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cIAP2isaubiquitinproteinligaseforBCL10andisdysregulatedinmucosa-associatedlymphoidtissuelymphomas
...tagonizingIAPproteins.Cell.102::43-53.Srinivasula,S.M.etal.2001..AconservedXIAP-interactionmotifincaspase-9andSmac/DIABLOregulatescaspaseactivityandapoptosis.Nature.410::112-116.Yang,Y.,Fang,S.,Jensen,J.P.,Weissman,A.M.,andAshwell,J.D.2000..UbiquitinproteinligaseactivityofIAPsandtheirdegradationinpr...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第1期 -
TargetedablationofIKK2improvesskeletalmusclestrength,maintainsmass,andpromotesregeneration
...oftenasecondaryconsequenceofotherpathologicalstates.Forexample,cardiaccachexialeadstoprogressivemuscleatrophy,whichhasbeenincreasinglyappreciatedasapowerfulnegativepredictivefactorinheartfailure(2,3).Moreover,mostcancerpatientssufferfrommuscledegeneration(4),whichalsooccursinpatientswithdysfunctiono...
医源资料库；在线期刊；临床研究杂志；2006年第116卷第11期 -
InvolvementofFoxotranscriptionfactorsinangiogenesisandpostnatalneovascularization
...lesofthegeneencodingforkheadtranscriptionfactorFoxo1.Nat.Genet.32::245-253.Xia,S.J.,Pressey,J.G.,andBarr,F.G.2002..Molecularpathogenesisofrhabdomyosarcoma.CancerBiol.Ther.1::97-104.Hu,M.C.etal.2004..IkappaBkinasepromotestumorigenesisthroughinhibitionofforkheadFOXO3a.Cell.117::225-237.Brunet,A.etal.1...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第9期 -
RegulationofTypeIICollagenSynthesisduringOsteoarthritisbyProlyl--Hydroxylases
...ocytesto1%oxygenenhancedaccumulationofnativetypeIIcollagenandstabilizedhypoxia-induciblefactor-1(HIF-1).ThiseffectwasabolishedbyadditionoftheHIF-1inhibitor2-methoxyestradiol.Real-timepolymerasechainreactionanalysesofmRNAsfromtheseculturesrevealedincreasedtranscriptlevelsofboth-subunitsofprolyl-4-hyd...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第8期 -
Plateletssecretestromalcell–derivedfactor1andrecruitbonemarrow–derivedprogenitorcellstoarterialthrombiinvivo
...lone:9C10),anti-CD162(PSGL-1,clone:2PH1)(allfromBectonDickinson),anti-GPIb(Xia.B2,Emfret)oranti-GPVImAb(2G3,generatedasdescribed(22)),orirrelevantisotype-matchedcontrolantibodyfor30minatroomtemperatureanddirectlyanalyzedonaFACSCalibur(BectonDickinson).Inaseparatesetofexperiments,CD34+orKSLBM-PCs(2x1...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第5期 -
Survivaladvantagesofobesityindialysispatients
...).Davosetal(65)examinedtheeffectofBMIin589patientswithCHFwhodidnothavecachexia,asdefinedbyaweightloss7.5%over6mo.Afterthepatientsweredividedinto5equallysizedquintiles(Q1toQ5),survivalwassignificantlybetterinmildlytomoderatelyobesepatients(Q4)butnotinmostobesepatients(Q5).However,inmultivariateanalys...
医源资料库；在线期刊；美国临床营养学杂志；2005年81卷第3期 -
HemeOxygenase-1
...hatCOmayberesponsibleforregulatingsmoothmusclecelltoneunderconditionsofhypoxia(62).Significantdifferencesalsoexistbetweenthetwogaseousenzymaticproducts.NO,withitsunpairedelectron,isafreeradicalcapableofundergoingvariousoxidativeandreductivereactions,whereasCOisrelativelyinert.Thesimilaritiesanddiffe...
医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第9期 -
肺阳概念内涵、外延的厘定及肺阳虚
...on,ExtensionoftheConceptofLung-yangandDeficiencyofLung-yangZhangHong1,ZhangXiao-xia2,LiFei1，LiuLiang3(FirstAffiliatedHospital，ChengduMedicalCollege，1.DepartmentofRehabilitationMedicine；2.DepartmentofGynaecologyandObstetrics；3.DepartmentofTCMChengdu610500，China.)Abstract：Theconnotationo...
医源资料库；在线期刊；成都医学院学报；2006年第1卷第1期 -
Oxidantstressfromnitricoxidesynthase–3uncouplingstimulatescardiacpathologicremodelingfromchronicpressureload
...aseduringprogressionofcardiachypertrophytofailure.Hypertension.40::477-484.Xiao,L.etal.2002..RoleofreactiveoxygenspeciesandNAD(P)Hoxidaseinalpha(1)-adrenoceptorsignalinginadultratcardiacmyocytes.Am.J.Physiol.CellPhysiol.282::C926-C934.Saavedra,W.F.etal.2002..Imbalancebetweenxanthineoxidaseandnitrico...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第5期 -
ClostridiumsordelliiLethalToxinKillsMicebyInducingaMajorIncreaseinLungVascularPermeability
...ratedprofoundmodificationssuchasanimaldehydration,increaseinhematocrit,hypoxia,andfinally,cardiorespiratoryfailure.Vascularpermeabilityincreaseinducedbylethaltoxinresultedfrommodificationsoflungendothelialcellsasevidencedbyelectronmicroscopy.ImmunohistochemicalanalysisdemonstratedthatVE-cadherin,apr...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第3期