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ContributionofDNApolymerasetoimmunoglobulingenehypermutationinthemouse
...sitéParisV,75730ParisCedex15,FranceThemutationpatternofimmunoglobulingeneswasstudiedinmicedeficientforDNApolymerase,atranslesionalpolymerasewhoseinactivationisresponsibleforthexerodermapigmentosumvariant(XP-V)syndromeinhumans.Mutationsshowan85%G/Cbiasedpattern,similartothatreportedforXP-Vpatients.B...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第8期 -
UseoftheMGBEclipseSystemandSmartCyclerPCRforDifferentiationofMycobacteriumchelonaeandM.abscessus
...eforClinicalandExperimentalPathology,SaltLakeCity,UtahNanogen,Inc.,Bothell,WashingtonARUPLaboratories,SaltLakeCity,UtahUniversityofTexasHealthCenter,Tyler,TexasUniversityofUtah,DepartmentofPathology,SaltLakeCity,UtahABSTRACTAlthoughaccurateintheidentificationofMycobacteriumspecies,partial16SrRNAgene...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第8期 -
SelectivedysregulationoftheFcIIBreceptoronmemoryBcellsinSLE
1DepartmentofMedicine,ColumbiaUniversityMedicalCenter,NewYork,NY100322DepartmentofMedicine,AlbertEinsteinCollegeofMedicine,Bronx,NY104613MacroGenicsInc.,Rockville,MD208504TheRockefellerUniversity,NewYork,NY10021TheinappropriateexpansionandactivationofautoreactivememoryBcellsandplasmablastscontribute...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第9期 -
SpecificandSensitiveDetectionofNeisseriagonorrhoeaeinClinicalSpecimensbyReal-TimePCR
...etherlandsABSTRACTEarlydiagnosisofNeisseriagonorrhoeaeinfectionsisimportantwithregardtopatients‘healthandinfectivity.WereportthedevelopmentofaspecificandsensitiveTaqManassayforthedetectionofN.gonorrhoeaeinclinicalsamples.Thetargetsequenceisa76-bpfragmentofthe5‘untranslatedregionoftheopagenesthat...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第11期 -
PreclinicalDiagnosisofAfricanSwineFeverinContact-ExposedSwinebyaReal-TimePCRAssay
...Center,AgriculturalResearchService,U.S.DepartmentofAgriculture,Greenport,NewYorkDepartmentofPathobiology,UniversityofConnecticut,Storrs,ConnecticutTetracoreInc.,Gaithersburg,MarylandABSTRACTAfluorogenicprobehydrolysis(TaqMan)PCRassayforAfricanswinefevervirus(ASFV)wasdevelopedandevaluatedinexperiment...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第1期 -
Conditionaldeletionrevealsacell-autonomousrequirementofSLP-76forthymocyteselection
...ennsylvaniaSchoolofMedicine,Philadelphia,PA191044DepartmentofImmunology,RoswellParkCancerInstitute,Buffalo,NY14263TheSH2domaincontainingleukocytephosphoproteinof76kD(SLP-76)iscriticalforpre-TCR–mediatedmaturationtotheCD4+CD8+doublepositive(DP)stageinthethymus.TheabsoluteblockinSLP-76nullmiceattheC...
医源资料库；在线期刊；实验医学杂志；2005年第202卷第7期 -
AscariasisIsaZoonosisinDenmark
...angladeshABSTRACTApreliminaryepidemiologicalsurveyindicatedanassociationbetweenAscarisinfectionsinDanishpatientsandcontactwithpigsorpigmanure.Inthepresentstudy,wecomparedAscariswormscollectedfromhumansandAscariswormscollectedfrompigsbyamplifiedfragmentlengthpolymorphism(AFLP)analysis,atechniqueforwh...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第3期 -
ComparisonofSpecimenProcessingandNucleicAcidExtractionbytheSwabExtractionTubeSystemversustheMagNAPureLCSystemforLaboratoryDiagnosisofH
...ine,Rochester,MinnesotaABSTRACTAtotalof563specimens(234dermaland329genitalswabs)frompatientssuspectedofhavingherpessimplexvirus(HSV)infectionswereprocessedusingtwodifferentextractionmethods(theMagNAPureLCsystemandtheswabextractiontubesystem[SETS]);HSVDNAwasamplifiedbyLightCyclerPCR.HSVDNAwasdetected...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第3期 -
ThePimkinasescontrolrapamycin-resistantTcellsurvivalandactivation
...iladelphia,PA19104AlthoughPim-1orPim-2cancontributetolymphoidtransformationwhenoverexpressed,thephysiologicroleofthesekinasesintheimmuneresponseisuncertain.WenowreportthatTcellsfromPim-1–/–Pim-2–/–animalsdisplayanunexpectedsensitivitytotheimmunosuppressantrapamycin.Cytokine-inducedPim-1andPi...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第2期 -
PathologyandprotectioninnephrotoxicnephritisisdeterminedbyselectiveengagementofspecificFcreceptors
1LaboratoryofMolecularGeneticsandImmunology,TheRockefellerUniversity,NewYork,NY100212RenalElectrolyteandHypertensionDivision,TheUniversityofPennsylvania,Philadelphia,PA19104Introductionofheterologousanti–glomerularbasementmembraneantiserum(nephrotoxicserum,NTS)intopresensitizedmicetriggerstheprodu...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第3期