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TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...usingtransgenesisofbacterialartificialchromosomes(BAC)ingeneticallysusceptiblemice.PhenotypicandgeneticcharacterizationofthetransgenicanimalstracedtheresistancegenetoasingleregionspanningtheLy49hgene.TheappearanceoftheLy49HproteininNKcellsoftransgenicmicecoincidedwiththeemergenceofMCMVresistance,and...
医源资料库；在线期刊；实验医学杂志；2003年第197卷第3期 -
ConditionalKnockoutofMacrophagePPARIncreasesAtherosclerosisinC57BL/6andLow-DensityLipoproteinReceptor–DeficientMice
...genesisinvivo,wegeneratedmacrophage-specificPPARknockout(MacPPARKO)mice.C57BL/6andlow-densitylipoprotein(LDL)receptor–deficient(LDLR–/–)micewerereconstitutedwithMacPPARKOorwild-typemarrowandchallengedwithanatherogenicdiet.NodifferenceswerefoundinserumlipidsbetweenrecipientsreconstitutedwithMac...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2005年第25卷第8期 -
Angiopoietin-LikeProtein3RegulatesPlasmaHDLCholesterolThroughSuppressionofEndothelialLipase
...eactivityofendogenousELiselevatedinAngptl3-deficientmice.Furthermore,weestablishedanELISAsystemforhumanANGPTL3andfoundthatplasmaANGPTL3levelssignificantlycorrelatedwithplasmaHDLcholesterolandHDL-PLlevelsinhumansubjects.Conclusions-Angptl3actsasaninhibitorofELandmaybeinvolvedintheregulationofplasmaHD...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第2期 -
UncouplingProteinHasProtectiveFunctionduringExperimentalAutoimmuneEncephalomyelitis
...talautoimmuneencephalomyelitis,amurinemodelofmultiplesclerosis.ImmunizedC57BL/6JUCP2-deficientmiceshowedaslightlydelayedonsetduringexperimentalautoimmuneencephalomyelitis(13.0??0.6versus11.5??0.8inwild-typecontrols)anddevelopedsignificantlyhigherdiseasescoresthanlittermatecontrols(maximumdiseasescor...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第5期 -
未成熟树突细胞诱导同种免疫低应答性的研究
...胞的应答能力。结果：在初次MLR试验中，Balb/cT细胞对C57BL/6小鼠未成熟DC刺激只呈现出微弱的增殖反应，SI=2.84±0.60，明显低于对相应品系鼠成熟DC或脾细胞的增殖反应(SI分别为15.72±6.49，6.57±2.85)；在再次MLR系统中，经未成熟DC预...
合作平台；医学论文；临床医学与专科论文；检验医学 -
天然调节性CD25+T细胞在缺乏免疫抑制的情况下对同种异体移植物的重要影响
...天然CD25+Treg细胞耗竭。他们还评估了天然CD25+Treg细胞对C57BL/6受者小鼠体内MHCⅡ错配（C57BL/6xbm12）F1皮肤或bm12心脏移植物的影响。最后，他们研究了天然CD25+Treg细胞对混合淋巴细胞培养中辅助性T细胞（Th）1和Th2细胞因子生成的影...
行业资讯；临床快报；免疫系统 -
EffectofAging,MnSODDeficiency,andGeneticBackgroundonEndothelialFunction
...ndash;mice,respectively).TheendothelialdysfunctionwassimilarinmiceonbothC57BL/6andCD-1geneticbackgrounds.IncontrasttoACh,responsestotheendothelium-independentdilatorsodiumnitroprussidewereenhancedinoldMnSOD+/+andMnSOD+/–micecomparedwithbothgroupsofyoungmice(P0.05).Superoxidelevels,asmeasuredus...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第9期 -
TransgenicExpressionoftheActivatingNaturalKillerReceptorLy49HConfersResistancetoCytomegalovirusinGeneticallySusceptibleMice
...usingtransgenesisofbacterialartificialchromosomes(BAC)ingeneticallysusceptiblemice.PhenotypicandgeneticcharacterizationofthetransgenicanimalstracedtheresistancegenetoasingleregionspanningtheLy49hgene.TheappearanceoftheLy49HproteininNKcellsoftransgenicmicecoincidedwiththeemergenceofMCMVresistance,and...
医源资料库；在线期刊；美国病理学杂志；2003年第162卷第3期 -
二、选用遗传背景明确，具有已知菌丛和模型性状显著且隐定的动物
...C3H、A、DBA、bIII、BALB/C、C57BR、C57W肺 癌A、SWR、BALB/C、BL肝细胞瘤C3H、C3H2、C3He白血病及其它网状细胞瘤C58、AKR、C57L、BALB/C、DBA/2皮肤乳头状瘤及癌HR、I哈德氏腺癌C3H皮下肉瘤CBA、C3H胃癌I、BRS、C3H、C57BL/C肾上腺皮脂瘤CE、NH、BA...
医源资料库；医源图书馆；教材类；医用实验动物学 -
热疗羟基喜树碱放疗综合治疗对荷Lewis肺癌的C57BL小鼠的作用
...疗、羟基喜树碱（HCPT）及放疗联合应用对荷Lewis肺癌的C57BL小鼠的抗肿瘤作用。方法采用肿瘤生长延迟（TGD）分析热、化、放联合应用对荷Lewis肺癌的C57BL小鼠的抗肿瘤作用。结果（1）41℃、42℃、43℃热疗的TGD分别为1.07、1.40、2.5...
合作平台；在线期刊；中华中西医杂志；2004年第5卷第19期；论著