Intrarenaloctreotidetreatmentpreventssodiumretentioninlivercirrhoticrats:evidencefordirecteffectswithinthethickascendinglimbofHenle‘
...hehypothesisthatoctreotidehasadirecteffectonrenaltubularfunction.Rats(CBLorSham-CBL)wereintrarenallytreatedwithlow-doseoctreotideinalong-actingreleaseformulation,whichhadnosystemicactions(100µg/kgbodywtasasingledose).Ratsreceivinglow-doseoctreotide(sc)wereusedascontrols.Theratswerechronicallyi...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第9期MesangialcellsinitiatecompensatoryrenaltubularhypertrophyviaIL-10-inducedTGF-secretion:effectoftheimmunomodulatorAS101onthisprocess
...mmunomodulatorAS101onthisprocess.Onehundredfortyunilateralnephrectomizedandsham-operatedmaleSprague-DawleyratsweretreatedbyAS101orPBSbeforeandaftersurgery.TheresultsshowthatsecretionofIL-10andTGF-bymesangialcellsisolatedfromtheremainingkidneyswasincreasedsignificantly,comparedwiththoseofcontrolandsh...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期川芎嗪对急性出血坏死性胰腺炎肺损伤治疗机理研究
...pancreatitisinrats.MethodsOnehundred-eightWistarratswererandomlydividedintoshamoperationgroup,AHNPgroup,tetramethylpyrazinegroup.AHNPmodelwasinducedbyintraductuladministrationof5%sodiumtaurocholate.Tetramethylpyrazine(80mg/kg)wasadministratedbycaudalveininjection30minutesaftermodelinduction....
合作平台;在线期刊;中华中西医杂志;2004年第5卷第13期;论著Exercisetrainingimprovesrenalexcretoryresponsestoacutevolumeexpansioninratswithheartfailure
...icresponsestoacuteVEwereexaminedinsedentaryandExTgroupsofratswitheitherHForsham-operatedcontrols.Experimentswereperformedinanesthetized(Inactin)rats6wkaftercoronaryligationsurgery.Histologicaldataindicatedthattherewasa34.9±3.0%outerand42.5±3.2%innerinfarctofthemyocardiumintheHFgroup.Sh...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期GeneticsuppressionofHO-1exacerbatesrenaldamage:reversedbyanincreaseintheantiapoptoticsignalingpathway
...mmwasplacedaroundtheleftrenalartery.Fivegroupsofage-matchedratswerestudied:sham-operatedLXSNanimals,2K1CLXSNrats,sham-operatedLSN-RHO-1-ASanimals,2K1CLSN-RHO-1-ASrats,and2K1CLSN-RHO-1-ASratstreatedwithcobaltprotoporphyrin(CoPP)for3wk(5mg/100gbodywt,administeredsubcutaneouslyinweeklyinjections).Eachg...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第1期AngiotensinII,interstitialinflammation,andthepathogenesisofsalt-sensitivehypertension
...ndinflammatorycellsinratspreviouslyexposedtoANGIIwithorwithoutMMFtreatment.Shamcontrolswerealsoexamined.TheadministrationofANGII,followedbyexposuretohigh-saltdiet,resultedinhypertension,corticalvasoconstriction,anincreaseininterstitialinflammatorycells(44.8±1.3lymphocytes/mm2,and30.8±1...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第12期不同干预措施对大鼠体外循环后急性肺损伤的影响
...咪达唑仑+PDTC组(CPBPDTC组)、异丙酚组(CPBPROP组)和假手术组(Sham组),Sham组不实施CPB。CPBPRoP组腹腔注射异丙酚、芬太尼行麻醉诱导,其它三组腹腔注射咪达唑仑、芬太尼行麻醉诱导,CPBPDTC组转流前30min腹腔注射PDTC100mg·kg-1。CPB转流...
行业资讯;临床快报;免疫系统尼可地尔预先给药对心肌缺血再灌注兔心肌细胞凋亡的影响
...究者将雄性新西兰白兔40只,随机分为5组(n=8),假手术组(Sham组):仅穿线,不结扎;IR组:缺血30min再灌注120min;Nic组:缺血前10min静脉注射尼可地尔100μg·kg-1负荷量,随后以10μg·kg-1·min-1的速率持续静脉输注至缺血前即刻;Nic+5-H...
行业资讯;临床快报;心脑血管相关电刺激迷走神经对败血症大鼠肝脏的保护作用
...。研究者将成年雄性SD大鼠40只,随机分为4组:假手术组(SHAM组)、CLP组、迷走神经切断组(VGX组)和迷走神经刺激组(STM组),每组10只。CLP、VGX、STM组采用盲肠结扎穿孔法(CLP)建立败血症模型,VGX组CLP后行双侧颈部迷走神经干分离术,S...
行业资讯;临床快报;神经科脊髓损伤继发骨质疏松大鼠骨髓基质细胞OPG、RANKL基因表达特点
...周组;20只在同水平处切断棘突、椎板制作假手术对照组(sham),分为Sham6周和12周组;另20只分为正常6周和12周对照组。分别在SCI后6周和12周时取材,行骨髓基质细胞培养,并检测其成骨能力及OPG、RANKL基因表达。结果脊髓损伤6周...
行业资讯;临床快报;康复医学