Stemcell–ness:a“magicmarker“forcancer
...asedonthehypothesisthattumorswithstemcell–likecharacteristicsarelikelytohaveapoorprognosis.Remarkably,an11-gene“expressionsignature“associatedwith“stemcell–ness“separatedpatientswithdifferentcancersintogood-andpoor-prognosisgroups.Sucha“magicmarker“would,ifvalidated,haveamajorimpacto...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第6期PropertiesofNovelInternationalDrug-ResistantPneumococcalClonesIdentifiedinDay-CareCentersofLisbon,Portugal
...sequencetypesthatmatchedordifferedatasingleordoublelocusfromallelicprofilesavailableintheMLSTdatabase.Theseninecloneswereofserotypes33F,10A,19A,19F,6A,20,24F,and3,onewasnontypeable,and,byMLST,theywerefoundtobeidenticalorhighlyrelatedtoisolatesfromdiseaseoriginthatweredispersedinternationally.Sinceth...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第9期Low-Voltage-Activated(T-Type)CalciumChannelsControlProliferationofHumanPulmonaryArteryMyocytes
...ionofthecellcyclemachinery,theprocessesthatregulateCa2+influxinthiscontexthavenotbeenfullyelucidated.ElectrophysiologicalandmolecularstudieshaveidentifiedmultipleCa2+channelgenesexpressedinmammaliancells.Cav3.xgenefamilymembers,encodinglowvoltage-activated(LVA)orT-typechannels,werefirstidentifiedint...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第4期CD28costimulatorysignalinducesproteinargininemethylationinTcells
...thyltransferaseactivityandmethylationonarginineofseveralproteins,includingVav1.MethylationofVav1andIL-2productionwerereducedbyinhibitingS-adenosyl-L-homocysteinehydrolase,anenzymethatregulatescellulartransmethylation.MethylatedVav1wasinducedinhumanandmouseTcellsandselectivelylocalizedinthenucleus,wh...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第3期连续性血液净化治疗重症低钠血症12例
...用利尿剂,否则难以升高血Na+,因此在肾功能不全,肾病综合征浮肿严重及利尿反应较差时血Na+难以纠正,还会引起其他电解质紊乱;(3)输入过多液体,带来容量负荷过多,对已经有液体潴留,心功能不全,高血压患者可导...
医源资料库;在线期刊;中国民康医学;2007年第19卷第21期AntihypertensiveEffectsofthePutativeT-TypeCalciumChannelAntagonistMibefradilAreMediatedbytheL-TypeCalciumChannelCav1.2
...tion,time-andtissue-specificconditionalknockoutmodeloftheL-typeCa2+channelCav1.2(Cav1.2SMAKOmice)togeneticallydissecttheeffectsofmibefradilonT-andL-typeCa2+channels.Myogenictoneandphenylephrine-inducedcontractioninhindlimbperfusionexperimentsweresensitivetomibefradilincontrolmice,whereasthedrugshowe...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第1期InhibitionofAcceleratedGraftArteriosclerosisbyGeneTransferofSolubleFibroblastGrowthFactorReceptor-1inRatAorticTransplants
...olesoftransplantedhearts,istheleadingcauseofgraftlossanddeathinpatientswhohaveundergonecardiactransplantation.1TransplantvasculopathyresemblingAGAalsooccursinrenaltransplantation,inwhichitaccounts,atleastinpart,fortheprogressivelossofgraftfunctionthatisoftenreferredtoaschronicrejection.2Fibroblastgr...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第6期SubtypeSpecificityofScorpion-ToxinTz1InteractionwithVoltage-GatedSodiumChannelsIsDeterminedbythePoreLoopofDomain3
【关键词】SubtypeSpecificityVoltage-gatedsodium(Nav)channelsaremodulatedbyavarietyofspecificneurotoxins.Scorpion-toxinsaffectthevoltage-dependenceofchannelgating:Intheirpresence,Navchannelsactivateatsubthresholdmembranevoltages.Previousmutagenesisstudieshaverevealedthatthe-toxinCss4interactswit...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期基于大鼠模型的蛛网膜下腔出血研究
...年来有关实验性大鼠蛛网膜下腔出血的实验研究的文献的综合分析,可以明确SAH是一个复杂综合的全脑性的病理损伤过程,涉及大脑大动脉、大脑微动脉以及各大脑区域脑神经元。蛛网膜下腔出血不仅造成实质性改变,也可造成...
医源资料库;在线期刊;中华医学研究杂志;2008年第8卷第7期EffectsofAllergenChallengeonAirwayEpithelialCellGeneExpression
...risonsofthedifferentialexpressionoftheseactivationmarkersinepithelialcellshaveledtoimportantadvancesinourunderstandingoftherolesofthepathwaysassociatedwiththesemarkersinasthmapathogenesis.Inadditiontorespondingtoallergensandtotheactivationofinflammatorycells,undersomecircumstances,functionalcharacte...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第3期