RoleoftheOuter-SheetinDivalentCationModulationof7NicotinicReceptors
...tothatobservedinotherAChRs.Inthechick7AChR,thismodulationinvolvesaconservedglutamateinloop9(Glu172)thatundergoesagonist-dependentmovementsduringactivation.Fromtheseobservations,wehypothesizedthatmovementsofthenearby-sheetformedbythe7,9,and10strandsmaybeinvolvedinagonistactivationand/ordivalentmodula...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期MycobacteriaTargetDC-SIGNtoSuppressDendriticCellFunction
...alciumions(12),andtheaminoacidresiduesthatareinclosecontactwithCa2+atsite2(Glu347,Asn349,Glu354,andAsn365)formthecoreoftheligandbindingsite(19,22).ChanginginDC-SIGNeitherGlu347intoGln(E347Q),orAsn349andAsn365intoAsp,resultedincompletelossofbindingtoviablemycobacteriaandManLAM(b,andunpublisheddata),a...
医源资料库;在线期刊;美国病理学杂志;2003年第162卷第1期MycobacteriaTargetDC-SIGNtoSuppressDendriticCellFunction
...alciumions(12),andtheaminoacidresiduesthatareinclosecontactwithCa2+atsite2(Glu347,Asn349,Glu354,andAsn365)formthecoreoftheligandbindingsite(19,22).ChanginginDC-SIGNeitherGlu347intoGln(E347Q),orAsn349andAsn365intoAsp,resultedincompletelossofbindingtoviablemycobacteriaandManLAM(b,andunpublisheddata),a...
医源资料库;在线期刊;实验医学杂志;2003年第197卷第1期ERKandp38mediatehigh-glucose-inducedhypertrophyandTGF-expressioninrenaltubularcells
...LC-PK1cells,phosphorylationofERKandp38increasedafter24-to72-hexposuretohighglucose(HG).Coincubationwithap38inhibitorSB-203580oraMEKinhibitor,PD-98059,suppressedtheHG-inducedincreasesinproteincontent,[3H]leucineincorporation,andtheprotein-to-DNAratio.SB-203580orPD-98059alsoabolishedtheHG-stimulatedex...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第1期TheHumanUDP-Glucuronosyltransferase:IdentificationofKeyResidueswithintheNucleotide-SugarBindingSite
【关键词】HumanUDP-glucuronosyltransferases(UGTs)playimportantrolesinthemetabolism,detoxification,andclearanceofmanydifferentxenobiotics,includingdrugsandendogenouscompounds.Structuralinformationaboutthesemembrane-boundenzymesoftheendoplasmicreticulumislimited.Wedonotknowtheidentityorthelocatio...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期Soy-isoflavone-enrichedfoodsandinflammatorybiomarkersofcardiovasculardiseaseriskinpostmenopausalwomen:interactionswithgenotypeandequolproduct
...223;[ERß(AluI)andERß[cx](Tsp509I),endothelialnitricoxidesynthase(Glu298Asp),apolipoproteinE(ApoE2,E3,andE4),andcholesterylestertransferprotein(TaqIB)]andequolproductionwereinvestigated.Design:OnehundredseventeenhealthyEuropeanpostmenopausalwomenparticipatedinthisrandomized,double-blind,pla...
医源资料库;在线期刊;美国临床营养学杂志;2005年82卷第6期Nod1actsasanintracellularreceptortostimulatechemokineproductionandneutrophilrecruitmentinvivo
...nse.Abbreviationsused:AcAiQ,D-Ala-Gln-octadecylester;AcMTP,MurNAc-L-Ala--D-Glu-L-Lys(stearoyl)-OH;DAP,diaminopimelicacid;GlcNAc,N-acetyl-glucosamyl;HEK,humanembryonickidney;iE-DAP,-D-glutamyl-meso-DAP;iQ-DAP,-D-glutaminyl-meso-DAP;MurNAc,N-acetyl-muramyl;PGN,peptidoglycan;TLR,Toll-likereceptor.J.Mas...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Additiveeffectsofmoderatedrinkingandobesityonserum-glutamyltransferaseactivity
...geditorialonpage1252.SeecorrespondingCMEexamonpage1448.ABSTRACTBackground:-Glutamyltransferase(GGT)isawidelyusedindexofliverinductionandamarkerofalcoholoverconsumption.ObesityhasalsobeensuggestedtoelevateserumGGTactivities.Objective:Theaimwastoexaminethelinksbetweenmoderateethanolconsumption,obesity...
医源资料库;在线期刊;美国临床营养学杂志;2006年83卷第6期DefinitionoftargetantigensfornaturallyoccurringCD4+CD25+regulatoryTcells
...omnaivemice.Thesuppressiveeffectrequiredcellularcontactandwasblockedbyanti-glucocorticoid–inducedtumornecrosisfactorreceptorfamily–relatedgeneantibody.Invitrosuppressiveactivityessentiallydisappeared8wkafterthelastimmunization.However,itwasregainedbyinvitrorestimulationwithcognateself-antigenpro...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第5期ConstitutivelyActiveMutantsoftheHistamineH1ReceptorSuggestaConservedHydrophobicAsparagine-CageThatConstrainstheActivationofClassAGProtein
...ntifiedposition6.40inTM6asa“hotspot“becausemutationofIle6.40420eithertoGlu,Gly,Ala,Arg,Lys,orSerresultedinhighlyactiveCAMH1Rs,forwhichalmostnohistamine-inducedreceptoractivationresponsecouldbedetected.Thehighlyconservedhydrophobicaminoacidatposition6.40defines,inacomputationalmodeloftheH1R,theas...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第1期