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UridineBindingandTransportabilityDeterminantsofHumanConcentrativeNucleosideTransporters
...ifco,Detroit,MI),aminoacids(asrequiredtomaintainauxotrophicselection),and2%glucose(CMM/Glu).AgarplatescontainedCMMwithvarioussupplementsand2%agar(Difco).PlasmidswerepropagatedinE.colistrainTOP10F‘(Invitrogen,Carlsbad,CA)andmaintainedinLuriabrothwith100e/mlampicillin.DNAManipulationandPlasmidConstr...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第3期 -
DifferentialDesensitizationofHomozygousHaplotypesofthe2-AdrenergicReceptorinLymphocytes
...(position19[Cys/Arg]ofthe5‘leadercistronandpositions16[Arg/Gly]and27[Gln/Glu]ofthereceptor)forputativedifferencesinagonist-induceddesensitization.Lymphocytesofwelldefinednonasthmatic,nonallergicsubjectshomozygousforthehaplotypeCysGlyGln,ArgGlyGlu,orCysArgGlnwereisolated.Desensitizationof(eC)-isopr...
医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第8期 -
预防龋齿的新DNA疫苗的构建
...有两个重要的致病因子：细胞表面蛋白PAc和糖基转移酶（glucosyltransferases，GTFs）。GTFs有两个功能域：N-末端催化蔗糖结合域（CAT）和C-末端葡聚糖结合域（glucan-bindingdomain，GLU）。来自中国的研究人员日前构建了防龋的DNA疫苗，pG...
行业资讯；临床快报；遗传与基因组 -
ProteinKinaseC-DependentMitochondrialTranslocationofProapoptoticProteinBaxonActivationofInducibleNitric-OxideSynthaseinRostralVentrolateralM
...(Sigma-Aldrich);cellmembrane-permeableBaxinhibitorpeptides,Pro-Met-Leu-Lys-Glu(P5;TocrisCookson)orVal-Pro-Met-Leu-Lys(V5;TocrisCookson);aBaxchannelinhibitor(BCI),3,6-dibromo--(1-piperazinylmethyl)-9H-carbazole-9-ethanoldihydrochloride(TocrisCookson);aninhibitoryligandofthemitochondrialANT,bongkrekic...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第4期 -
北京大学生物化学试题（硕士）1999年,1997年,1996年,1992年,1991年,1989年,1988年
...。 三，问题 1，一个激素多肽链有29个氨基酸，顺序为Glu,Val,Lys,Asn,Cys,Phe,Arg,Trp,Asp,Leu,Gly , Ser, Leu, Glu, Ala,Thr,Cys,Arg,His,Met,Asp,Gln,Cys,Tyr,Pro,Gly,Glu,Glu,Lys, a,若没有二硫键存在，胰蛋白酶水解可有几个肽。 b,在PH7.5时激素净...
医源资料库；医源习题集；生物化学 -
PurineReleasefromSpinalCordMicrogliaafterElevationofCalciumbyGlutamate
...seThepropagationofCa2+wavesinanetworkofmicroglialcells,afteritsinitiationbyglutamate,ismediatedbypurinergictransmission.Inthisstudy,weinvestigatedthemechanismsbywhichglutamatereleasesATPfromculturedspinalcordmicroglia.The4-foldincreaseinATPreleasefrommicrogliainresponsetoglutamate(0.5mM)wasblockedby...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第9期 -
阿达木单抗联用甲氨蝶呤对ＲＡ疗效优于单药
...性关节炎患者(RA)，联用抗肿瘤坏死因子药阿达木单抗和甲氨蝶呤，比阿达木单抗单药治疗提供更好的结果。Diakonhjemmet医院的MarteSchrumpfHeiberg博士及其同事使用一项纵向研究的数据比较这两种方案。他们的发现发表于10月的《风湿...
行业资讯；临床快报；免疫系统 -
Agonist-,Antagonist-,andBenzodiazepine-InducedStructuralChangesinthe1Met113-Leu132RegionoftheGABAAReceptor
...at1subunitatMet113,Pro114,Asn115,Lys116,Leu117,Leu118,Arg119,Ile120,Thr121,Glu122,Asp123,Gly124,Thr125,Leu126,Leu127,Tyr128,Thr129,Met130,Arg131,andLeu132wherethenumberingreflectsthepositioninthemature1subunitproteinsequence.ThecysteinemutantsweresubclonedintopGH19forexpressioninXenopuslaevisoocytes...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第2期 -
Amino-PyrrolidineTricarboxylicAcidsGiveNewInsightintoGroupIIIMetabotropicGlutamateReceptorActivationMechanism
...】Amino-PyrrolidineLikemostclassCG-protein-coupledreceptors,metabotropicglutamate(mGlu)receptorspossessalargeextracellulardomainwhereorthostericligandsbind.Crystalstructuresrevealedthatthisdomain,calledVenusFlyTrap(VFT),adoptsaclosedoropenconformationuponagonistorantagonistbinding,respectively.Weha...
医源资料库；在线期刊；分子药理学杂志；2007年第69卷第3期 -
ExtracellularLoop3(EL3)andEL3-ProximalTransmembraneHelix7oftheMammalianTypeIandTypeIIGonadotropin-ReleasingHormone(GnRH)ReceptorsDetermin
...rmation.Furthermore,acombinatorymutation(Pro7.31-Pro7.32-Ser7.33motiftoSer-Glu-ProinEL3andLeu7.38,Leu7.43,Ala7.46,andPro7.47tothoseofratGnRHR)ingmGnRH-2exhibitedanapproximately500-foldincreasedsensitivitytoGnRH-I,indicatingthattheseresiduesarecriticalfordiscriminatingGnRH-IIfromGnRH-I.[Trp7]GnRH-Ian...
医源资料库；在线期刊；分子药理学杂志；2005年第67卷第4期