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NH2terminusofserumandglucocorticoid-regulatedkinase1bindstophosphoinositidesandisessentialforisoform-specificphysiologicalfunctions
...GK1intheirNH2-terminaldomains.WefoundthatSGK1andSGK3arepotentstimulatorsofepithelialNa+channel(ENaC)-dependentNa+transport,whileSGK2,whichhasashortNH2terminus,isaweakstimulatorofENaC.FurthercharacterizationoftheroleoftheSGK1NH2terminusrevealedthatitsdeletiondoesnotaffectinvitrokinaseactivitybutprofo...
医源资料库；在线期刊；美国生理学杂志；2007年第290卷第6期 -
Functionalandmetabolicearlychangesincalfmuscleoccurringduringnutritionalrepletioninmalnourishedelderlypatients
IsabelleBourdel-Marchasson,Pierre-AlainJoseph,PatrickDehail,MarcBiran,PascalFaux,MurielRainfray,Jean-PaulEmeriau,PaulCanioniandEricThiaudière1FromtheDépartementdeGériatrieduCentreHospitalo-UniversitairedeBordeaux,HôpitalXavierArnozan,CentreHospitalier-UniversitairedeBordea...
医源资料库；在线期刊；美国临床营养学杂志；2001年73卷第4期 -
Phosphatidylinositol3-KinaseeCAktPathwayPlaysaCriticalRoleinEarlyCardiomyogenesisbyRegulatingCanonicalWntSignaling
...AbstractWehaverecentlyreportedthatactivationofphosphatidylinositol3-kinase(PI3K)playsacriticalroleintheearlystageofcardiomyocytedifferentiationofP19CL6cells.WehereexaminedmolecularmechanismsofhowPI3Kisinvolvedincardiomyocytedifferentiation.DNAchipanalysisrevealedthatexpressionlevelsofWnt-3aweremarke...
医源资料库；在线期刊；循环研究杂志；2005年第95卷第7期 -
ATP的生成、储存和利用
...念。氧化是底物脱氢或失电子的过程，而磷酸化是指ADP与Pi合成ATP的过程。在结构完整的线粒体中氧化与磷酸化这两个过程是紧密地偶联在一起的，即氧化释放的能量用于ATP合成，这个过程就是氧化磷酸化，氧化是磷酸化的基础...
药品天地；专业药学；实验技术；生化实验；酶学实验 -
RegulationofHumanConeCyclicNucleotide-GatedChannelsbyEndogenousPhospholipidsandExogenouslyAppliedPhosphatidylinositol3,4,5-trisphosphate
...CNGA3+CNGB3channelswerepreventedbyinhibitionofphosphatidylinositol3-kinase(PI3-kinase)usingwortmanninor2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-onehydrochloride(LY294002),whichsuggeststhatphospholipidmetabolismcanregulatethechannels.Directapplicationofphosphatidylinositol3,4,5-trisphosphate(PIP...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第1期 -
缺血后处理对缺血再灌注心脏保护的研究现状及展望
...活相关的丝裂原活化蛋白激酶（MAPKs）和磷酸肌醇3激酶（PI3K）等系统，共有的细胞保护效应包括抑制中性粒细胞活化和氧自由基产生、抑制心肌细胞钙超载、减少缺血再灌注后心肌坏死和凋亡等。IPC是迄今已知最强的缺血心肌...
医源资料库；在线期刊；滨州医学院学报；2008年第31卷第5期 -
InsulinIncreasesthePotencyofGlycineatIonotropicGlycineReceptors
...lplasticityandpainprocessesremainpoorlyunderstood.Herewereportthatinsulinrapidlyincreasesthefunctionofglycinereceptorsinmurinespinalneuronsandrecombinanthumanglycinereceptorsexpressedinhumanembryonickidneycells.Whole-cellpatch-clamprecordingsshowedthatinsulinreversiblyenhancedcurrentevokedbyexogenou...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第5期 -
Alterationsincell-adhesiveandmigratorypropertiesofproximaltubuleandcollectingductcellsfrombcl-2-/-mice
...ellswasmoderatelyaffectedbyincubationwithPD-98059(MEKinhibitor)orLY-294002(PI3kinaseinhibitor),whereasincubationwithSB-203580hadnoeffect.P10bcl-2-/-collectingductcellsalsoexpressedincreasedlevelsoffibronectinbutdecreasedlevelsofthrombospondin-1anddemonstratedprecociousbindingtofibronectinandvitronec...
医源资料库；在线期刊；美国生理学杂志；2004年第287卷第12期 -
MolecularBasisofCellMembraneEstrogenReceptorInteractionWithPhosphatidylinositol3-KinaseinEndothelialCells
...lsignalingmechanismsmediatesomeofthebiologicaleffectsofestrogen,suchastherapidactionsonthebloodvessels.Byinteractingwithphosphatidylinositol3-kinase(PI3K),estrogenreceptor(ER)leadstoactivationofproteinkinaseAktandtosubsequentincreaseinendothelialnitricoxidesynthaseactivity.BecausePI3Kismainlyacytopl...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2003年第23卷第2期 -
两性离子流动相离子色谱法测定硼酸根
...测硼酸根，利用混合两性离子淋洗系统。该系统混合不同pI值的两性离子（pI值大于7的，称为碱性两性离子Zb；pI值小于7的，称之为酸性两性离子Za）,混合后淋洗液的pH值介于pIb和pIa之间，形成了Zb－和ZHa＋，具有一定的淋洗强度...
药品天地；专业药学；实验技术；色谱技术；色谱分析实例