PhosphataseandTensinHomologDeletedonChromosome10(PTEN)ReducesVascularEndothelialGrowthFactorExpressioninAllergen-InducedAirwayInflammation
...ndtensinhomologdeletedonchromosome10(PTEN)hasbeenimplicatedinregulatingcellsurvivalsignalingthroughthephosphoinositide3-kinase(PI3K)/Aktpathway.ThekeyroleofPI3KinVEGF-mediatedsignaltransductionisestablished.However,theeffectsofPTENonVEGF-mediatedsignalinginasthmaareunknown.Thisstudyaimedtodeterminet...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第6期Saturatedfat–richdietenhancesselectiveuptakeofLDLcholesterylestersinthearterialwall
...sand2DepartmentofPathology,InstituteofHumanNutrition,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NewYork,USA.AbstractPlasmaLDLlevelsandatherosclerosisbothincreaseonasaturatedfat–rich(SAT)diet.LDLcholesteroldeliverytotissuemayoccurviauptakeoftheLDLparticlesorviaselectiveuptake(SU),whe...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第8期联合应用降糖药治疗2型糖尿病疗效分析
...。1.2方法59例2型DM,在饮食控制下,接受单一磺酰脲类(SU)或单一中、草药降糖药治疗达半年以上,空腹血糖仍≥9.0mmol/L,餐后2h血糖≥11.1mmol/L,HbA1c7%者,随机分为三组:第一组19例:瑞易宁(辉瑞制药有限公司)10mg,每日1次口...
医源资料库;在线期刊;中华实用医药杂志;2005年第5卷第16期甘精胰岛素联合瑞格列奈治疗2型糖尿病患者24h动态血糖变化
...项指数比较注:与治疗前比较,P<0013讨论 磺脲类(SU)继发性失效是2型糖尿病治疗中的常见问题。随着胰岛B细胞功能以每年10%的速度下降,SU继发性失效的患者增加,改善胰岛素细胞功能是恢复患者对口服药物敏感性的基...
医源资料库;在线期刊;中华现代临床医学杂志;2008年第6卷第10期OSU-03012PromotesCaspase-IndependentbutPERK-,CathepsinB-,BID-,andAIF-DependentKillingofTransformedCells
...5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl}acetamide(OSU-03012)killedprimaryhumangliomaandothertransformedcells.OSU-03012causedadose-dependentinductionofcelldeaththatwasnotalteredbyp53mutation,expressionofERBB1vIII,orlossofphosphataseandtensinhomologdeletedonchromosome10function...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期Fish-oilestersofplantsterolsimprovethelipidprofileofdyslipidemicsubjectsmorethandofish-oilorsunfloweroilestersofplantsterols
...-de-Bellevue,Canada(ID,Y-MC,andPJ),andEnzymotecLtd,MigdalHaEmeq,Israel(DP)2SupportedbyaPost-DoctoralIndustrialResearchFellowshipfromtheNaturalSciencesandEngineeringResearchCouncilofCanada(toID)andbyEnzymotecLtd(MigdalHaEmeq,Israel).MargarinescontainingsunfloweroilestersofplantsterolsweredonatedbyUni...
医源资料库;在线期刊;美国临床营养学杂志;2006年84卷第6期LowConcentrationsofNitricOxideExertaHormeticEffectonMycobacteriumtuberculosisInVitro
...partmentofClinicalLaboratorySciences,NewOrleans,Louisiana70112-2223ABSTRACTSusceptibilitiesof12clinicalMycobacteriumtuberculosisisolatestoacidifiedsodiumnitrite(ASN)werecompared.Theresultsdemonstratethat8ofthe12isolatesexhibitedenhancedsurvivallevelsin1.5mMASNcomparedtolevelsinmediumalone,suggesting...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期胸腔内注射沙培林和顺铂治疗肺癌合并胸腔积液
...ibznilandCDDP;inthecontrolgroup,WeonlyinjectCDDPintothepleuralcavity.ReˉsultsTheresponserateoftreatmentgroupis86.9%,theresponserateofcontrolgroupis56.52%,combinedtheraˉpywithpicibznilandCDDPwassuperiortosingledrugofCDDPinpatientswithmalignantpleuraleffusion.ConcluˉsionThecombinedtherapywith...
合作平台;在线期刊;中华中西医杂志;2004年第5卷第17期;论著DetectionofSevereAcuteRespiratorySyndromeCoronavirusRNAinPlasmaduringtheCourseofInfection
...eforeday11,togetherwiththerelativeconvenienceofcollectingandhandlingplasma,suggestthatplasmacanbeusedforearlydiagnosisofSARS.TEXTSevereacuterespiratorysyndrome(SARS)isanemerginginfectiousdiseasethatposesapotentialthreattothehealthofpeoplethroughouttheworld(10,16).Theetiologicalagentisanovelcoronavir...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第2期TempolreducesoxidativestressandrestoresrenaldopamineD1-likereceptor-Gproteincouplingandfunctioninhyperglycemicrats
...frenalD1-likereceptorsinhibitstheactivitiesofNa-K-ATPaseandNa/Hexchangerandsubsequentlyincreasessodiumexcretion.Decreasedrenaldopamineproductionandsodiumexcretionareassociatedwithhyperglycemicconditions.WehaveearlierreportedD1-likereceptor-GproteinuncouplingandreducedresponsetoD1-likereceptoractivat...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第7期