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Notch1modulatestimingofG1-SprogressionbyinducingSKP2transcriptionandp27Kip1degradation
...Sci.USA.97:10820–10825.Berezovska,O.,C.Jack,P.McLean,J.C.Aster,C.Hicks,W.Xia,M.S.Wolfe,W.T.Kimberly,G.Weinmaster,D.J.Selkoe,andB.T.Hyman.2000.Aspartatemutationsinpresenilinandgamma-secretaseinhibitorsbothimpairnotch1proteolysisandnucleartranslocationwithrelativepreservationofnotch1signaling.J.Neur...
医源资料库；在线期刊；实验医学杂志；2005年第202卷第1期 -
EnhancedBCellExpansionSurvivalandHumoralResponsesbyTargetingDeathReceptor6
...utoimmunemanifestations.J.Exp.Med.190:1697–1710.Khare,S.D.,I.Sarosi,X.-Z.Xia,S.McCabe,K.Miner,I.Solovyev,N.Hawkins,M.Kelley,D.Chang,G.Van,etal.2000.SevereBcellhyperplasiaandautoimmunediseaseinTALL-1transgenicmice.Proc.Natl.Acad.Sci.USA.97:3370–3375.Schiemann,B.,J.L.Gommerman,K.Vora,T.G.Cachero,S...
医源资料库；在线期刊；美国病理学杂志；2003年第162卷第1期 -
ExpressionofProteinKinaseCKinAstroglialCellsofNormalandNeovascularizedRetina
...giogenesis.6Theinitialstimulusforretinalneovascularizationisthoughttobehypoxiaorischemiathatcausesincreasesintheexpressionofgrowthfactors,integrins,andproteinasesresultingintheformationofnewvessels.Thefirstreactiontohypoxiaisstimulationofhypoxia-induciblefactor-1,whichup-regulatesangiogenicfactorssu...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第5期 -
EnhancedBCellExpansion,Survival,andHumoralResponsesbyTargetingDeathReceptor6
...utoimmunemanifestations.J.Exp.Med.190:1697–1710.Khare,S.D.,I.Sarosi,X.-Z.Xia,S.McCabe,K.Miner,I.Solovyev,N.Hawkins,M.Kelley,D.Chang,G.Van,etal.2000.SevereBcellhyperplasiaandautoimmunediseaseinTALL-1transgenicmice.Proc.Natl.Acad.Sci.USA.97:3370–3375.Schiemann,B.,J.L.Gommerman,K.Vora,T.G.Cachero,S...
医源资料库；在线期刊；实验医学杂志；2003年第197卷第1期 -
Hypoxia-induciblefactorsinthekidney
【摘要】Tissuehypoxianotonlyoccursunderpathologicalconditionsbutisalsoanimportantmicroenvironmentalfactorthatiscriticalfornormalembryonicdevelopment.Hypoxia-induciblefactorsHIF-1andHIF-2areoxygen-sensitivebasichelix-loop-helixtranscriptionfactors,whichregulatebiologicalprocessesthatfacilitatebot...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第8期 -
SUMOylationAttenuatesSensitivitytowardHypoxia-orDesferroxamine-InducedInjurybyModulatingAdaptiveResponsesinSalivaryEpithelialCells
...lityofratsalivaryPa-4epithelialcellstoresistcellinjuryelicitedby1%O2-orhypoxia-mimeticdesferroxamine(DFO)-stimulatedSUMOylationprocesses.ByusingPa-4cellsstablytransducedwithlenti-SUMO-1andacell-permeantpeptideharboringSUMO-bindingmotiftointerferewithSUMO-dependentprotein-proteininteractions,wedemons...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第5期 -
ATPandpurinergicreceptor–dependentmembranetrafficinbladderumbrellacells
...TP.J.Neurosci.21::5670-5677.Cockayne,D.A.etal.2000..Urinarybladderhyporeflexiaandreducedpain-relatedbehaviourinP2X3-deficientmice.Nature.407::1011-1015.Ferguson,D.R.,Kennedy,I.,andBurton,T.J.1997..ATPisreleasedfromrabbiturinarybladderepithelialcellsbyhydrostaticpressurechanges—apossiblesensorymech...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第9期 -
Treatmentofprotein-energymalnutritioninchronicnonmalignantdisorders
...respondingtonutritionalsupplementationwerecharacterizedbyincreasedage,anorexia,andanelevatedinflammatorysystemicresponse(41).Insummary,nutritionaltreatmentofPEMinconnectionwithCOPDmaypositivelyaffectbodycompositionaswellasmuscularstrengthandrespiratoryfunction.Viewthistable:TABLE1..Nutritionaltreatm...
医源资料库；在线期刊；美国临床营养学杂志；2001年74卷第1期 -
Erythropoietinandthecardiorenalsyndrome:cellularmechanismsonthecardiorenalconnectors
...tionsrangingfrom3to15U/l(140).TheprimarystimulusofEpoproductionistissuehypoxia,whichactivateshypoxia-induciblefactor-1(HIF-1),whichinturninducestranscriptionoftheEpogene.TheincreaseinEpomRNAreachesitsmaximumat4-8hafterexposuretohypoxia,followingthetimecourseofHIF-1activation.Themechanismresponsiblef...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第11期 -
CerebralIschemia-HypoxiaInducesIntravascularCoagulationandAutophagy
【摘要】Hypoxiaisacriticalfactorforcelldeathorsurvivalinischemicstroke,butthepathologicalconsequencesofcombinedischemia-hypoxiaarenotfullyunderstood.HereweexaminethisissueusingamodifiedLevine/Vannucciprocedureinadultmicethatconsistsofunilateralcommoncarotidarteryocclusionandhypoxiawithtightlyreg...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第8期