GlycogenSynthaseKinase3RegulatesN-Methyl-D-aspartateReceptorChannelTraffickingandFunctioninCorticalNeurons
【关键词】GlycogenEmergingevidencehassuggestedthatglycogensynthasekinase3(GSK-3)isakeyregulatorykinaseinvolvedinaplethoraofprocessesinthenervoussystem,includingneuronaldevelopment,moodstabilization,andneurodegeneration.However,thecellularmechanismsunderlyingtheactionsofGSK-3remaintobeidentified...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期LackofEffectofPravastatinonCerebralBloodFloworParenchymalVolumeLossinElderlyatRiskforVascularDisease
...lynormalelderlywithseverewhitematterlesions.EurJNeurol.1998;5:143–149.RománGC,ErkinjuttiT,WallinA,PantoniL,ChuiHC.Subcorticalischaemicvasculardementia.LancetNeurol.2002;1:426–436.EndresM,LaufsU,HuangZ,NakamuraT,HuangP,MoskowitzMA,LiaoJ.Strokeprotectionby3-hydroxy-3methylglutaryl(HMG)-CoAreducta...
医源资料库;在线期刊;中风学杂志;2005年第36卷第8期TheN-TerminalDomainsofbothNR1andNR2SubunitsDetermineAllostericZn2+InhibitionandGlycineAffinityofN-Methyl-D-aspartateReceptors
【关键词】N-TerminalTheN-methyl-D-aspartate(NMDA)subtypeofionotropicglutamatereceptors(iGluRs)isatetramericproteincomposedofhomologousNR1andNR2subunits,whichrequirethebindingofglycineandglutamate,respectively,forefficientchannelgating.TheextracellularN-terminaldomains(NTDs)ofiGluRsubunitsshowse...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第12期PrognosticValueofCerebralPerfusion-ComputedTomographyintheAcuteStageAfterSubarachnoidHemorrhagefortheDevelopmentofDelayedCerebralIschemia
...e—Delayedcerebralischemia(DCI)isanimportantcauseofdeathanddisabilityaftersubarachnoidhemorrhage.Westudiedtheadditionalprognosticvalueofbrainperfusionto3establishedpredictors(age,clinicalconditiononadmission,andamountofsubarachnoidblood)forthedevelopmentofDCI.Methods—Weincluded69patientsscannedwi...
医源资料库;在线期刊;中风学杂志;2006年第37卷第2期PeroxideIsaKeyMediatorofBcl-2Down-RegulationandApoptosisInductionbyCisplatininHumanLungCancerCells
...4°C,thesupernatantswerecollectedanddeterminedforproteincontentusingbicinchoninicacidassay.Proteins(40µg)wereresolvedona10%SDS-polyacrylamidegelandtransferredontonitrocellulosemembranes(Bio-RadLaboratories,Hercules,CA).Thetransferredmembraneswereblockedfor1hin5%nonfatdrymilkin25mMTris-HCl,p...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期-GlutamylcysteineSynthetaseMediatesthec-Myc-DependentResponsetoAntineoplasticAgentsinMelanomaCells
...elsandcytotoxicity.MolCarcinog45:635-647.16491484[CrossRef][Medline]deAlboránIM,BaenaE,andMartinez-AC(2004)c-MycdeficientBlymphocytesareresistanttospontaneousandinducedcelldeath.CellDeathDiffer11:61-68.12970677Firstauthornamedoesnotmatch(deAlborán).[CrossRef][Medline]DenekeSMandFanburgBL(1989)Regu...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期Brain-DerivedNeurotrophicFactor:LinkingFearLearningtoMemoryConsolidation
...eroftheneurotrophinfamily,playsanimportantroleinsynapticplasticity.InthisissueofMolecularPharmacology,OuandGean(p.350)thoroughlydescribethemolecularcascadebywhichfearlearningleadstoanincreaseinBDNFexpressioninthelateralamygdala(LA).CalciuminfluxthroughN-methyl-D-aspartatereceptorsandL-typevoltage-de...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第8期Fn14IsUpregulatedinCytokine-StimulatedVascularSmoothMuscleCellsandIsExpressedinHumanCarotidAtheroscleroticPlaques
...ingproteins.PhysiolRev.2001;81:153–208.Blanco-ColioLM,VillaA,OrtegoM,Hernández-PresaMA,PascualA,PlazaJJ,EgidoJ.3-Hydroxy-3-methyl-glutarylcoenzymeAreductaseinhibitors,atorvastatinandsimvastatin,induceapoptosisofvascularsmoothmusclecellsbydownregulationofBcl-2expressionandRhoAprenylation.Atheroscl...
医源资料库;在线期刊;中风学杂志;2006年第37卷第8期龙灯CIBUS共推非转基因抗除草剂油菜
...合作协议,联合开发抗除草剂油菜新品种——抗磺脲类(SU)除草剂油菜,以满足各国对高品质、非转基因菜籽油日益增长的需求。 据了解,全球油菜籽产量增长迅速,在过去40年中,从第六大油料作物上升到第二位。1999年...
医药经济;生物技术;技术要闻犬类驯化时间或早于预期
...学报》(2015-05-25第2版国际)更多阅读《自然》相关报道(英文)作者:鲁捷
医药经济;生物技术;技术要闻