Multistabilityintubuloglomerularfeedbackandspectralcomplexityinspontaneouslyhypertensiverats
【摘要】Single-nephronproximaltubulepressureinspontaneouslyhypertensiverats(SHR)canexhibithighlyirregularoscillationssimilartodeterministicchaos.Weusedamathematicalmodeloftubuloglomerularfeedback(TGF)toinvestigatepotentialsourcesoftheirregularoscillationsandthecorrespondingcomplexpowerspectrainS...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第7期RepressionofArylHydrocarbonReceptor(AHR)SignalingbyAHRRepressor:RoleofDNABindingandCompetitionforAHRNuclearTranslocator
...ughsequestrationofARNT.AnAHRR1pointmutant(AHRR1-Y9F)thatcouldnotbindtoAHREsbutthatretaineditsnuclearlocalizationwasonlyslightlyreducedinitsabilitytorepressAHR2,demonstratingthatAHRRrepressiondoesnotoccursolelythroughcompetitionforAHREs.Whenbothproposedmechanismswereblocked(AHRR1-Y9FplusexcessARNT),A...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期Alix(AIP1)isavasopressinreceptor(V2R)-interactingproteinthatincreaseslysosomaldegradationoftheV2R
...nofligand(vasopressin)stimulationisanimportantphysiologicalregulatoryevent,butfewproteinsthatinteractwiththeV2Rduringdownregulationaftervasopressin(VP)bindinghavebeenidentified.Usingyeasttwo-hybridscreeningofahumankidneycDNAlibrary,weshowthata100-kDaproteincalledALG-2-interactingproteinX(Alix)intera...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期Ras-DependentRecruitmentofc-MycforTranscriptionalActivationofNucleophosmin/B23inHighlyMalignantU1BladderCancerCells
...ellscomparedwithU4cells.Moreover,c-Mycandnucleophosmin/B23wereincreasedinU1butnotinU4cellsuponserumstimulationfromquiescence.Likewise,onlyinU1cellscouldserumstimulatetranscriptionalactivityofnucleophosmin/B23promoterandc-Mycresponseelement.Theincreaseofnucleophosmin/B23promoteractivitycouldbeabrogat...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期GeneticDeterminantsofArterialThrombosis
...nUniversitySchoolofMedicine,715AlbanySt,W507,Boston,MA02118.E-mailjloscalz@bu.eduAbstractArterialthrombosisisacomplexdisorderthatinvolvesmultiplegeneticandenvironmentalfactorsinteractingtoproducethecharacteristicphenotype.Inthepastdecades,investigatorshavefocusedonthemoleculargeneticsofarterialvascu...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第2期JABDeterminestheResponseofRheumatoidArthritisSynovialFibroblaststoTumorNecrosisFactor-
...SN5)oftheCOP9signalosome(CSN)complex.TheCSNcomplex,whichiscomposedofeightsubunits(CSN1toCSN8),iswellconservedfromyeasttohuman,andisinvolvedinavarietyofbiologicalresponses.1,2JAB1isamultifunctionalproteinthatinteractswithnumerousmoleculesinvolvedinintracellularsignalingandcell-cyclecontrol,includingc...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期ThePhosphoinositide-DependentKinase-1Inhibitor2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide(OSU-03012)Prevents
...2001).Thisalludestotwochallenges:1)tofurtherunderstandthepathwaysthatcontributetotumorigenesisintheBLBCand2)tofindtargetedtherapiesforthosepathways.Theepidermalgrowthfactorreceptor(EGFR,orHer-1)isamolecularmarkerforBLBC,inwhichitishighlyexpressedinmorethanhalfofthetumorsinthissubtype(Nielsenetal.,20...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第9期SimultaneousActivationoftheOpioidReceptor(OR)/SensoryNeuron-SpecificReceptor-4(SNSR-4)Hetero-OligomerbytheMixedBivalentAgonistBovineAdrenal
...Hetero-oligomerizationamongGprotein-coupledreceptorshasbeenproposedtocontributetosignalintegration.Becausesensoryneuron-specificreceptors(SNSRs)andtheopioidreceptors(OR)shareacommonligand,thebovineadrenalmedullapeptide(BAM)22,andhaveoppositeeffectsonpainmodulation,weinvestigatedthepossibleconsequenc...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期Alzheimer??sDisease-LikeTauNeuropathologyLeadstoMemoryDeficitsandLossofFunctionalSynapsesinaNovelMutatedTauTransgenicMousewithoutAnyMoto
...nandbyamajorlossofsynapticconnections.NFTsareneuronalinclusionsofthemicrotubule-associatedtauproteinandarecomposedofaggregatedphosphorylatedtau.InAD,NFTsoccurinthehippocampus,theentorhinalandpolymodalassociationcortices,andinthebasalforebrain.Thesebrainareasarealsoseverelyaffectedbyneuronalandsynapt...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第8期RelaxinFamilyPeptideReceptorsRXFP1andRXFP2ModulatecAMPSignalingbyDistinctMechanisms
...dadelayedresponseinvolvingPI3KandPKC.ThisdelayedpathwaywasdependentuponG-subunitsderivedfromGi3.AnadditionalinhibitorypathwayinvolvingGoBaffectingcAMPaccumulationwasalsoidentified.InHEK293TcellsstablytransfectedwithRXFP2,thecAMPresponseinvolvedGsandwasmodulatedbyinhibitionmediatedbyGoBandreleaseofin...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期