiplePCRmethodfordetectionofcommonpathogenicbacteriasuchasEnterobacterSakaza...
医源资料库;在线期刊;中国热带医学杂志;2008年第8卷第10期丙型肝炎病毒DNA核酸免疫的初步探讨
...院传染病研究所卫生部病毒性传染病重点实验室,杭州310003关键词:HCV-DNA重组体;核酸免疫;抗体反应;细胞免疫 中国图书分类号 R512.63 摘 要 目的:探索HCV-DNA核酸免疫效应。方法:将构建的重组体pCD-HCVs免疫Balb/c...
合作平台;医学论文;临床医学与专科论文;检验医学清道夫受体介导的脂质蓄积的分子机制
...npatternsofSRAmutant:*P0.05,n=3EGFPSR-AN3132LMEGFPSR-AN3132LM*02004006008001000controlEGFPSR-AN3132LM(3)TheinternalizationofDiI-AcLDLviaSRAmutant:DiI-acLDLSR-Aexpression**DiI-acLDL*P0.05,n=3**P0.05,n=3010203040EGFPWildtypeN3132LM*EGFPWildtypeN3132LM0.020.040.060.080.100.12(4)CelladhesionviaSRAmutant...
医源资料库;医学文档库;心血管相关IncreasedOxidativeStressinScavengerReceptorBIKnockoutMiceWithDysfunctionalHDL
...BIknockoutmice(71±3nmol/mL/min;n=12)ascomparedwithwild-typecontrols(100±6nmol/mL/min;n=12),whereasthearylesteraseactivitywas1.6-fold(P<0.01)lower(47±4µmol/mL/minand76±7µmol/mL/min,respectively).Inbothgroupsofmice<1%ofthePON1activitywasassociatedwithapoB-contai...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第11期EndocannabinoidactivationathepaticCB1receptorsstimulatesfattyacidsynthesisandcontributestodiet-inducedobesity
...wereobservedinhepatocytesisolatedfromwild-typemice:incubationofthecellswith100nMHU210for60minutessignificantlyincreasedtheincorporationofsubsequentlyadded3H2Ointofattyacids.Theeffectwasattenuatedinthepresenceof10nMSR141716andwasabsentincellsfromCB1–/–mice(Figure2B).Figure2ActivationofCB1stimulat...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第5期ScavengerReceptorsonSinusoidalLiverEndothelialCellsAreInvolvedintheUptakeofAldehyde-ModifiedProteins
...hthroughtheliverataflowrateof20ml/min(2.5–3ml/min/gofliver).Theadditionof100xunlabeledMAA-Alb,f-Alb,Maley-Alb,AGE-Alb,fucoidan,orfetuinwasmixedwiththeaboveradioactiveligandforinhibitionstudies.After3hofincubation,0.5-mlaliquotswereremovedand2.0mlof20%trichloroaceticacidand2%phosphotungsticacidwasa...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期武汉大学Cell文章揭示转录的奥秘
...系。他在美国曾获得两项专利,在国际学术期刊发表论文100多篇,其中发表在Nature,Science,Cell三大顶级期刊上的论文有10余篇。在分子生物学,生物化学等领域有较深造诣,在生命科学界傅向东因发现SR家族的剪接因子和一个新...
医药经济;生物技术;技术要闻