IncreasedInsulin-StimulatedExpressionofArterialAngiotensinogenandAngiotensinType1ReceptorinPatientsWithType2DiabetesMellitusandAtheroma
...CE)andAT1receptor(AT1R)weredeterminedincarotidatheromaplaque,nearbymacroscopicallyintacttissue(MIT),andinvascularsmoothmusclecells(VSMCs)beforeandafterinsulinstimulationfrom21T2Dand22CTRpatients.AGTandACEmRNAandtheirproteinlevelswere2-to3-foldhigherinatheromaandinMITofT2Dpatients.VSMCsfromT2Dpatient...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第3期Transplantationofspermatogonialstemcellsisolatedfromleukemicmicerestoresfertilitywithoutinducingleukemia
...on.Thesortedgermcell–enrichedfractionsweretransplantedintothetestesofrecipientmiceexposedtoalkylatingagents.Transplantedgermcellscolonized,andrecipientmicesurvived.Normalprogenywereproducedbyintracytoplasmicinjectionofspermobtainedfromrecipienttestes.Whenunsortedgermcellsfromleukemicmiceweretransp...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期Phosphoinositide-dependentkinase1targetsproteinkinaseAinapathwaythatregulatesinterleukin4
...minantnegative;KH,kinasehyperactive;PDK1,phosphoinositide-dependentkinase1;PI3K,phosphatidylinositol3-kinase;PIF,PDK-interactingfragment;PKA,proteinkinaseA;PKAc,PKAcatalyticsubunit;RNAi,RNAinterference;siRNA,smallinterferingRNA.Tcellsplayacriticalroleinnormalimmuneresponsesandinthepathogenesisofmany...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第7期TheTransformingGrowthFactor-SuperfamilyMemberGrowth-DifferentiationFactor-15ProtectstheHeartFromIschemia/ReperfusionInjury
...rmanentcoronaryarteryligation.MyocardialGDF-15mRNAandpro-peptideabundancerapidlyincreasedinthearea-at-riskafterischemicinjury.Similarly,patientswithanacutemyocardialinfarctionhadenhancedmyocardialGDF-15pro-peptideexpressionlevels.Asshownbyimmunohistochemistry,cardiomyocytesintheischemicareacontribut...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第2期ComparisonofImmunohistochemistryandVirusIsolationforDiagnosisofWestNileVirus
...lectingducts.Cellsthatstainedappearedtobeacombinationofmacrophages,tubularepithelialcells,andcellsofunknownorigin.Inhearttissue,stainingrangedfromfaintandfocaltooverwhelminganddiffuseandwasmostcommonlyseeninmyofibersandinfiltratingmacrophages.Staininginbraintissuewasusuallyfocalandoftenrare.Thesefoc...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期TheadaptormoleculesLATandSLP-76arespecificallytargetedbyYersiniatoinhibitTcellactivation
...ells;MCC,mothcytochromec;MOI,multiplicityofinfection;PH,pleckstrinhomology;PI3K,phosphoinositide3–kinase;SLAP-130,SLP-76–associatedphosphoproteinof130kD;SLP-76,SH2-domain–containingleukocyteproteinof76kD;YFP,yellowfluorescentprotein.Thesuccessofapathogeninestablishinganinfectionisdependentonit...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第3期ANaphthoquinoneDerivative,Shikonin,HasInsulin-LikeActionsbyInhibitingBothPhosphataseandTensinHomologDeletedonChromosome10andTyrosinePhosph
...sfarweakerthanthatofpervanadate,awidelyusedtyrosinephosphataseinhibitor,despitetheobservationthattheeffectofshikoninonPKBwasmorepotentthanthatofpervanadate.TheseresultssuggestedthattheinhibitionofPTENprovidesacluetoitspotentinsulin-likeactions.Wealsofoundthatnaphthoquinones,including1,2-naphthoquino...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期RegulationofHumanConeCyclicNucleotide-GatedChannelsbyEndogenousPhospholipidsandExogenouslyAppliedPhosphatidylinositol3,4,5-trisphosphate
...CNGA3+CNGB3channelswerepreventedbyinhibitionofphosphatidylinositol3-kinase(PI3-kinase)usingwortmanninor2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-onehydrochloride(LY294002),whichsuggeststhatphospholipidmetabolismcanregulatethechannels.Directapplicationofphosphatidylinositol3,4,5-trisphosphate(PIP...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第1期ApolymorphismintheEAAT2promoterisassociatedwithhigherglutamateconcentrationsandhigherfrequencyofprogressingstroke
1DepartmentofNeurology,HospitalUniversitarioDoctorJosepTrueta,17007Girona,Spain2DepartmentofPharmacology,SchoolofMedicine,UniversityComplutensedeMadrid,28040Madrid,Spain3DepartmentofNeurology,HospitalUniversitarioLaPrincesa,28006Madrid,Spain4DepartmentofNeurology,HospitalClínicoUniversitario,Univer...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期AutocrinePDGFRsignalingpromotesmammarycancermetastasis
...herapeuticintervention.HereweshowthatmetastaticpotentialofoncogenicmammaryepithelialcellsrequiresanautocrinePDGF/PDGFRloop,whichisestablishedasaconsequenceofTGF-?–inducedepithelial-mesenchymaltransition(EMT),afaithfulinvitrocorrelateofmetastasis.ThecooperationofautocrinePDGFRsignalingwithoncogenic...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第6期