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DysregulatedBoneMorphogeneticProteinSignalinginMonocrotaline-InducedPulmonaryArterialHypertension
...s.13-15TwoanimalmodelsofIPAHarecurrentlyinroutineuse:oneusingexposuretohypoxia,andtheotherusingthepyrrolizidinealkaloidmonocrotaline(MCT).16,17Inbothinstances,rightventricularhypertrophyandPAHdevelop.DespitewidespreaduseoftheMCTmodel,nostudytodatehasaddressedaroleforBMPsignalinginMCT-inducedPAH.Thed...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2007年第27卷第5期 -
ExpressionofAngiopoietin-2inEndothelialCellsIsControlledbyPositiveandNegativeRegulatoryPromoterElements
...dallowscytokinedependentpromoteractivation(Figures2and3).VEGF,FGF-2,andhypoxiahavebeenidentifiedaspotentinducersofAng-2expressioninendothelialcells.16Correspondingly,wedeterminedthattheactivityofpromoterfragmentslackingthepleiotropicnegativeregulatoryelementscanbeenhancedinresponsetoFGF-2,VEGF,andPM...
医源资料库；在线期刊；动脉硬化血栓血管生物学杂志；2004年第24卷第10期 -
HeparanSulfateRegulatestheAntiangiogenicActivityofEndothelialMonocyte-ActivatingPolypeptide-IIatAcidicpH
...othelialcellsthatisreleasedfromtumorcellsunderphysiologicalstresssuchashypoxia.WehavepreviouslyshownthattheinteractionbetweenEMAPIIandthe-subunitofATPsynthase,-ATPsynthase,canplayaregulatoryfunctioninthegrowthofendothelialcells.Inthecurrentstudy,wefoundthatEMAPII--ATPsynthaseinteractioncouldbeinhibi...
医源资料库；在线期刊；分子药理学杂志；2005年第67卷第5期 -
DualRoleforPlasminogenActivatorInhibitorTypeasSolubleandasMatricellularRegulatorofEpithelialAlveolarCellWoundHealing
...ialcellswasalsoreported,11manifestingasresistancetooxidativestressandhyperoxiaaswellastoirradiationorchemotherapy.12-14However,thisprotectionwasnotnecessarilyassociatedwithcellproliferationasinitiallysuggestedbyBarazzoneandcolleagues.15Indeed,duringepithelialalveolarwoundclosure,KGFwasshowntopromote...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第11期 -
Hypoxia-InducibleFactor-1(HIF-1)
【关键词】HIF-1Adaptationtolowoxygentension(hypoxia)incellsandtissuesleadstothetranscriptionalinductionofaseriesofgenesthatparticipateinangiogenesis,ironmetabolism,glucosemetabolism,andcellproliferation/survival.Theprimaryfactormediatingthisresponseisthehypoxia-induciblefactor-1(HIF-1),anoxygen...
医源资料库；在线期刊；分子药理学杂志；2006年第68卷第11期 -
Hypoxia-induciblefactormodulatestubularcellsurvivalincisplatinnephrotoxicity
...ricNephrology,MassachusettsGeneralHospital,Boston,MassachusettsABSTRACTHypoxia-induciblefactor(HIF)-1isatranscriptionfactormediatingcellularresponsetohypoxia.Althoughitisexpressedintubularcellsoftheischemickidney,itsfunctionalroleisnotfullyclarifiedinthepathologicalcontext.Inthisstudy,weinvestigated...
医源资料库；在线期刊；美国生理学杂志；2005年第288卷第11期 -
ElastinCalcificationintheRatSubdermalModelIsAccompaniedbyUp-RegulationofDegradativeandOsteogenicCellularResponses
...insterilesaline1to2hoursbeforeimplantation.FourratsweresacrificedbyCO2asphyxiationateachtimepoint(3,7,14,and21daysafterimplantation),andtheimplantswereretrievedalongwiththesurroundingfibrouscapsule.OneexplantfromeachratwasfrozeninOCT(SakuraFinetek,Zoeterwoude,TheNetherlands)ondryiceandstoredatC80??C...
医源资料库；在线期刊；美国病理学杂志；2006年第168卷第2期 -
InducibleNitricOxideSynthaseinLong-termIntermittentHypoxia
...dicine,Philadelphia,PennsylvaniaABSTRACTRationale:Long-termintermittenthypoxia(LTIH)exposureinadultmice,modelingoxygenationpatternsofmoderateeCsevereobstructivesleepapnea,resultsinlastinghypersomnolenceandisassociatedwithnitrationandoxidationinjuriesinmanybrainregions,includingwake-activeregions.Obj...
医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第6期 -
DoppelInducesDegenerationofCerebellarPurkinjeCellsIndependentlyofBax
...p-regulationofDpl,developasevereneurodegenerativedisordercharacterizedbyataxiaandlossofcerebellarPurkinjecells.Interestingly,thisphenotypeiscompletelysuppressedbythepresenceofthePrn-pgene.SubsequentstudiesofDpltransgenicmiceandPrn-d0/0miceconfirmedthatexpressionofDplintheCNSissufficienttoproduceneur...
医源资料库；在线期刊；美国病理学杂志；2007年第169卷第8期 -
NADPHOxidaseMediatesHypersomnolenceandBrainOxidativeInjuryinaMurineModelofSleepApnea
...apneamayhavesignificantresidualhypersomnolence,despitetherapy.Long-termhypoxia/reoxygenationeventsinadultmice,simulatingoxygenationpatternsofmoderateeCseveresleepapnea,resultinlastinghypersomnolence,oxidativeinjury,andproinflammatoryresponsesinwake-activebrainregions.Wehypothesizedthatlong-terminter...
医源资料库；在线期刊；美国呼吸和危急护理医学；2005年第171卷第10期