Similarchloridechannelsintheconnectingtubuleandcorticalcollectingductofthemousekidney
【摘要】Usingthepatch-clamptechnique,weinvestigatedCl-channelsonthebasolateralmembraneoftheconnectingtubule(CNT)andcorticalcollectingduct(CCD).Wefounda10-pSchannelinCNTcell-attachedpatches.SubstitutionofsodiumgluconateforNaClinthepipetteshiftedthereversalpotentialby+25mV,whereasN-methyl-D-glucon...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第6期Characterizationofbasolateralchloride/bicarbonateexchangeinmaculadensacells
...teofAnatomy,UniversityofAarhus,AarhusC,DenmarkInstituteofHumanPhysiologyandClinicalExperimentalResearch,SemmelweisUniversity,Budapest,HungaryDepartmentofPhysiologyandBiophysicsandZilkhaNeurogeneticInstitute,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,CaliforniaABSTRACTFunctionalan...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第2期TheCl-/HCO3-exchangerpendrinintheratkidneyisregulatedinresponsetochronicalterationsinchloridebalance
...要】Pendrin(Pds;Slc26A4)isanewanionexchangerthatisbelievedtomediateapicalCl-/HCO3-exchangeintypeBandnon-A-non-Bintercalatedcellsoftheconnectingtubuleandcorticalcollectingduct.Recently,ithasbeenproposedthatthistransportermaybeinvolvedinNaClbalanceandbloodpressureregulationinadditiontoitsparticipati...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第12期第五章 体液平衡紊乱--第一节 体液平衡及调节
...形式摄入氯和钠,成人每日需要量5-9g,一般是摄入体内NaCL的量大于其需要量,所以,一般情况下,人体不会缺钠缺氯。 Na+、CL-主要从肾排出,肾排钠量与食入量保持平衡。肾对保持体内钠的含量起有很重要的作用。当无...
医源资料库;医源图书馆;教材类;临床生物化学原代大鼠IV型螺旋韧带结缔组织细胞ClC-2和CIC-K2氯通道的识别
...6月21日消息,原代大鼠IV型螺旋韧带结缔组织细胞中存在ClC-2和CIC-K2氯通道,调节膜离子电导。电压门控性氯化物通道(ClCs)是细胞离子含量稳定和容量调节的重要介质。在早期研究中,研究人员采用免疫组化、蛋白印记法、RT-PCR...
行业资讯;临床快报;细胞分子与蛋白质组AngiotensinIIincreaseschlorideabsorptioninthecorticalcollectingductinmicethroughapendrin-dependentmechanism
...theconnectingtubule,andthecorticalcollectingduct(CCD),whereitmediatesapicalCl-/HCO3-exchange.ThepurposeofthisstudywastodeterminewhetherangiotensinIIincreasestransepithelialnetchloridetransport,JCl,inmouseCCDthroughapendrin-dependentmechanism.JClandtransepithelialvoltage,VT,weremeasuredinCCDsperfused...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第3期异丙酚对颅内动脉瘤夹闭术时异氟烷麻醉状态下拔管的MAC的影响
...有显著性(P0.05)。A组拔管时异氟烷呼气末MAC为0.28%(95%Cl,0.25%~0.36%),95%满意浓度(ED95)为0.42%(95%Cl,0.36%~0.50%)。B组拔管时异氟烷呼气末MAC为0.55%(95%Cl,0.41%~0.62%),95%满意拔管浓度(ED95)为0.67%(95%CL0.63%~0.71%)。...
合作平台;在线期刊;中华医学实践杂志;2005年第4卷第5期;临床医学Pathophysiologyoffunctionalmutationsofthethiazide-sensitiveNa-ClcotransporterinGitelmandisease
...thathavebeendescribedinthehumanSLC12A3geneencodingthethiazide-sensitiveNa+-Cl-cotransporter(TSC,NCC,orNCCT),asthecauseofGitelmandisease,blockTSCfunctionbyinterferingwithnormalproteinprocessingandglycosylation.However,somemutationsexhibitconsiderableactivity.ToinvestigatethepathogenesisofGitelmandise...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第8期阴离子隙和潜在HCO-3诊断慢性呼吸衰竭酸碱失衡的临床意义
...)代谢性酸中毒(代酸)31例次,其中高AG代酸22例次,高Cl-代酸5例次,如不测定AG将有17例次代酸失检;(2)应用AG后,三重性酸碱失衡(TABD)从0增至14例次,在这14例次TABD中,如不应用潜在HCO-3将有8例失检。结论(1)AG和潜在...
医源资料库;在线期刊;中华现代内科学杂志;2006年第3卷第5期Applicationofβ-LactamaseEnzymeComplementationtotheHigh-ThroughputScreeningofToll-LikeReceptorSignalingInhibitors
...oll-likereceptor4(TLR4)signalinginhibitors.Wedevelopedastablecellline,HeLa/CL3-4,expressingMyD88/Bla(a)andTLR4/Bla(b),inwhichthetwoβ-lactamasefragmentscomplementwitheachotherbyvirtueofspontaneousMyD88-TLR4bindingviatheirToll/IL-1R(TIR)domains.InhibitionoftheMyD88-TLR4bindingleadstothedisruption...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期