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Hypoxia-inducedneutrophilsurvivalismediatedbyHIF-1–dependentNF-Bactivity
...stheabilityofthesecellstoundergoapoptosis.Weexaminedthemechanismbywhichhypoxiacausesaninhibitionofneutrophilapoptosisinhumanandmurineneutrophils.Weshowthatneutrophilspossessthehypoxia-induciblefactor(HIF)-1andfactorinhibitingHIF(FIH)hydroxylaseoxygen-sensingpathwayandusingHIF-1–deficientmyeloidcel...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第1期 -
EffectoflowenvironmentalsalinityonplasmacompositionandrenalfunctionoftheAtlanticstingray,aeuryhalineelasmobranch
...re,thechangesinplasmabiochemistryandrenalfunctionmostlikelyarearesultofhypoxiaandnotanesthesiaperse(15,29,31).Toavoidproblemsassociatedwithhypoxia,weusedMS-222throughouttheexperimentataconcentrationthatinhibitedswimmingmovementsbutstillallowedsustainedmovementofthegillmusclesforadequateventilation.A...
医源资料库；在线期刊；美国生理学杂志；2006年第289卷第10期 -
IBkinase(IKK),butnotIKK,isacriticalmediatorofosteoclastsurvivalandisrequiredforinflammation-inducedboneloss
...kinesignaling.Exp.CellRes.254:14–24.Baud,V.,Z.G.Liu,B.Bennett,N.Suzuki,Y.Xia,andM.Karin.1999.Signalingbyproinflammatorycytokines:oligomerizationofTRAF2andTRAF6issufficientforJNKandIKKactivationandtargetgeneinductionviaanamino-terminaleffectordomain.GenesDev.13:1297–1308.Iotsova,V.,J.Caamano,J.Lo...
医源资料库；在线期刊；实验医学杂志；2005年第201卷第10期 -
TheBcl10–Malt1complexsegregatesFcRI-mediatednuclearfactorBactivationandcytokineproductionfrommastcelldegranulation
...c-JunN-terminalkinase.J.Biol.Chem.274:9962–9968.Sun,L.,L.Deng,C.K.Ea,Z.P.Xia,andZ.J.Chen.2004.TheTRAF6ubiquitinligaseandTAK1kinasemediateIKKactivationbyBCL10andMALT1inTlymphocytes.Mol.Cell.14:289–301.Sato,S.,H.Sanjo,K.Takeda,J.Ninomiya-Tsuji,M.Yamamoto,T.Kawai,K.Matsumoto,O.Takeuchi,andS.Akira.2...
医源资料库；在线期刊；实验医学杂志；2006年第203卷第2期 -
PreferentialAttachmentofPeritonealTumorMetastasestoOmentalImmuneAggregatesandPossibleRoleofaUniqueVascularMicroenvironmentinMetastaticSurv
...TodeterminetherelativeorientationoftheCD45+cellstotheVCAM+cells,2-µmaxialsectionsstartingabovetheaggregateanddescendingintotheunderlyinglayerofadiposetissuewereobtainedfromeachimmuneaggregate.Imagesconsistingof800x800-µmfieldsofviewwithpixelarraysof600x600fromthetwofluorescencechannelswe...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第11期 -
PKCregulatesBCR-mediatedIKKactivationbyfacilitatingtheinteractionbetweenTAK1andCARMA1
...indingtopolyubiquitinchains.Mol.Cell.15:535–548.Sun,L.,L.Deng,C.K.Ea,Z.P.Xia,andZ.J.Chen.2004.TheTRAF6ubiquitinligaseandTAK1kinasemediateIKKactivationbyBCL10andMALT1inTlymphocytes.Mol.Cell.14:289–301.Zhou,H.,I.Wertz,K.O‘Rourke,M.Ultsch,S.Seshagiri,M.Eby,W.Xiao,andV.M.Dixit.2004.Bcl10activatest...
医源资料库；在线期刊；实验医学杂志；2005年第202卷第10期 -
InflammationandCellularImmuneResponsesinAbdominalAorticAneurysms
...ns.Theintraluminalthrombusmaycontributetotheprocessbycausingafunctionalhypoxiaattheluminalintimaandinnermedia,thusinducingsubsequentneovascularizationandinflammation.11Inflammatorycellsinthethrombusalsoreleaseactiveproteasessuchasmatrixmetalloproteinase(MMP)-9andurokinase-typeplasminogenactivator(u-...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2006年第26卷第5期 -
CentralEuropeanDobravaHantavirusIsolatefromaStripedFieldMouse(Apodemusagrarius)
...virusgenus,familyBunyaviridae.J.Gen.Virol.76:2801-2808.Avsic-Zupanc,T.,S.Y.Xiao,R.Stojanovic,A.Gligic,G.vanderGroen,andJ.W.LeDuc.1992.CharacterizationofDobravavirus:ahantavirusfromSlovenia,Yugoslavia.J.Med.Virol.38:132-137.BrusSjolander,K.,I.Golovljova,V.Vasilenko,A.Plyusnin,andA.Lundkvist.2002.Sero...
医源资料库；在线期刊；微生物临床杂志；2005年第43卷第6期 -
Intensiveinsulintherapyprotectstheendotheliumofcriticallyillpatients
...lactivationisexcessive,compromisedmicrocirculationandsubsequentcellularhypoxiacontributetotheriskoforganfailure.Wehypothesizedthatstrictbloodglucosecontrolwithinsulinduringcriticalillnessprotectstheendothelium,mediatingpreventionoforganfailureanddeath.Inthispreplannedsubanalysisofalarge,randomizedco...
医源资料库；在线期刊；临床研究杂志；2005年第115卷第8期 -
PreservationofcomplexIfunctionduringhypoxia-reoxygenation-inducedmitochondrialinjuryinproximaltubules
...inasevereenergeticdeficitthatdevelopsinkidneyproximaltubulessubjectedtohypoxia-reoxygenationandisstronglyamelioratedbysupplementationwithspecificcitricacidcyclemetabolites,includingsuccinateandthecombinationof-ketoglutarateplusmalate.NADH:ubiquinonereductaseactivityinthetubuleswasdecreasedbyonly26%d...
医源资料库；在线期刊；美国生理学杂志；2004年第287卷第4期