Entryofparainfluenzavirusintocellsasatargetforinterruptingchildhoodrespiratorydisease
DepartmentofPediatricsandDepartmentofMicrobiologyandImmunology,WeillMedicalCollegeofCornellUniversity,NewYork,NewYork,USA.AbstractHumanparainfluenzavirusescauseseveralseriousrespiratorydiseasesinchildrenforwhichthereisnoeffectivepreventionortherapy.Parainfluenzavirusesinitiateinfectionbybindingtocel...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期MolecularEvolutionofHumanInfluenzaA/H3N2VirusinAsiaandEuropefrom2001to2003
AppliedImmunologyandMicrobiologyDivision,WyethVaccinesResearch,PearlRiver,NewYork10965ABSTRACTHemagglutininsequencesof146humaninfluenzaA/H3N2strainsidentifiedinrespiratoryspecimensfromAsiaandEuropeduringthe2001-2003influenzaseasonswereanalyzedbyDNAsequencing.Ourresultssuggestthatfouraminoacidsubstit...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期High-DensityLipoproteinPromotesEndothelialCellMigrationandReendothelializationviaScavengerReceptor-BTypeI
...rationinvitroinanitricoxide-independentmannerviascavengerreceptorBtypeI(SR-BI)-mediatedactivationofRacGTPase.ThisprocessdoesnotrequireHDLcargomolecules,anditisdependentontheactivationofSrckinases,phosphatidylinositol3-kinase,andp44/42mitogen-activatedproteinkinases.Rapidinitialstimulationoflamellipo...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第1期Removalofhomeostaticcytokinesinksbylymphodepletionenhancestheefficacyofadoptivelytransferredtumor-specificCD8+Tcells
...gmentingtheactivityofself/tumor-reactiveCD8+Tcells.Thus,therestrictedavailabilityofhomeostaticcytokinescanbeacontributingfactortoperipheraltolerance,aswellasalimitingresourcefortheeffectivenessoftumor-specificTcells.L.Gattinoni,S.E.Finkelstein,andC.A.Klebanoffcontributedequallytothiswork.Theimmunesy...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第7期Corynebacteriumresistenssp.nov.,aNewMultidrug-ResistantCoryneformBacteriumIsolatedfromHumanInfections
...abscessspecimens.Fourofthefivestrainsisolatedwerehighlyresistanttoantimicrobialagents,including-lactams,aminoglycosides,macrolides,quinolones,andtetracyclines,exceptforglycopeptides.Inimmunocompromisedpatients,bacteremiaassociatedwiththisorganismwasrapidlyfatal.Thiscoryneformbacteriumwasnonmotile,li...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第8期四、近交系小鼠和大鼠中自发性肿瘤的发病率
...90%;C3H/HeJ80~100%,C3H/HeN繁殖鼠和处雌鼠中接近100%。C3H/Bi生产雌鼠85~90%。 (3)DBA系小鼠:DBA/1经产母鼠61.5~75%。DBA/250~60%。 (4)DD系小鼠:生产雌鼠63%,7.7月龄生产雌鼠84%。 (5)FM系小鼠:生产雌鼠90%以上。 ...
医源资料库;医源图书馆;教材类;医用实验动物学Piliprovepertinenttoenterococcalendocarditis
DepartmentofMicrobiology,UniversityofChicago,Chicago,Illinois,USA.AbstractEnterococcusfaecalisisanimportantagentofendocarditisandurinarytractinfections,whichoccurfrequentlyinhospitals.Antimicrobialtherapyiscomplicatedbytheemergenceofdrug-resistantstrains,whichcontributesignificantlytomortalityassoci...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第10期Antiviraldefense:interferonsandbeyond
...alresponse.D.B.S.andR.M.areatHowardHughesMedicalInstituteandSectionofImmunobiology,YaleUniversitySchoolofMedicine,NewHaven,CT06520.Virusesarethemostabundantpathogensonearth,andthesurvivalofmanyorganismsdependsontheirabilitytosenseandrestrictviralinfection.Detectionofnucleicacidsisafundamentalmeansof...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第8期ComparisonoftheNationalInstitutesofHealthStrokeScaleWithDisabilityOutcomeMeasuresinAcuteStrokeTrials
...diovascularandMedicalSciences(F.B.Y.,C.J.W.,K.R.L.)andtheRobertsonCentreforBiostatistics(C.J.W.),UniversityofGlasgow,Glasgow,U.K.AbstractBackgroundandPurpose—Acutestroketrialstypicallyusedisabilityscalesastheirprimaryendpoint.NeurologicimpairmentscalessuchastheNationalInstitutesofHealthStrokeScale...
医源资料库;在线期刊;中风学杂志;2005年第36卷第10期Goingnuclearinmetabolicandcardiovasculardisease
...orsthatregulatediverseaspectsofdevelopmentandhomeostasis.Recentstudiesofthebiologicrolesofthesereceptorsandtheirmechanismsofactionhavesignificantlyadvancedourunderstandingoftranscriptionalprogramsthatcontrollipidandcarbohydratemetabolism,immunityandinflammation,andwoundrepair.Thesefindingsprovideins...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第3期